positive regulation of calcidiol 1-monooxygenase activity
negative regulation of insulin receptor signaling pathway
cellular response to mechanical stimulus
positive regulation of interleukin-8 production
positive regulation of mitotic nuclear division
response to carbohydrate
embryo implantation
regulation of I-kappaB kinase/NF-kappaB signaling
negative regulation of cell population proliferation
apoptotic process
cellular response to organic substance
positive regulation of phagocytosis
regulation of insulin secretion
neutrophil chemotaxis
positive regulation of transcription, DNA-templated
positive regulation of protein export from nucleus
positive regulation of prostaglandin secretion
positive regulation of myosin light chain kinase activity
negative regulation of MAP kinase activity
positive regulation of T cell proliferation
positive regulation of interleukin-6 production
inflammatory response
negative regulation of lipid metabolic process
sequestering of triglyceride
hyaluronan biosynthetic process
positive regulation of heterotypic cell-cell adhesion
positive regulation of lipid catabolic process
cellular response to organic cyclic compound
positive regulation of fever generation
positive regulation of DNA-binding transcription factor activity
positive regulation of angiogenesis
response to lipopolysaccharide
positive regulation of NF-kappaB transcription factor activity
positive regulation of granulocyte macrophage colony-stimulating factor production
immune response
ectopic germ cell programmed cell death
leukocyte migration
lipopolysaccharide-mediated signaling pathway
positive regulation of vascular endothelial growth factor receptor signaling pathway
positive regulation of cell adhesion molecule production
response to ATP
monocyte aggregation
protein kinase B signaling
positive regulation of nitric oxide biosynthetic process
cell-cell signaling
positive regulation of monocyte chemotactic protein-1 production
regulation of nitric-oxide synthase activity
positive regulation of membrane protein ectodomain proteolysis
positive regulation of interferon-gamma production
MAPK cascade
positive regulation of histone acetylation
positive regulation of gene expression
negative regulation of glucose transmembrane transport
interleukin-1 beta production
positive regulation of T cell mediated immunity
extrinsic apoptotic signaling pathway in absence of ligand
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of vascular endothelial growth factor production
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
negative regulation of lipid catabolic process
negative regulation of adiponectin secretion
regulation of establishment of endothelial barrier
positive regulation of cell division
signal transduction
positive regulation of transcription by RNA polymerase II
cytokine-mediated signaling pathway
regulation of defense response to virus by host
fever generation
positive regulation of JNK cascade
positive regulation of cell population proliferation
regulation of signaling receptor activity
positive regulation of epithelial to mesenchymal transition
positive regulation of cell migration
interleukin-6 production
astrocyte activation
regulation of neurogenesis
negative regulation of neurogenesis
negative regulation of synaptic transmission
positive regulation of glial cell proliferation
regulation of ERK1 and ERK2 cascade
interleukin-1-mediated signaling pathway
cellular response to lipopolysaccharide
positive regulation of neuroinflammatory response
positive regulation of p38MAPK cascade
positive regulation of NIK/NF-kappaB signaling
positive regulation of T-helper 1 cell cytokine production
positive regulation of prostaglandin biosynthetic process
positive regulation of complement activation
positive regulation of inflammatory response
response to interleukin-1
positive regulation of RNA biosynthetic process
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
3553
16176
Ensembl
ENSG00000125538
ENSMUSG00000027398
UniProt
P01584
P10749
RefSeq (mRNA)
NM_000576
NM_008361
RefSeq (protein)
NP_000567
NP_032387
Location (UCSC)
Chr 2: 112.83 – 112.84 Mb
Chr 2: 129.21 – 129.21 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Interleukin-1 beta (IL-1β) also known as leukocytic pyrogen, leukocytic endogenous mediator, mononuclear cell factor, lymphocyte activating factor and other names, is a cytokine protein that in humans is encoded by the IL1B gene.[5][6][7][8] There are two genes for interleukin-1 (IL-1): IL-1 alpha and IL-1 beta (this gene). IL-1β precursor is cleaved by cytosolic caspase 1 (interleukin 1 beta convertase) to form mature IL-1β.
^ abcGRCh38: Ensembl release 89: ENSG00000125538 - Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000027398 - Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Auron PE, Webb AC, Rosenwasser LJ, Mucci SF, Rich A, Wolff SM, Dinarello CA (December 1984). "Nucleotide sequence of human monocyte interleukin 1 precursor cDNA". Proceedings of the National Academy of Sciences of the United States of America. 81 (24): 7907–7911. Bibcode:1984PNAS...81.7907A. doi:10.1073/pnas.81.24.7907. PMC 392262. PMID 6083565.
^"Catabolin" is the name given by Jeremy Saklatvala for IL-1 alpha. March CJ, Mosley B, Larsen A, Cerretti DP, Braedt G, Price V, et al. (1985). "Cloning, sequence and expression of two distinct human interleukin-1 complementary DNAs". Nature. 315 (6021): 641–647. Bibcode:1985Natur.315..641M. doi:10.1038/315641a0. PMID 2989698. S2CID 4240002.
^Clark BD, Collins KL, Gandy MS, Webb AC, Auron PE (October 1986). "Genomic sequence for human prointerleukin 1 beta: possible evolution from a reverse transcribed prointerleukin 1 alpha gene". Nucleic Acids Research. 14 (20): 7897–7914. doi:10.1093/nar/14.20.7897. PMC 311823. PMID 3490654.
cytokines that mediate immune responses. Interleukin1 alpha and interleukin1beta (IL1 alpha and IL1 beta) are cytokines that participate in the regulation...
Caspase-1/Interleukin-1 converting enzyme (ICE) is an evolutionarily conserved enzyme that proteolytically cleaves other proteins, such as the precursors...
with similar properties to the mammalian interleukin-1-beta converting enzyme (ICE) (now known as caspase 1). At the time, ICE was the only known caspase...
antibody targeted at interleukin-1beta. It has no cross-reactivity with other members of the interleukin-1 family, including interleukin-1 alpha. Common side...
osteoarthritis (swelling and pain in the joints). It works by inhibiting interleukin-1beta. An updated 2014 Cochrane review found diacerein had a small beneficial...
Sulfonylureas are also used experimentally to inhibit release of interleukin1beta from the NALP3 (or NLRP3) inflammasome. Sulfonylureas – as opposed...
Interleukin 12 (IL-12) is an interleukin that is naturally produced by dendritic cells, macrophages, neutrophils, helper T cells and human B-lymphoblastoid...
pro-inflammatory cytokines tumor necrosis factor-alpha, interleukin-1beta, interleukin-6 and interleukin-8 in the pathogenesis of the otitis media with effusion"...
related to interleukin1-beta. Both families have the same beta trefoil fold consisting of 12-stranded beta-sheet structure, with the beta-sheets are...
lethal factor was presumed to cause macrophages to make TNF-alpha and interleukin1, beta (IL1B). TNF-alpha is a cytokine whose primary role is to regulate...
to interleukin-1beta (IL-1beta), a pro-inflammatory cytokine, and downmodulates the cellular signaling events that produce inflammation. IL-1beta has...
experimental evidence that methotrexate blocks the binding of interleukin1beta to the interleukin1 receptor on target cells". European Journal of Clinical...
Shaham and Junying Yuan working in Horvitz's laboratory identified interleukin-1-beta-converting enzyme as the mammalian homolog of the CED-3 enzyme. In...
Interleukin 10 (IL-10), also known as human cytokine synthesis inhibitory factor (CSIF), is an anti-inflammatory cytokine. In humans, interleukin 10 is...