positive regulation of cell population proliferation
immune system process
regulation of signaling receptor activity
cytokine-mediated signaling pathway
microglial cell proliferation
positive regulation of gene expression
positive regulation of oligodendrocyte differentiation
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
146433
76527
Ensembl
ENSG00000157368
ENSMUSG00000031750
UniProt
Q6ZMJ4
Q8R1R4
RefSeq (mRNA)
NM_001172771 NM_001172772 NM_152456
NM_001135100 NM_029646
RefSeq (protein)
NP_001166242 NP_001166243 NP_689669
NP_001128572 NP_083922
Location (UCSC)
Chr 16: 70.58 – 70.66 Mb
Chr 8: 111.47 – 111.53 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Interleukin 34 (IL-34) is a protein belonging to a group of cytokines called interleukins. It was originally identified in humans, by large scale screening of secreted proteins; chimpanzee, murine, rat and chicken interleukin 34 orthologs have also been found. The protein is composed of 241 amino acids, 39 kilodaltons in mass, and forms homodimers. IL-34 increases growth or survival of immune cells known as monocytes; it elicits its activity by binding the Colony stimulating factor 1 receptor.
Messenger RNA (mRNA) expression of human IL-34 is most abundant in spleen but occurs in several other tissues: thymus, liver, small intestine, colon, prostate gland, lung, heart, brain, kidney, testes, and ovary. The discovery of IL-34 protein in the red pulp of the spleen suggests involvement in growth and development of myeloid cells, consistent with its activity on monocytes.
[5]
^ abcGRCh38: Ensembl release 89: ENSG00000157368 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000031750 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Lin H, Lee E, Hestir K, et al. (May 2008). "Discovery of a cytokine and its receptor by functional screening of the extracellular proteome". Science. 320 (5877): 807–11. Bibcode:2008Sci...320..807L. doi:10.1126/science.1154370. PMID 18467591. S2CID 44340470.
Interleukin34 (IL-34) is a protein belonging to a group of cytokines called interleukins. It was originally identified in humans, by large scale screening...
Interleukins (ILs) are a group of cytokines (secreted proteins and signal molecules) that are expressed and secreted by white blood cells (leukocytes)...
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immunomodulating agents. Cytokines include chemokines, interferons, interleukins, lymphokines, and tumour necrosis factors, but generally not hormones...
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