positive regulation of activated T cell proliferation
apoptotic process
regulation of regulatory T cell differentiation
cytokine-mediated signaling pathway
interleukin-2-mediated signaling pathway
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
3559
16184
Ensembl
ENSG00000134460
ENSMUSG00000026770
UniProt
P01589
P01590
RefSeq (mRNA)
NM_000417 NM_001308242 NM_001308243
NM_008367
RefSeq (protein)
NP_000408 NP_001295171 NP_001295172
NP_032393
Location (UCSC)
Chr 10: 6.01 – 6.06 Mb
Chr 2: 11.65 – 11.7 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
The Interleukin-2 receptor alpha chain (also called TAC antigen, P55, and mainly CD25) is a protein involved in the assembly of the high-affinity Interleukin-2 receptor, consisting of alpha (IL2RA), beta (IL2RB) and the common gamma chain (IL2RG). As the name indicates, this receptor interacts with Interleukin-2, a pleiotropic cytokine which plays an important role in immune homeostasis.[5][6]
^ abcGRCh38: Ensembl release 89: ENSG00000134460 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000026770 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Spolski R, Li P, Leonard WJ (October 2018). "Biology and regulation of IL-2: from molecular mechanisms to human therapy". Nature Reviews. Immunology. 18 (10): 648–659. doi:10.1038/s41577-018-0046-y. PMID 30089912. S2CID 51939991.
^Zhou P (October 2022). "Emerging mechanisms and applications of low-dose IL-2 therapy in autoimmunity". Cytokine & Growth Factor Reviews. 67: 80–88. doi:10.1016/j.cytogfr.2022.06.003. PMID 35803833. S2CID 250200065.
assembly of the high-affinity Interleukin-2 receptor, consisting of alpha (IL2RA), beta (IL2RB) and the common gamma chain (IL2RG). As the name indicates...
express high amount of high affinity IL-2 receptor α chain (CD25) encoded by Il2ra gene which gather IL-2 from thymic medulla, and decrease its concentration...
induce acute phase reaction, large amounts induce fever IL-2 Th1-cells CD25/IL2RA, CD122/IL2RB, CD132/IL2RG activated T cells and B cells, NK cells, macrophages...
761049 Link basiliximab Simulect Novartis 5/12/1998 intravenous chimeric IL2RA Prophylaxis of acute organ rejection in renal transplant 103764 Link belimumab...
human interleukin-15 receptor alpha chain and close linkage of IL15RA and IL2RA genes". The Journal of Biological Chemistry. 270 (50): 29862–29869. doi:10...
disorder associated with mutations in the interleukin 2 receptor alpha (CD25) (IL2RA) gene. The mutations cause expression of a defective α chain or complete...