negative regulation of endothelial cell apoptotic process
negative regulation of complement-dependent cytotoxicity
negative regulation of transforming growth factor beta production
positive regulation of lung goblet cell differentiation
response to mechanical stimulus
response to nicotine
positive regulation of release of sequestered calcium ion into cytosol
microglial cell activation
negative regulation of NAD(P)H oxidase activity
cellular response to mechanical stimulus
response to lipopolysaccharide
negative regulation of lung ciliated cell differentiation
positive regulation of ion transport
immune response
positive regulation of protein secretion
positive regulation of connective tissue growth factor production
positive regulation of pancreatic stellate cell proliferation
response to ethanol
inflammatory response
regulation of proton transport
positive regulation of smooth muscle cell proliferation
negative regulation of neuron death
positive regulation of immunoglobulin production
positive regulation of B cell proliferation
positive regulation of macrophage activation
positive regulation of mast cell degranulation
cellular response to cytokine stimulus
positive regulation of tyrosine phosphorylation of STAT protein
regulation of signaling receptor activity
cytokine-mediated signaling pathway
positive regulation of gene expression
positive regulation of cold-induced thermogenesis
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
3596
16163
Ensembl
ENSG00000169194
ENSMUSG00000020383
UniProt
P35225
P20109
RefSeq (mRNA)
NM_002188
NM_008355
RefSeq (protein)
NP_002179 NP_001341920 NP_001341921 NP_001341922
NP_032381
Location (UCSC)
n/a
Chr 11: 53.52 – 53.53 Mb
PubMed search
[2]
[3]
Wikidata
View/Edit Human
View/Edit Mouse
Interleukin 13 (IL-13) is a protein that in humans is encoded by the IL13 gene.[4][5][6] IL-13 was first cloned in 1993 and is located on chromosome 5q31.1 with a length of 1.4kb.[4] It has a mass of 13 kDa and folds into 4 alpha helical bundles.[7] The secondary structural features of IL-13 are similar to that of Interleukin 4 (IL-4); however it only has 25% sequence identity to IL-4 and is capable of IL-4 independent signaling.[7][4][8] IL-13 is a cytokine secreted by T helper type 2 (Th2) cells, CD4 cells, natural killer T cell, mast cells, basophils, eosinophils and nuocytes.[7] Interleukin-13 is a central regulator in IgE synthesis, goblet cell hyperplasia, mucus hypersecretion, airway hyperresponsiveness, fibrosis and chitinase up-regulation.[7] It is a mediator of allergic inflammation and different diseases including asthma.[7]
^ abcGRCm38: Ensembl release 89: ENSMUSG00000020383 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ abcMinty A, Chalon P, Derocq JM, Dumont X, Guillemot JC, Kaghad M, et al. (March 1993). "Interleukin-13 is a new human lymphokine regulating inflammatory and immune responses". Nature. 362 (6417): 248–250. Bibcode:1993Natur.362..248M. doi:10.1038/362248a0. PMID 8096327. S2CID 4368915.
^McKenzie AN, Culpepper JA, de Waal Malefyt R, Brière F, Punnonen J, Aversa G, et al. (April 1993). "Interleukin 13, a T-cell-derived cytokine that regulates human monocyte and B-cell function". Proceedings of the National Academy of Sciences of the United States of America. 90 (8): 3735–3739. Bibcode:1993PNAS...90.3735M. doi:10.1073/pnas.90.8.3735. PMC 46376. PMID 8097324.
^Morgan JG, Dolganov GM, Robbins SE, Hinton LM, Lovett M (October 1992). "The selective isolation of novel cDNAs encoded by the regions surrounding the human interleukin 4 and 5 genes". Nucleic Acids Research. 20 (19): 5173–5179. doi:10.1093/nar/20.19.5173. PMC 334302. PMID 1408833.
