Interferon-alpha/beta receptor, fibronectin type III
Identifiers
Symbol
Interfer-bind
Pfam
Interfer-bind
InterPro
IPR015373
SCOP2
1n6u / SCOPe / SUPFAM
Available protein structures:
Pfam
structures / ECOD
PDB
RCSB PDB; PDBe; PDBj
PDBsum
structure summary
Type II cytokine receptors, also commonly known as class II cytokine receptors, are transmembrane proteins that are expressed on the surface of certain cells. They bind and respond to a select group of cytokines including interferon type I, interferon type II, interferon type III.[1] and members of the interleukin-10 family[2][3] These receptors are characterized by the lack of a WSXWS motif which differentiates them from type I cytokine receptors.[4]
^Krey K, Babnis AW, Pichlmair A (October 2020). "System-Based Approaches to Delineate the Antiviral Innate Immune Landscape". Viruses. 12 (10): 1196. doi:10.3390/v12101196. PMC 7589202. PMID 33096788.
^Cite error: The named reference pmid11481447 was invoked but never defined (see the help page).
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^Stanifer ML, Pervolaraki K, Boulant S (March 2019). "Differential Regulation of Type I and Type III Interferon Signaling". International Journal of Molecular Sciences. 20 (6): 1445. doi:10.3390/ijms20061445. PMC 6471306. PMID 30901970.
and 15 Related for: Type II cytokine receptor information
Cytokinereceptors are receptors that bind to cytokines. In recent years, the cytokinereceptors have come to demand the attention of more investigators...
Type I cytokinereceptors are transmembrane receptors expressed on the surface of cells that recognize and respond to cytokines with four α-helical strands...
non-receptor tyrosine kinase. It is a member of the Janus kinase family and has been implicated in signaling by members of the typeIIcytokinereceptor family...
various stromal cells; a given cytokine may be produced by more than one type of cell. They act through cell surface receptors and are especially important...
functionality. Toll-like receptors were first discovered in Drosophila and trigger the synthesis and secretion of cytokines and activation of other host...
Janus kinase (JAK) is a family of intracellular, non-receptor tyrosine kinases that transduce cytokine-mediated signals via the JAK-STAT pathway. They were...
An inflammatory cytokine or proinflammatory cytokine is a type of signaling molecule (a cytokine) that is secreted from immune cells like helper T cells...
Interferon gamma (IFNG or IFN-γ) is a dimerized soluble cytokine that is the only member of the typeII class of interferons. The existence of this interferon...
Receptor tyrosine kinases (RTKs) are the high-affinity cell surface receptors for many polypeptide growth factors, cytokines, and hormones. Of the 90 unique...
certain type I and typeIIcytokines. It interacts with the common gamma chain (γc) of type I cytokinereceptors, to elicit signals from the IL-2 receptor family...
The type-I interferons (IFN) are cytokines which play essential roles in inflammation, immunoregulation, tumor cells recognition, and T-cell responses...
release cytokines to aid other immune cells. Cytokines are small protein mediators that alter the behavior of target cells that express receptors for those...
member of the class of tall cytokinereceptors. It forms one subunit of the type I cytokinereceptor within the IL-6 receptor family. It is often referred...
Global Information