negative regulation of endothelial cell apoptotic process
negative regulation of complement-dependent cytotoxicity
regulation of phosphorylation
negative regulation of apoptotic process
myeloid dendritic cell differentiation
type 2 immune response
B cell activation
positive regulation of interleukin-13 production
immune response
B cell differentiation
T-helper 2 cell cytokine production
regulation of isotype switching
negative regulation of transcription, DNA-templated
negative regulation of epithelial cell migration
regulation of signaling receptor activity
cholesterol metabolic process
positive regulation of B cell proliferation
positive regulation of T cell proliferation
T cell activation
positive regulation of MHC class II biosynthetic process
negative regulation of osteoclast differentiation
positive regulation of transcription, DNA-templated
positive regulation of transcription by RNA polymerase II
positive regulation of isotype switching to IgE isotypes
positive regulation of isotype switching to IgG isotypes
regulation of immune response
cytokine-mediated signaling pathway
positive regulation of gene expression
positive regulation of macroautophagy
positive regulation of tyrosine phosphorylation of STAT protein
activation of Janus kinase activity
positive regulation of receptor-mediated endocytosis
positive regulation of cold-induced thermogenesis
negative regulation of neuroinflammatory response
positive regulation of amyloid-beta clearance
neuroinflammatory response
positive regulation of cellular respiration
positive regulation of ATP biosynthetic process
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
3565
16189
Ensembl
ENSG00000113520
ENSMUSG00000000869
UniProt
P05112
P07750
RefSeq (mRNA)
NM_000589.4
NM_021283
RefSeq (protein)
NP_000580 NP_758858 NP_001341919
NP_067258
Location (UCSC)
Chr 5: 132.01 – 132.02 Mb
Chr 11: 53.49 – 53.51 Mb
PubMed search
[2]
[3]
Wikidata
View/Edit Human
View/Edit Mouse
Interleukin 4
analysis of the solution structure of human interleukin 4 determined by heteronuclear three-dimensional nuclear magnetic resonance techniques
Identifiers
Symbol
IL4
Pfam
PF00727
Pfam clan
CL0053
InterPro
IPR002354
PROSITE
PDOC00655
SCOP2
2int / SCOPe / SUPFAM
Available protein structures:
Pfam
structures / ECOD
PDB
RCSB PDB; PDBe; PDBj
PDBsum
structure summary
The interleukin 4 (IL4, IL-4) is a cytokine that induces differentiation of naive helper T cells (Th0 cells) to Th2 cells. Upon activation by IL-4, Th2 cells subsequently produce additional IL-4 in a positive feedback loop. IL-4 is produced primarily by mast cells, Th2 cells, eosinophils and basophils.[4] It is closely related and has functions similar to IL-13.
^ abcGRCm38: Ensembl release 89: ENSMUSG00000000869 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Gadani SP, Cronk JC, Norris GT, Kipnis J (November 2012). "IL-4 in the brain: a cytokine to remember". Journal of Immunology. 189 (9): 4213–4219. doi:10.4049/jimmunol.1202246. PMC 3481177. PMID 23087426.
The interleukin4 (IL4, IL-4) is a cytokine that induces differentiation of naive helper T cells (Th0 cells) to Th2 cells. Upon activation by IL-4, Th2 cells...
Interleukins (ILs) are a group of cytokines (secreted proteins and signal molecules) that are expressed and secreted by white blood cells (leukocytes)...
Interleukin 6 (IL-6) is an interleukin that acts as both a pro-inflammatory cytokine and an anti-inflammatory myokine. In humans, it is encoded by the...
Interleukin 12 (IL-12) is an interleukin that is naturally produced by dendritic cells, macrophages, neutrophils, helper T cells and human B-lymphoblastoid...
Interleukin-2 (IL-2) is an interleukin, a type of cytokine signaling molecule in the immune system. It is a 15.5–16 kDa protein that regulates the activities...
Interleukin 13 (IL-13) is a protein that in humans is encoded by the IL13 gene. IL-13 was first cloned in 1993 and is located on chromosome 5q31.1 with...
Interleukin 23 (IL-23) is a heterodimeric cytokine composed of an IL-12B (IL-12p40) subunit (which is shared with IL-12) and an IL-23A (IL-23p19) subunit...
Interleukin 8 (IL-8 or chemokine (C-X-C motif) ligand 8, CXCL8) is a chemokine produced by macrophages and other cell types such as epithelial cells,...
Interleukin 5 (IL-5) is an interleukin produced by type-2 T helper cells and mast cells. Through binding to the interleukin-5 receptor, interleukin 5...
Interleukin 33 (IL-33) is a protein that in humans is encoded by the IL33 gene. Interleukin 33 is a member of the IL-1 family that potently drives production...
Interleukin 10 (IL-10), also known as human cytokine synthesis inhibitory factor (CSIF), is an anti-inflammatory cytokine. In humans, interleukin 10 is...
Interleukin 7 (IL-7) is a protein that in humans is encoded by the IL7 gene. IL-7 is a hematopoietic growth factor secreted by stromal cells in the bone...
Interleukin 3 (IL-3) is a protein that in humans is encoded by the IL3 gene localized on chromosome 5q31.1. Sometimes also called colony-stimulating factor...
Interleukin 17 family (IL17 family) is a family of pro-inflammatory cystine knot cytokines. They are produced by a group of T helper cell known as T helper...
the brand name Dupixent, is a monoclonal antibody blocking interleukin4 and interleukin 13, used for allergic diseases such as atopic dermatitis (eczema)...
Interleukin-18 (IL-18), also known as interferon-gamma inducing factor is a protein which in humans is encoded by the IL18 gene. The protein encoded by...
two subunits of the cytokine Interleukin-23. Interleukin-23 (IL-23) is a heterodimeric cytokine composed of an Interleukin 23 alpha subunit and an IL-12p40...
The Interleukin-2 receptor alpha chain (also called TAC antigen, P55, and mainly CD25) is a protein involved in the assembly of the high-affinity Interleukin-2...
receptor complexes for at least six different interleukin receptors: IL-2, IL-4, IL-7, IL-9, IL-15 and interleukin-21 receptor. The γc glycoprotein is a member...
ISBN 978-0-443-07145-4. Page 223 Saraiva M, Christensen JR, Veldhoen M, Murphy TL, Murphy KM, O'Garra A (August 2009). "Interleukin-10 production by Th1...
Interleukin-22 (IL-22) is protein that in humans is encoded by the IL22 gene. IL-22 is an α-helical cytokine. IL-22 binds to a heterodimeric cell surface...
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