^ abcdeRael EL, Lockey RF (March 2011). "Interleukin-13 signaling and its role in asthma". The World Allergy Organization Journal. 4 (3): 54–64. doi:10.1097/WOX.0b013e31821188e0. PMC 3651056. PMID 23283176.
^Zurawski G, de Vries JE (January 1994). "Interleukin 13, an interleukin 4-like cytokine that acts on monocytes and B cells, but not on T cells". Immunology Today. 15 (1): 19–26. doi:10.1016/0167-5699(94)90021-3. PMID 7907877.
Interleukin13 (IL-13) is a protein that in humans is encoded by the IL13 gene. IL-13 was first cloned in 1993 and is located on chromosome 5q31.1 with...
Interleukins (ILs) are a group of cytokines (secreted proteins and signal molecules) that are expressed and secreted by white blood cells (leukocytes)...
Interleukin 6 (IL-6) is an interleukin that acts as both a pro-inflammatory cytokine and an anti-inflammatory myokine. In humans, it is encoded by the...
The interleukin 4 (IL4, IL-4) is a cytokine that induces differentiation of naive helper T cells (Th0 cells) to Th2 cells. Upon activation by IL-4, Th2 cells...
Interleukin 12 (IL-12) is an interleukin that is naturally produced by dendritic cells, macrophages, neutrophils, helper T cells and human B-lymphoblastoid...
Interleukin-2 (IL-2) is an interleukin, a type of cytokine signaling molecule in the immune system. It is a 15.5–16 kDa protein that regulates the activities...
Interleukin 5 (IL-5) is an interleukin produced by type-2 T helper cells and mast cells. Through binding to the interleukin-5 receptor, interleukin 5...
Interleukin 23 (IL-23) is a heterodimeric cytokine composed of an IL-12B (IL-12p40) subunit (which is shared with IL-12) and an IL-23A (IL-23p19) subunit...
Interleukin-18 (IL-18), also known as interferon-gamma inducing factor is a protein which in humans is encoded by the IL18 gene. The protein encoded by...
the brand name Dupixent, is a monoclonal antibody blocking interleukin 4 and interleukin13, used for allergic diseases such as atopic dermatitis (eczema)...
Interleukin 33 (IL-33) is a protein that in humans is encoded by the IL33 gene. Interleukin 33 is a member of the IL-1 family that potently drives production...
Interleukin 17 family (IL17 family) is a family of pro-inflammatory cystine knot cytokines. They are produced by a group of T helper cell known as T helper...
Interleukin 7 (IL-7) is a protein that in humans is encoded by the IL7 gene. IL-7 is a hematopoietic growth factor secreted by stromal cells in the bone...
Interleukin 8 (IL-8 or chemokine (C-X-C motif) ligand 8, CXCL8) is a chemokine produced by macrophages and other cell types such as epithelial cells,...
The Interleukin-2 receptor alpha chain (also called TAC antigen, P55, and mainly CD25) is a protein involved in the assembly of the high-affinity Interleukin-2...
Interleukin 10 (IL-10), also known as human cytokine synthesis inhibitory factor (CSIF), is an anti-inflammatory cytokine. In humans, interleukin 10 is...
Interleukin-15 (IL-15) is a protein that in humans is encoded by the IL15 gene. IL-15 is an inflammatory cytokine with structural similarity to Interleukin-2...
Interleukin 3 (IL-3) is a protein that in humans is encoded by the IL3 gene localized on chromosome 5q31.1. Sometimes also called colony-stimulating factor...
two subunits of the cytokine Interleukin-23. Interleukin-23 (IL-23) is a heterodimeric cytokine composed of an Interleukin 23 alpha subunit and an IL-12p40...
Cendakimab (RPC4046; ABT 308; CC-93538) is a monoclonal antibody against interleukin13. It is developed by Bristol Myers Squibb for eosinophilic esophagitis...
ankylosing spondylitis, and psoriatic arthritis. It binds to the protein interleukin (IL)-17A and is marketed by Novartis. Secukinumab is used to treat psoriasis...
Global Information
