positive regulation of T cell mediated cytotoxicity
positive regulation of interferon-gamma production
positive regulation of natural killer cell activation
positive regulation of osteoclast differentiation
positive regulation of T-helper 17 cell lineage commitment
positive regulation of NK T cell activation
T cell proliferation
positive regulation of natural killer cell proliferation
positive regulation of NK T cell proliferation
positive regulation of T-helper 17 type immune response
defense response to virus
positive regulation of tissue remodeling
positive regulation of T-helper 1 type immune response
positive regulation of granulocyte macrophage colony-stimulating factor production
defense response to Gram-negative bacterium
positive regulation of T cell proliferation
immune response
positive regulation of memory T cell differentiation
positive regulation of neutrophil chemotaxis
positive regulation of tumor necrosis factor production
positive regulation of interleukin-17 production
innate immune response
inflammatory response
tissue remodeling
positive regulation of transcription by RNA polymerase II
positive regulation of activated T cell proliferation
positive regulation of defense response to virus by host
positive regulation of activation of Janus kinase activity
regulation of tyrosine phosphorylation of STAT protein
positive regulation of tyrosine phosphorylation of STAT protein
regulation of signaling receptor activity
cytokine-mediated signaling pathway
interleukin-23-mediated signaling pathway
positive regulation of NIK/NF-kappaB signaling
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
51561
83430
Ensembl
ENSG00000110944
ENSMUSG00000025383
UniProt
Q9NPF7
Q9EQ14
RefSeq (mRNA)
NM_016584
NM_031252
RefSeq (protein)
NP_057668
NP_112542
Location (UCSC)
Chr 12: 56.33 – 56.34 Mb
Chr 10: 128.13 – 128.13 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Interleukin-23 subunit alpha is a protein that in humans is encoded by the IL23A gene.[5][6] The protein is also known as IL-23p19. It is one of the two subunits of the cytokine Interleukin-23.
Interleukin-23 (IL-23) is a heterodimeric cytokine composed of an Interleukin 23 alpha subunit and an IL-12p40 subunit. The IL-12p40, also known as Interleukin 12 subunit beta, is used by both IL-23 (where it partners with IL-23p19) and IL-12 (where it partners with IL-12A).[5] A functional receptor for IL-23 (the IL-23 receptor) has been identified and is composed of IL-12R β1 and IL-23R.[7]
^ abcGRCh38: Ensembl release 89: ENSG00000110944 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000025383 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ abOppmann B, Lesley R, Blom B, Timans JC, Xu Y, Hunte B, et al. (November 2000). "Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12". Immunity. 13 (5): 715–25. doi:10.1016/S1074-7613(00)00070-4. PMID 11114383.
^Parham C, Chirica M, Timans J, Vaisberg E, Travis M, Cheung J, et al. (June 2002). "A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R". Journal of Immunology. 168 (11): 5699–708. doi:10.4049/jimmunol.168.11.5699. PMID 12023369.
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Global Information
