negative regulation of smooth muscle cell proliferation
cell maturation
extrathymic T cell selection
positive regulation of T cell proliferation
regulation of defense response to virus by host
positive regulation of inflammatory response
response to nutrient levels
positive regulation of protein O-linked glycosylation
positive regulation of interleukin-17 production
hyaluronan metabolic process
positive regulation of natural killer cell differentiation
regulation of T cell differentiation
positive regulation of tissue remodeling
cellular response to vitamin D
lymph node development
natural killer cell differentiation
positive regulation of natural killer cell proliferation
cell-cell signaling
skeletal muscle atrophy
signal transduction
human ageing
NK T cell proliferation
positive regulation of immune response
inflammatory response
immune response
positive regulation of cell population proliferation
tyrosine phosphorylation of STAT protein
positive regulation of tyrosine phosphorylation of STAT protein
regulation of signaling receptor activity
interleukin-15-mediated signaling pathway
neutrophil activation
positive regulation of peptidyl-tyrosine phosphorylation
positive regulation of phagocytosis
negative regulation of cold-induced thermogenesis
macrophage differentiation
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
3600
16168
Ensembl
ENSG00000164136
ENSMUSG00000031712
UniProt
P40933
P48346
RefSeq (mRNA)
NM_000585 NM_172174 NM_172175
NM_001254747 NM_008357
RefSeq (protein)
NP_000576 NP_751915
NP_001241676 NP_032383
Location (UCSC)
Chr 4: 141.64 – 141.73 Mb
Chr 8: 83.06 – 83.13 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Interleukin-15 (IL-15) is a protein that in humans is encoded by the IL15 gene. IL-15 is an inflammatory cytokine with structural similarity to Interleukin-2 (IL-2). Like IL-2, IL-15 binds to and signals through a complex composed of IL-2/IL-15 receptor beta chain (CD122) and the common gamma chain (gamma-C, CD132). IL-15 is secreted by mononuclear phagocytes (and some other cells) following infection by virus(es). This cytokine induces the proliferation of natural killer cells, i.e. cells of the innate immune system whose principal role is to kill virally infected cells.
^ abcGRCh38: Ensembl release 89: ENSG00000164136 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000031712 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Interleukin-15 (IL-15) is a protein that in humans is encoded by the IL15 gene. IL-15 is an inflammatory cytokine with structural similarity to Interleukin-2...
Interleukins (ILs) are a group of cytokines (secreted proteins and signal molecules) that are expressed and secreted by white blood cells (leukocytes)...
Interleukin-2 (IL-2) is an interleukin, a type of cytokine signaling molecule in the immune system. It is a 15.5–16 kDa protein that regulates the activities...
myokine, myostatin, was identified. The gp130 receptor cytokine IL-6 (Interleukin 6) was the first myokine found to be secreted into the blood stream in...
Interleukin 6 (IL-6) is an interleukin that acts as both a pro-inflammatory cytokine and an anti-inflammatory myokine. In humans, it is encoded by the...
Interleukin 12 (IL-12) is an interleukin that is naturally produced by dendritic cells, macrophages, neutrophils, helper T cells and human B-lymphoblastoid...
The interleukin 4 (IL4, IL-4) is a cytokine that induces differentiation of naive helper T cells (Th0 cells) to Th2 cells. Upon activation by IL-4, Th2 cells...
Interleukin 5 (IL-5) is an interleukin produced by type-2 T helper cells and mast cells. Through binding to the interleukin-5 receptor, interleukin 5...
Interleukin 8 (IL-8 or chemokine (C-X-C motif) ligand 8, CXCL8) is a chemokine produced by macrophages and other cell types such as epithelial cells,...
The Interleukin-2 receptor alpha chain (also called TAC antigen, P55, and mainly CD25) is a protein involved in the assembly of the high-affinity Interleukin-2...
Interleukin 10 (IL-10), also known as human cytokine synthesis inhibitory factor (CSIF), is an anti-inflammatory cytokine. In humans, interleukin 10 is...
combination medication used for the treatment of bladder cancer. It is an interleukin-15 receptor agonist. It is given in combination with Bacillus Calmette-Guérin...
Interleukin 13 (IL-13) is a protein that in humans is encoded by the IL13 gene. IL-13 was first cloned in 1993 and is located on chromosome 5q31.1 with...
Interleukin 33 (IL-33) is a protein that in humans is encoded by the IL33 gene. Interleukin 33 is a member of the IL-1 family that potently drives production...
Interleukin 23 (IL-23) is a heterodimeric cytokine composed of an IL-12B (IL-12p40) subunit (which is shared with IL-12) and an IL-23A (IL-23p19) subunit...
Interleukin-18 (IL-18), also known as interferon-gamma inducing factor is a protein which in humans is encoded by the IL18 gene. The protein encoded by...
Interleukin 16 is a pro-inflammatory pleiotropic cytokine. Its precursor, pro-interleukin-16 is a protein that in humans is encoded by the IL16 gene....
receptor complexes for at least six different interleukin receptors: IL-2, IL-4, IL-7, IL-9, IL-15 and interleukin-21 receptor. The γc glycoprotein is a member...
Interleukin 7 (IL-7) is a protein that in humans is encoded by the IL7 gene. IL-7 is a hematopoietic growth factor secreted by stromal cells in the bone...
Interleukin 17 family (IL17 family) is a family of pro-inflammatory cystine knot cytokines. They are produced by a group of T helper cell known as T helper...
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