positive regulation of natural killer cell proliferation
sleep
regulation of cell adhesion
positive regulation of NK T cell proliferation
positive regulation of granulocyte macrophage colony-stimulating factor production
positive regulation of tissue remodeling
angiogenesis
T-helper 1 type immune response
positive regulation of interleukin-17 production
inflammatory response
lipopolysaccharide-mediated signaling pathway
positive regulation of activated T cell proliferation
positive regulation of protein kinase B signaling
positive regulation of phosphatidylinositol 3-kinase signaling
positive regulation of smooth muscle cell proliferation
activation of protein kinase B activity
positive regulation of transcription by RNA polymerase II
positive regulation of tyrosine phosphorylation of STAT protein
positive regulation of gene expression
positive regulation of macrophage derived foam cell differentiation
natural killer cell activation
positive regulation of interferon-gamma production
cholesterol homeostasis
positive regulation of T-helper 2 cell differentiation
negative regulation of myoblast differentiation
triglyceride homeostasis
cell population proliferation
regulation of signaling receptor activity
interleukin-6 production
T-helper 1 cell cytokine production
neutrophil activation
natural killer cell mediated cytotoxicity
cytokine-mediated signaling pathway
interleukin-18-mediated signaling pathway
positive regulation of NIK/NF-kappaB signaling
immune response
positive regulation of NF-kappaB transcription factor activity
positive regulation of T-helper 1 cell cytokine production
positive regulation of cold-induced thermogenesis
positive regulation of neuroinflammatory response
signal transduction
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
3606
16173
Ensembl
ENSG00000150782
ENSMUSG00000039217
UniProt
Q14116
P70380
RefSeq (mRNA)
NM_001243211 NM_001562 NM_001386420
NM_008360 NM_001357221 NM_001357222
RefSeq (protein)
NP_001230140 NP_001553 NP_001230140.1
NP_032386 NP_001344150 NP_001344151
Location (UCSC)
Chr 11: 112.14 – 112.16 Mb
Chr 9: 50.47 – 50.49 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Interleukin-18 (IL-18), also known as interferon-gamma inducing factor is a protein which in humans is encoded by the IL18 gene.[5][6] The protein encoded by this gene is a proinflammatory cytokine. Many cell types, both hematopoietic cells and non-hematopoietic cells, have the potential to produce IL-18. It was first described in 1989 as a factor that induced interferon-γ (IFN-γ) production in mouse spleen cells.[7] Originally, IL-18 production was recognized in Kupffer cells, and liver-resident macrophages. However, IL-18 is constitutively expressed in non-hematopoietic cells, such as intestinal epithelial cells, keratinocytes, and endothelial cells.[8] IL-18 can modulate both innate and adaptive immunity and its dysregulation can cause autoimmune or inflammatory diseases.[9][10]
^ abcGRCh38: Ensembl release 89: ENSG00000150782 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000039217 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Okamura H, Tsutsi H, Komatsu T, Yutsudo M, Hakura A, Tanimoto T, et al. (November 1995). "Cloning of a new cytokine that induces IFN-gamma production by T cells". Nature. 378 (6552): 88–91. Bibcode:1995Natur.378...88O. doi:10.1038/378088a0. PMID 7477296. S2CID 4323405.
^Nolan KF, Greaves DR, Waldmann H (July 1998). "The human interleukin 18 gene IL18 maps to 11q22.2-q22.3, closely linked to the DRD2 gene locus and distinct from mapped IDDM loci". Genomics. 51 (1): 161–3. doi:10.1006/geno.1998.5336. PMID 9693051.
^Nakamura K, Okamura H, Wada M, Nagata K, Tamura T (February 1989). "Endotoxin-induced serum factor that stimulates gamma interferon production". Infection and Immunity. 57 (2): 590–5. doi:10.1128/IAI.57.2.590-595.1989. PMC 313137. PMID 2492265.
^Yasuda K, Nakanishi K, Tsutsui H (February 2019). "Interleukin-18 in Health and Disease". International Journal of Molecular Sciences. 20 (3): 649. doi:10.3390/ijms20030649. PMC 6387150. PMID 30717382.
