IL1RL1 information

IL1RL1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4KC3
Identifiers
Aliases	IL1RL1, DER4, FIT-1, IL33R, ST2, ST2L, ST2V, T1, interleukin 1 receptor like 1
External IDs	OMIM: 601203; MGI: 98427; HomoloGene: 2862; GeneCards: IL1RL1; OMA:IL1RL1 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	102,352,037 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	40,504,575 bp
RNA expression pattern
	Top expressed in
	upper lobe of left lung; ; right lung; ; lower lobe of lung; ; left adrenal gland; ; right adrenal gland; ; kidney; ; body of stomach; ; metanephric glomerulus; ; gallbladder; ; sperm;
	Top expressed in
	duodenum; ; lip; ; ileum; ; jejunum; ; esophagus; ; stomach; ; axial skeleton; ; extraocular muscle; ; rib; ; blastocyst;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	interleukin-33 receptor activity; interleukin-1 receptor activity; cytokine receptor activity; protein binding; interleukin-33 binding;
Cellular component	integral component of membrane; external side of plasma membrane; membrane; extracellular region; plasma membrane; extracellular matrix;
Biological process	negative regulation of T-helper 1 type immune response; positive regulation of inflammatory response; negative regulation of interferon-gamma production; positive regulation of macrophage activation; negative regulation of I-kappaB kinase/NF-kappaB signaling; signal transduction; immune response; positive regulation of interleukin-5 production; interleukin-33-mediated signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	9173
	17082
	ENSG00000115602
	ENSMUSG00000026069
	Q01638
	P14719
	NM_001282408; NM_003856; NM_016232; NM_173459
	NM_001025602; NM_001294171; NM_010743
	NP_001269337; NP_003847; NP_057316
	NP_001020773; NP_001281100; NP_034873
	Wikidata
View/Edit Human	View/Edit Mouse

Interleukin 1 receptor-like 1, also known as IL1RL1 and ST2, is a protein that in humans is encoded by the IL1RL1 gene.^[5]^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000115602 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026069 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: IL1RL1 interleukin 1 receptor-like 1".
^ Tominaga S, Yokota T, Yanagisawa K, Tsukamoto T, Takagi T, Tetsuka T (December 1992). "Nucleotide sequence of a complementary DNA for human ST2". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1171 (2): 215–8. doi:10.1016/0167-4781(92)90125-j. PMID 1482686.
^ Dale M, Nicklin MJ (April 1999). "Interleukin-1 receptor cluster: gene organization of IL1R2, IL1R1, IL1RL2 (IL-1Rrp2), IL1RL1 (T1/ST2), and IL18R1 (IL-1Rrp) on human chromosome 2q". Genomics. 57 (1): 177–9. doi:10.1006/geno.1999.5767. PMID 10191101.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000115602 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026069 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: IL1RL1 interleukin 1 receptor-like 1".

[pmid1482686-6] Tominaga S, Yokota T, Yanagisawa K, Tsukamoto T, Takagi T, Tetsuka T (December 1992). "Nucleotide sequence of a complementary DNA for human ST2". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1171 (2): 215–8. doi:10.1016/0167-4781(92)90125-j. PMID 1482686.

[pmid10191101-7] Dale M, Nicklin MJ (April 1999). "Interleukin-1 receptor cluster: gene organization of IL1R2, IL1R1, IL1RL2 (IL-1Rrp2), IL1RL1 (T1/ST2), and IL18R1 (IL-1Rrp) on human chromosome 2q". Genomics. 57 (1): 177–9. doi:10.1006/geno.1999.5767. PMID 10191101.

IL1RL1 information

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