negative regulation of chronic inflammatory response to antigenic stimulus
positive regulation of MHC class II biosynthetic process
negative regulation of endothelial cell apoptotic process
hemopoiesis
negative regulation of interferon-gamma production
regulation of sensory perception of pain
positive regulation of B cell apoptotic process
negative regulation of chemokine (C-C motif) ligand 5 production
response to inactivity
negative regulation of cytokine activity
negative regulation of interleukin-1 production
cellular response to hepatocyte growth factor stimulus
cellular response to estradiol stimulus
negative regulation of interleukin-6 production
human ageing
positive regulation of DNA-binding transcription factor activity
negative regulation of apoptotic process
negative regulation of cytokine production involved in immune response
response to glucocorticoid
cytoplasmic sequestering of NF-kappaB
negative regulation of interleukin-18 production
negative regulation of MHC class II biosynthetic process
response to activity
response to organic substance
response to carbon monoxide
leukocyte chemotaxis
type 2 immune response
negative regulation of myeloid dendritic cell activation
response to insulin
negative regulation of interleukin-8 production
response to lipopolysaccharide
B cell proliferation
negative regulation of T cell proliferation
negative regulation of nitric oxide biosynthetic process
branching involved in labyrinthine layer morphogenesis
defense response to bacterium
regulation of complement-dependent cytotoxicity
immune response
regulation of gene expression
B cell differentiation
regulation of isotype switching
negative regulation of tumor necrosis factor production
negative regulation of membrane protein ectodomain proteolysis
inflammatory response
cellular response to lipopolysaccharide
negative regulation of B cell proliferation
negative regulation of inflammatory response
negative regulation of cytokine production
positive regulation of transcription by RNA polymerase II
negative regulation of interleukin-12 production
defense response to protozoan
negative regulation of sensory perception of pain
positive regulation of macrophage activation
liver regeneration
regulation of synapse organization
positive regulation of endothelial cell proliferation
negative regulation of cell population proliferation
negative regulation of heterotypic cell-cell adhesion
positive regulation of heterotypic cell-cell adhesion
positive regulation of cell cycle
negative regulation of mitotic cell cycle
endothelial cell apoptotic process
regulation of response to wounding
negative regulation of vascular associated smooth muscle cell proliferation
positive regulation of vascular associated smooth muscle cell proliferation
interleukin-12-mediated signaling pathway
positive regulation of transcription, DNA-templated
negative regulation of autophagy
cytokine-mediated signaling pathway
positive regulation of receptor signaling pathway via JAK-STAT
positive regulation of pri-miRNA transcription by RNA polymerase II
negative regulation of hydrogen peroxide-induced neuron death
positive regulation of sprouting angiogenesis
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
3586
16153
Ensembl
ENSG00000136634
ENSMUSG00000016529
UniProt
P22301
P18893
RefSeq (mRNA)
NM_000572
NM_010548
RefSeq (protein)
NP_000563
NP_034678
Location (UCSC)
Chr 1: 206.77 – 206.77 Mb
Chr 1: 130.95 – 130.95 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Interleukin 10 (IL-10), also known as human cytokine synthesis inhibitory factor (CSIF), is an anti-inflammatory cytokine. In humans, interleukin 10 is encoded by the IL10 gene.[5] IL-10 signals through a receptor complex consisting of two IL-10 receptor-1 and two IL-10 receptor-2 proteins.[6] Consequently, the functional receptor consists of four IL-10 receptor molecules. IL-10 binding induces STAT3 signalling via the phosphorylation of the cytoplasmic tails of IL-10 receptor 1 + IL-10 receptor 2 by JAK1 and Tyk2 respectively.[6]
^ abcGRCh38: Ensembl release 89: ENSG00000136634 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000016529 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Eskdale J, Kube D, Tesch H, Gallagher G (1997). "Mapping of the human IL10 gene and further characterization of the 5' flanking sequence". Immunogenetics. 46 (2): 120–8. doi:10.1007/s002510050250. PMID 9162098. S2CID 30126106.
^ abMosser DM, Zhang X (December 2008). "Interleukin-10: new perspectives on an old cytokine". Immunological Reviews. 226 (1): 205–18. doi:10.1111/j.1600-065X.2008.00706.x. PMC 2724982. PMID 19161426.
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