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Secukinumab information


Secukinumab
Autoinjector with Cosentyx by Novartis (Secukinumab)
Monoclonal antibody
TypeWhole antibody
SourceHuman
TargetIL17A
Clinical data
Trade namesCosentyx
Other namesAIN457
AHFS/Drugs.comMonograph
MedlinePlusa615011
License data
  • US DailyMed: Secukinumab
Pregnancy
category
  • AU: C
Routes of
administration
Subcutaneous, intravenous
ATC code
  • L04AC10 (WHO)
Legal status
Legal status
  • AU: S4 (Prescription only)[1][2]
  • CA: ℞-only[3]
  • UK: POM (Prescription only)[4]
  • US: ℞-only[5]
  • EU: Rx-only[6]
  • In general: ℞ (Prescription only)
Identifiers
CAS Number
  • 875356-43-7 checkY (heavy chain)
    875356-44-8 (light chain)
DrugBank
  • DB09029 ☒N
ChemSpider
  • none
UNII
  • DLG4EML025
KEGG
  • D09967
Chemical and physical data
FormulaC6584H10134N1754O2042S44
Molar mass147944.37 g·mol−1
 ☒NcheckY (what is this?)  (verify)

Secukinumab, sold under the brand name Cosentyx among others, is a human IgG1κ monoclonal antibody used for the treatment of psoriasis, ankylosing spondylitis, and psoriatic arthritis.[4][5][6] It binds to the protein interleukin (IL)-17A and is marketed by Novartis.[4][5][6]

  1. ^ "Cosentyx (Novartis Pharmaceuticals Australia Pty Ltd)". Therapeutic Goods Administration (TGA). 7 October 2022. Retrieved 9 April 2023.
  2. ^ "Prescription medicines: registration of new chemical entities in Australia, 2015". Therapeutic Goods Administration (TGA). 21 June 2022. Retrieved 10 April 2023.
  3. ^ "Health Canada New Drug Authorizations: 2015 Highlights". Health Canada. 4 May 2016. Retrieved 7 April 2024.
  4. ^ a b c "Cosentyx 150mg and 300mg solution for injection in pre-filled syringe and pre-filled pen - Summary of Product Characteristics (SmPC)". (emc). 6 June 2022. Retrieved 9 November 2022.
  5. ^ a b c "Cosentyx- secukinumab injection". DailyMed. 4 November 2022. Retrieved 9 November 2022.
  6. ^ a b c Cite error: The named reference Cosentyx EPAR was invoked but never defined (see the help page).

and 24 Related for: Secukinumab information

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Secukinumab

Last Update:

Secukinumab, sold under the brand name Cosentyx among others, is a human IgG1κ monoclonal antibody used for the treatment of psoriasis, ankylosing spondylitis...

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Bimekizumab

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demonstrated that bimekizumab is superior to not only adalimumab but also secukinumab and ustekinumab for the treatment of plaque psoriasis. "Bimzelx APMDS"...

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Psoriatic arthritis

Last Update:

well as the IL-12/IL-23 inhibitor ustekinumab, the IL-17A inhibitor secukinumab, and the IL-23 inhibitor risankizumab. Biologics may increase the risk...

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Catheter

Last Update:

Woessner, Ralph; Pieber, Thomas Rudolf; Cheng, Yi (November 23, 2015). "Secukinumab distributes into dermal interstitial fluid of psoriasis patients as demonstrated...

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Ankylosing spondylitis

Last Update:

this class target IL-17, an important part of the inflammatory system: secukinumab and ixekizumab. They are often considered in cases where TNFi drugs are...

Word Count : 5991

ATC code L04

Last Update:

L04AC07 Tocilizumab L04AC08 Canakinumab L04AC09 Briakinumab L04AC10 Secukinumab L04AC11 Siltuximab L04AC12 Brodalumab L04AC13 Ixekizumab L04AC14 Sarilumab...

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Dupilumab

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(interleukin 25), F) Antibodies: Brodalumab Ixekizumab Perakizumab Remtolumab Secukinumab Vunakizumab IL-18 Agonists: Iboctadekin Interleukin 18 Interleukin 37...

Word Count : 1841

Hidradenitis suppurativa

Last Update:

changes. In May 2023, the European Commission (EC) approved Cosentyx (secukinumab) for active moderate to severe hidradenitis suppurativa in adults. Other...

