Interleukin 33 (IL-33) is a protein that in humans is encoded by the IL33 gene.[5]
Interleukin 33 is a member of the IL-1 family that potently drives production of T helper-2 (Th2)-associated cytokines (e.g., IL-4). IL33 is a ligand for ST2 (IL1RL1), an IL-1 family receptor that is highly expressed on Th2 cells, mast cells and group 2 innate lymphocytes.[6]
IL-33 is expressed by a wide variety of cell types, including fibroblasts, mast cells, dendritic cells, macrophages, osteoblasts, endothelial cells, and epithelial cells.[7]
^ abcGRCh38: Ensembl release 89: ENSG00000137033 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000024810 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Entrez Gene: Interleukin 33".
^Yagami A, Orihara K, Morita H, Futamura K, Hashimoto N, Matsumoto K, et al. (November 2010). "IL-33 mediates inflammatory responses in human lung tissue cells". Journal of Immunology. 185 (10): 5743–50. doi:10.4049/jimmunol.0903818. PMID 20926795. S2CID 27317847.
^Mirchandani AS, Salmond RJ, Liew FY (August 2012). "Interleukin-33 and the function of innate lymphoid cells". Trends in Immunology. 33 (8): 389–96. doi:10.1016/j.it.2012.04.005. PMID 22609147.
Interleukin33 (IL-33) is a protein that in humans is encoded by the IL33 gene. Interleukin33 is a member of the IL-1 family that potently drives production...
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