This article is about the protein family. For its founding member, see IL17A.
Interleukin 17 family
Identifiers
Symbol
IL-17_fam
Pfam
PF06083
InterPro
IPR010345
Available protein structures:
Pfam
structures / ECOD
PDB
RCSB PDB; PDBe; PDBj
PDBsum
structure summary
Interleukin 17A
Identifiers
Symbol
IL17A
Alt. symbols
IL17, CTLA8
NCBI gene
3605
HGNC
5981
OMIM
603149
RefSeq
NP_002181
UniProt
Q16552
Other data
Locus
Chr. 6 p12
Search for
Structures
Swiss-model
Domains
InterPro
Interleukin 17B
Identifiers
Symbol
IL17B
Alt. symbols
ZCOTO7
NCBI gene
27190
HGNC
5982
OMIM
604627
RefSeq
NP_055258
UniProt
Q9UHF5
Other data
Locus
Chr. 5 q32-34
Search for
Structures
Swiss-model
Domains
InterPro
Interleukin 17C
Identifiers
Symbol
IL17C
Alt. symbols
CX2
NCBI gene
27189
HGNC
5983
OMIM
604628
RefSeq
NP_037410
UniProt
Q9P0M4
Other data
Locus
Chr. 16 q24
Search for
Structures
Swiss-model
Domains
InterPro
Interleukin 17D
Identifiers
Symbol
IL17D
NCBI gene
53342
HGNC
5984
OMIM
607587
RefSeq
NP_612141
UniProt
Q8TAD2
Other data
Locus
Chr. 13 q11
Search for
Structures
Swiss-model
Domains
InterPro
Interleukin 17E
Identifiers
Symbol
IL17E
Alt. symbols
IL-25
NCBI gene
64806
HGNC
13765
OMIM
605658
RefSeq
NP_073626
UniProt
Q9H293
Other data
Locus
Chr. 14 q11.2
Search for
Structures
Swiss-model
Domains
InterPro
Interleukin 17F
Crystallographic structure of dimeric human IL-17f.[1]
Identifiers
Symbol
IL17F
Alt. symbols
ML-1
NCBI gene
112744
HGNC
16404
OMIM
606496
PDB
1JPY
RefSeq
NP_443104
UniProt
Q96PD4
Other data
Locus
Chr. 6 p12
Search for
Structures
Swiss-model
Domains
InterPro
Interleukin 17 family (IL17 family) is a family of pro-inflammatory cystine knot cytokines.[2] They are produced by a group of T helper cell known as T helper 17 cell in response to their stimulation with IL-23. Originally, Th17 was identified in 1993 by Rouvier et al. who isolated IL17A transcript from a rodent T-cell hybridoma.[3] The protein encoded by IL17A is a founding member of IL-17 family (see below). IL17A protein exhibits a high homology with a viral IL-17-like protein (O40633) encoded in the genome of T-lymphotropic rhadinovirus Herpesvirus saimiri. In rodents, IL-17A is often referred to as CTLA8.[4]
The biologically active IL-17 interacts with type I cell surface receptor IL-17R. In turn, there are at least three variants of IL-17R referred to as IL17RA, IL17RB, and IL17RC.[5] After binding to the receptor, IL-17 activates several signalling cascades that, in turn, lead to the induction of chemokines. Acting as chemoattractants, these chemokines recruit the immune cells, such as monocytes and neutrophils to the site of inflammation. Typically, the signaling events mentioned above follow an invasion of the body by pathogens. Promoting the inflammation, IL-17 acts in concert with tumor necrosis factor and interleukin-1.[6][7] Moreover, an activation of IL-17 signalling is often observed in the pathogenesis of various autoimmune disorders, such as psoriasis.[8]
^PDB: 1JPY; Hymowitz SG, Filvaroff EH, Yin JP, Lee J, Cai L, Risser P, et al. (October 2001). "IL-17s adopt a cystine knot fold: structure and activity of a novel cytokine, IL-17F, and implications for receptor binding". The EMBO Journal. 20 (19): 5332–41. doi:10.1093/emboj/20.19.5332. PMC 125646. PMID 11574464.
^Moseley TA, Haudenschild DR, Rose L, Reddi AH (April 2003). "Interleukin-17 family and IL-17 receptors". Cytokine & Growth Factor Reviews. 14 (2): 155–74. doi:10.1016/S1359-6101(03)00002-9. PMID 12651226.
^Johansen C, Usher PA, Kjellerup RB, Lundsgaard D, Iversen L, Kragballe K (February 2009). "Characterization of the interleukin-17 isoforms and receptors in lesional psoriatic skin". The British Journal of Dermatology. 160 (2): 319–24. doi:10.1111/j.1365-2133.2008.08902.x. PMID 19016708. S2CID 205257996.
^Rouvier E, Luciani MF, Mattéi MG, Denizot F, Golstein P (June 1993). "CTLA-8, cloned from an activated T cell, bearing AU-rich messenger RNA instability sequences, and homologous to a herpesvirus saimiri gene". Journal of Immunology. 150 (12): 5445–56. doi:10.4049/jimmunol.150.12.5445. PMID 8390535.
^Starnes T, Broxmeyer HE, Robertson MJ, Hromas R (July 2002). "Cutting edge: IL-17D, a novel member of the IL-17 family, stimulates cytokine production and inhibits hemopoiesis". Journal of Immunology. 169 (2): 642–6. doi:10.4049/jimmunol.169.2.642. PMID 12097364.
^Chiricozzi A, Guttman-Yassky E, Suárez-Fariñas M, Nograles KE, Tian S, Cardinale I, et al. (March 2011). "Integrative responses to IL-17 and TNF-α in human keratinocytes account for key inflammatory pathogenic circuits in psoriasis". The Journal of Investigative Dermatology. 131 (3): 677–87. doi:10.1038/jid.2010.340. PMID 21085185.
^Miossec P, Korn T, Kuchroo VK (August 2009). "Interleukin-17 and type 17 helper T cells". The New England Journal of Medicine. 361 (9): 888–98. doi:10.1056/NEJMra0707449. PMID 19710487.
^Martin DA, Towne JE, Kricorian G, Klekotka P, Gudjonsson JE, Krueger JG, Russell CB (January 2013). "The emerging role of IL-17 in the pathogenesis of psoriasis: preclinical and clinical findings". The Journal of Investigative Dermatology. 133 (1): 17–26. doi:10.1038/jid.2012.194. PMC 3568997. PMID 22673731.
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