Word Count : 5433

Psoriasis

Last Update:

severe cases of psoriasis. There is also some evidence to support use of secukinumab, brodalumab, guselkumab, certolizumab, and ustekinumab. In general, anti-IL17...

Word Count : 12972

Avacincaptad pegol

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Netakimab Olokizumab Rilonacept Risankizumab Sarilumab Satralizumab Secukinumab Siltuximab Sirukumab Spesolimab Tildrakizumab Tocilizumab Ustekinumab...

Word Count : 299

Novartis

Last Update:

(uncomplicated) Comtan (entacapone) Parkinson's disease 530 2012 −14% Cosentyx (secukinumab) Psoriasis Diovan (valsartan) Hypertension 4,417 2012 −22% Entresto...

Word Count : 11963

Ustekinumab

Last Update:

(interleukin 25), F) Antibodies: Brodalumab Ixekizumab Perakizumab Remtolumab Secukinumab Vunakizumab IL-18 Agonists: Iboctadekin Interleukin 18 Interleukin 37...

Word Count : 1922

Guselkumab

Last Update:

(interleukin 25), F) Antibodies: Brodalumab Ixekizumab Perakizumab Remtolumab Secukinumab Vunakizumab IL-18 Agonists: Iboctadekin Interleukin 18 Interleukin 37...

Word Count : 1017

Injector pen

Last Update:

antibodies available or studied as injector pens include adalimumab, secukinumab, and alirocumab. CGRP antagonists which are monoclonal antibodies, used...

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CD4

Last Update:

(interleukin 25), F) Antibodies: Brodalumab Ixekizumab Perakizumab Remtolumab Secukinumab Vunakizumab IL-18 Agonists: Iboctadekin Interleukin 18 Interleukin 37...

Word Count : 2577

Interleukin 1 beta

Last Update:

(interleukin 25), F) Antibodies: Brodalumab Ixekizumab Perakizumab Remtolumab Secukinumab Vunakizumab IL-18 Agonists: Iboctadekin Interleukin 18 Interleukin 37...

Word Count : 3305

Anakinra

Last Update:

(interleukin 25), F) Antibodies: Brodalumab Ixekizumab Perakizumab Remtolumab Secukinumab Vunakizumab IL-18 Agonists: Iboctadekin Interleukin 18 Interleukin 37...

Word Count : 2070

Benralizumab

Last Update:

(interleukin 25), F) Antibodies: Brodalumab Ixekizumab Perakizumab Remtolumab Secukinumab Vunakizumab IL-18 Agonists: Iboctadekin Interleukin 18 Interleukin 37...

Word Count : 267

Interleukin 4

Last Update:

(interleukin 25), F) Antibodies: Brodalumab Ixekizumab Perakizumab Remtolumab Secukinumab Vunakizumab IL-18 Agonists: Iboctadekin Interleukin 18 Interleukin 37...

Word Count : 2293

Interleukin 6

Last Update:

(interleukin 25), F) Antibodies: Brodalumab Ixekizumab Perakizumab Remtolumab Secukinumab Vunakizumab IL-18 Agonists: Iboctadekin Interleukin 18 Interleukin 37...

Word Count : 7480

Interleukin 12

Last Update:

(interleukin 25), F) Antibodies: Brodalumab Ixekizumab Perakizumab Remtolumab Secukinumab Vunakizumab IL-18 Agonists: Iboctadekin Interleukin 18 Interleukin 37...

Word Count : 1578

Interleukin 5

Last Update:

(interleukin 25), F) Antibodies: Brodalumab Ixekizumab Perakizumab Remtolumab Secukinumab Vunakizumab IL-18 Agonists: Iboctadekin Interleukin 18 Interleukin 37...

Word Count : 1478

Interleukin 8

Last Update:

(interleukin 25), F) Antibodies: Brodalumab Ixekizumab Perakizumab Remtolumab Secukinumab Vunakizumab IL-18 Agonists: Iboctadekin Interleukin 18 Interleukin 37...

Word Count : 2761

Monoclonal antibody therapy

Last Update:

intravenous chimeric CD20 B-cell non-Hodgkin's lymphoma 103705 Link secukinumab Cosentyx Novartis 1/21/2015 subcutaneous fully human IL17A Plaque psoriasis...

Word Count : 4064

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