^Baker KJ, Houston A, Brint E (2019). "IL-1 Family Members in Cancer; Two Sides to Every Story". Frontiers in Immunology. 10: 1197. doi:10.3389/fimmu.2019.01197. PMC 6567883. PMID 31231372.
^Fabbi M, Carbotti G, Ferrini S (April 2015). "Context-dependent role of IL-18 in cancer biology and counter-regulation by IL-18BP". Journal of Leukocyte Biology. 97 (4): 665–75. doi:10.1189/jlb.5RU0714-360RR. PMID 25548255. S2CID 25636657.
Interleukin-18 (IL-18), also known as interferon-gamma inducing factor is a protein which in humans is encoded by the IL18 gene. The protein encoded by...
Interleukins (ILs) are a group of cytokines (secreted proteins and signal molecules) that are expressed and secreted by white blood cells (leukocytes)...
Interleukin 6 (IL-6) is an interleukin that acts as both a pro-inflammatory cytokine and an anti-inflammatory myokine. In humans, it is encoded by the...
Interleukin 12 (IL-12) is an interleukin that is naturally produced by dendritic cells, macrophages, neutrophils, helper T cells and human B-lymphoblastoid...
Interleukin 5 (IL-5) is an interleukin produced by type-2 T helper cells and mast cells. Through binding to the interleukin-5 receptor, interleukin 5...
Interleukin-2 (IL-2) is an interleukin, a type of cytokine signaling molecule in the immune system. It is a 15.5–16 kDa protein that regulates the activities...
Interleukin-15 (IL-15) is a protein that in humans is encoded by the IL15 gene. IL-15 is an inflammatory cytokine with structural similarity to Interleukin-2...
The interleukin 4 (IL4, IL-4) is a cytokine that induces differentiation of naive helper T cells (Th0 cells) to Th2 cells. Upon activation by IL-4, Th2 cells...
Interleukin 10 (IL-10), also known as human cytokine synthesis inhibitory factor (CSIF), is an anti-inflammatory cytokine. In humans, interleukin 10 is...
two subunits of the cytokine Interleukin-23. Interleukin-23 (IL-23) is a heterodimeric cytokine composed of an Interleukin 23 alpha subunit and an IL-12p40...
Interleukin 8 (IL-8 or chemokine (C-X-C motif) ligand 8, CXCL8) is a chemokine produced by macrophages and other cell types such as epithelial cells,...
Interleukin 7 (IL-7) is a protein that in humans is encoded by the IL7 gene. IL-7 is a hematopoietic growth factor secreted by stromal cells in the bone...
Interleukin 23 (IL-23) is a heterodimeric cytokine composed of an IL-12B (IL-12p40) subunit (which is shared with IL-12) and an IL-23A (IL-23p19) subunit...
Interleukin 17 family (IL17 family) is a family of pro-inflammatory cystine knot cytokines. They are produced by a group of T helper cell known as T helper...
The Interleukin-2 receptor alpha chain (also called TAC antigen, P55, and mainly CD25) is a protein involved in the assembly of the high-affinity Interleukin-2...
Interleukin 13 (IL-13) is a protein that in humans is encoded by the IL13 gene. IL-13 was first cloned in 1993 and is located on chromosome 5q31.1 with...
Interleukin 33 (IL-33) is a protein that in humans is encoded by the IL33 gene. Interleukin 33 is a member of the IL-1 family that potently drives production...
Interleukin-22 (IL-22) is protein that in humans is encoded by the IL22 gene. IL-22 is an α-helical cytokine. IL-22 binds to a heterodimeric cell surface...
Interleukin 37 (IL-37), also known as Interleukin-1 family member 7 (IL-1F7), is an anti-inflammatory cytokine important for the downregulation of pro-inflammatory...
Interleukin 3 (IL-3) is a protein that in humans is encoded by the IL3 gene localized on chromosome 5q31.1. Sometimes also called colony-stimulating factor...
caspase 7, which activate the inflammatory cytokine interleukin-1β. Interleukin-1β and interleukin-18 are expressed at high levels in people with vitiligo...
Global Information
