cellular response to fibroblast growth factor stimulus
response to endoplasmic reticulum stress
positive regulation of angiogenesis
regulation of single stranded viral RNA replication via double stranded DNA intermediate
PERK-mediated unfolded protein response
induction of positive chemotaxis
chemotaxis
regulation of cell adhesion
immune response
cellular response to interleukin-1
angiogenesis
positive regulation of neutrophil chemotaxis
inflammatory response
negative regulation of G protein-coupled receptor signaling pathway
response to molecule of bacterial origin
cellular response to lipopolysaccharide
embryonic digestive tract development
signal transduction
negative regulation of cell population proliferation
calcium-mediated signaling
regulation of entry of bacterium into host cell
defense response
neutrophil chemotaxis
neutrophil activation
antimicrobial humoral immune response mediated by antimicrobial peptide
regulation of signaling receptor activity
cytokine-mediated signaling pathway
leukocyte chemotaxis
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
3576
n/a
Ensembl
ENSG00000169429
n/a
UniProt
P10145
n/a
RefSeq (mRNA)
NM_000584 NM_001354840
n/a
RefSeq (protein)
NP_000575 NP_001341769
n/a
Location (UCSC)
Chr 4: 73.74 – 73.74 Mb
n/a
PubMed search
[2]
n/a
Wikidata
View/Edit Human
Interleukin 8 (IL-8 or chemokine (C-X-C motif) ligand 8, CXCL8) is a chemokine produced by macrophages and other cell types such as epithelial cells, airway smooth muscle cells[3] and endothelial cells. Endothelial cells store IL-8 in their storage vesicles, the Weibel-Palade bodies.[4][5] In humans, the interleukin-8 protein is encoded by the CXCL8 gene.[6] IL-8 is initially produced as a precursor peptide of 99 amino acids which then undergoes cleavage to create several active IL-8 isoforms.[7] In culture, a 72 amino acid peptide is the major form secreted by macrophages.[7]
There are many receptors on the surface membrane capable of binding IL-8; the most frequently studied types are the G protein-coupled serpentine receptors CXCR1 and CXCR2. Expression and affinity for IL-8 differs between the two receptors (CXCR1 > CXCR2). Through a chain of biochemical reactions, IL-8 is secreted and is an important mediator of the immune reaction in the innate immune system response.
^ abcGRCh38: Ensembl release 89: ENSG00000169429 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Hedges JC, Singer CA, Gerthoffer WT (2000). "Mitogen-activated protein kinases regulate cytokine gene expression in human airway myocytes". Am. J. Respir. Cell Mol. Biol. 23 (1): 86–94. CiteSeerX 10.1.1.326.6212. doi:10.1165/ajrcmb.23.1.4014. PMID 10873157.
^Wolff B, Burns AR, Middleton J, Rot A (1998). "Endothelial cell "memory" of inflammatory stimulation: human venular endothelial cells store interleukin 8 in Weibel-Palade bodies". J. Exp. Med. 188 (9): 1757–62. doi:10.1084/jem.188.9.1757. PMC 2212526. PMID 9802987.
^Utgaard JO, Jahnsen FL, Bakka A, Brandtzaeg P, Haraldsen G (1998). "Rapid secretion of prestored interleukin 8 from Weibel-Palade bodies of microvascular endothelial cells". J. Exp. Med. 188 (9): 1751–6. doi:10.1084/jem.188.9.1751. PMC 2212514. PMID 9802986.
^Modi WS, Dean M, Seuanez HN, Mukaida N, Matsushima K, O'Brien SJ (1990). "Monocyte-derived neutrophil chemotactic factor (MDNCF/IL-8) resides in a gene cluster along with several other members of the platelet factor 4 gene superfamily". Hum. Genet. 84 (2): 185–7. doi:10.1007/BF00208938. PMID 1967588. S2CID 2217894.
^ abBrat DJ, Bellail AC, Van Meir EG (2005). "The role of interleukin-8 and its receptors in gliomagenesis and tumoral angiogenesis". Neuro-Oncology. 7 (2): 122–133. doi:10.1215/s1152851704001061. PMC 1871893. PMID 15831231.
Interleukin8 (IL-8 or chemokine (C-X-C motif) ligand 8, CXCL8) is a chemokine produced by macrophages and other cell types such as epithelial cells,...
Interleukins (ILs) are a group of cytokines (secreted proteins and signal molecules) that are expressed and secreted by white blood cells (leukocytes)...
Interleukin 6 (IL-6) is an interleukin that acts as both a pro-inflammatory cytokine and an anti-inflammatory myokine. In humans, it is encoded by the...
then through interstitial space, following chemical signals such as interleukin-8 (IL-8), C5a, fMLP, leukotriene B4, and hydrogen peroxide (H2O2) in a process...
Interleukin 10 (IL-10), also known as human cytokine synthesis inhibitory factor (CSIF), is an anti-inflammatory cytokine. In humans, interleukin 10 is...
CXCR1 and CXCR2. An example of an ELR-positive CXC chemokine is interleukin-8 (IL-8), which induces neutrophils to leave the bloodstream and enter into...
Interleukin 7 (IL-7) is a protein that in humans is encoded by the IL7 gene. IL-7 is a hematopoietic growth factor secreted by stromal cells in the bone...
CD14(+) fibroblasts primed with gamma interferon increase production of interleukin-8 in response to lipopolysaccharide through up-regulation of membrane...
Interleukin-2 (IL-2) is an interleukin, a type of cytokine signaling molecule in the immune system. It is a 15.5–16 kDa protein that regulates the activities...
Interleukin 12 (IL-12) is an interleukin that is naturally produced by dendritic cells, macrophages, neutrophils, helper T cells and human B-lymphoblastoid...
which ultimately results in the down-regulation of pro-inflammatory interleukin-8 production. Niacinamide at doses of 500 to 1000 mg a day decreases the...
PTK7, Complement Receptor 1 and 2 (CR1, CR2) and the production of interleukin8 (IL-8). Like all T cells, they express the T cell receptor-CD3 complex...
Interleukin 5 (IL-5) is an interleukin produced by type-2 T helper cells and mast cells. Through binding to the interleukin-5 receptor, interleukin 5...
The interleukin 4 (IL4, IL-4) is a cytokine that induces differentiation of naive helper T cells (Th0 cells) to Th2 cells. Upon activation by IL-4, Th2 cells...
expansion process include Interleukin 1α (IL1A), Interleukin 6, and Interleukin8, while the anti-inflammatory mediator is Interleukin 10. Mediators that promote...
S, et al. (February 2021). "Azithromycin and ciprofloxacin inhibit interleukin-8 secretion without disrupting human sinonasal epithelial integrity in...
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