positive regulation of peptidyl-serine phosphorylation
positive regulation of leukocyte chemotaxis
positive regulation of T cell proliferation
positive regulation of interleukin-6 production
positive regulation of peptidyl-tyrosine phosphorylation
positive regulation of acute inflammatory response
inflammatory response
negative regulation of collagen biosynthetic process
positive regulation of MAPK cascade
hepatic immune response
monocyte chemotaxis
positive regulation of DNA-binding transcription factor activity
negative regulation of apoptotic process
positive regulation of osteoblast differentiation
positive regulation of NF-kappaB transcription factor activity
acute-phase response
immune response
regulation of vascular endothelial growth factor production
positive regulation of chemokine production
negative regulation of lipid storage
neutrophil mediated immunity
positive regulation of smooth muscle cell proliferation
positive regulation of type B pancreatic cell apoptotic process
response to glucocorticoid
defense response to Gram-negative bacterium
positive regulation of cell population proliferation
positive regulation of apoptotic process
positive regulation of B cell activation
post-translational protein modification
regulation of signaling receptor activity
positive regulation of tyrosine phosphorylation of STAT protein
neutrophil apoptotic process
negative regulation of cell population proliferation
positive regulation of gene expression
endocrine pancreas development
negative regulation of bone resorption
positive regulation of transcription, DNA-templated
positive regulation of transcription by RNA polymerase II
glucagon secretion
cellular response to hydrogen peroxide
cellular response to lipopolysaccharide
T-helper 17 cell lineage commitment
positive regulation of T-helper 2 cell cytokine production
negative regulation of interleukin-1-mediated signaling pathway
cytokine-mediated signaling pathway
interleukin-6-mediated signaling pathway
positive regulation of receptor signaling pathway via JAK-STAT
signal transduction
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
3569
16193
Ensembl
ENSG00000136244
ENSMUSG00000025746
UniProt
P05231
P08505
RefSeq (mRNA)
NM_000600 NM_001318095 NM_001371096
NM_031168 NM_001314054
RefSeq (protein)
NP_000591 NP_001305024 NP_001358025
NP_001300983 NP_112445
Location (UCSC)
Chr 7: 22.73 – 22.73 Mb
Chr 5: 30.22 – 30.22 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Interleukin 6 (IL-6) is an interleukin that acts as both a pro-inflammatory cytokine and an anti-inflammatory myokine. In humans, it is encoded by the IL6 gene.[5]
In addition, osteoblasts secrete IL-6 to stimulate osteoclast formation. Smooth muscle cells in the tunica media of many blood vessels also produce IL-6 as a pro-inflammatory cytokine. IL-6's role as an anti-inflammatory myokine is mediated through its inhibitory effects on TNF-alpha and IL-1 and its activation of IL-1ra and IL-10.
There is some early evidence that IL-6 can be used as an inflammatory marker for severe COVID-19 infection with poor prognosis, in the context of the wider coronavirus pandemic.[6]
^ abcGRCh38: Ensembl release 89: ENSG00000136244 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000025746 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Ferguson-Smith AC, Chen YF, Newman MS, May LT, Sehgal PB, Ruddle FH (April 1988). "Regional localization of the interferon-beta 2/B-cell stimulatory factor 2/hepatocyte stimulating factor gene to human chromosome 7p15-p21". Genomics. 2 (3): 203–208. doi:10.1016/0888-7543(88)90003-1. PMID 3294161.
^"Raised troponin and interleukin-6 levels are associated with a poor prognosis in COVID-19". Cardiac Rhythm News. 2 April 2020.
Interleukin6 (IL-6) is an interleukin that acts as both a pro-inflammatory cytokine and an anti-inflammatory myokine. In humans, it is encoded by the...
Interleukins (ILs) are a group of cytokines (secreted proteins and signal molecules) that are expressed and secreted by white blood cells (leukocytes)...
Interleukin 10 (IL-10), also known as human cytokine synthesis inhibitory factor (CSIF), is an anti-inflammatory cytokine. In humans, interleukin 10 is...
8511589. PMID 8511589. Kishimoto T, Akira S, Narazaki M, Taga T (1995). "Interleukin-6 family of cytokines and gp130". Blood. 86 (4): 1243–1254. doi:10.1182/blood...
Interleukin 5 (IL-5) is an interleukin produced by type-2 T helper cells and mast cells. Through binding to the interleukin-5 receptor, interleukin 5...
Interleukin 8 (IL-8 or chemokine (C-X-C motif) ligand 8, CXCL8) is a chemokine produced by macrophages and other cell types such as epithelial cells,...
The interleukin 4 (IL4, IL-4) is a cytokine that induces differentiation of naive helper T cells (Th0 cells) to Th2 cells. Upon activation by IL-4, Th2 cells...
myokine, myostatin, was identified. The gp130 receptor cytokine IL-6 (Interleukin6) was the first myokine found to be secreted into the blood stream in...
Rösel, Daniel; Dvořánková, Barbora; Smetana, Karel (26 October 2020). "Interleukin-6: Molecule in the Intersection of Cancer, Ageing and COVID-19". International...
Interleukin-18 (IL-18), also known as interferon-gamma inducing factor is a protein which in humans is encoded by the IL18 gene. The protein encoded by...
Interleukin-2 (IL-2) is an interleukin, a type of cytokine signaling molecule in the immune system. It is a 15.5–16 kDa protein that regulates the activities...
Interleukin 12 (IL-12) is an interleukin that is naturally produced by dendritic cells, macrophages, neutrophils, helper T cells and human B-lymphoblastoid...
Interleukin 17 family (IL17 family) is a family of pro-inflammatory cystine knot cytokines. They are produced by a group of T helper cell known as T helper...
Interleukin 23 (IL-23) is a heterodimeric cytokine composed of an IL-12B (IL-12p40) subunit (which is shared with IL-12) and an IL-23A (IL-23p19) subunit...
reduce glial scarring. Interleukins are another potential family of scar-inducing cellular messengers. Particularly, interleukin-1, a protein produced...
Interleukin 13 (IL-13) is a protein that in humans is encoded by the IL13 gene. IL-13 was first cloned in 1993 and is located on chromosome 5q31.1 with...
of myxoma may be associated with the release of interleukin6 (IL-6) by the myxoma. High levels of IL-6 may be associated with a higher risk of embolism...
It is a humanized monoclonal antibody against the interleukin-6 receptor (IL-6R). Interleukin6 (IL-6) is a cytokine that plays an important role in immune...
Interleukin 7 (IL-7) is a protein that in humans is encoded by the IL7 gene. IL-7 is a hematopoietic growth factor secreted by stromal cells in the bone...
Interleukin 3 (IL-3) is a protein that in humans is encoded by the IL3 gene localized on chromosome 5q31.1. Sometimes also called colony-stimulating factor...
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