positive regulation of receptor signaling pathway via JAK-STAT
positive regulation of transcription by RNA polymerase II
positive regulation of stress-activated MAPK cascade
positive regulation of ERK1 and ERK2 cascade
negative regulation of epithelial cell proliferation
regulation of signaling receptor activity
cytokine-mediated signaling pathway
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
55801
n/a
Ensembl
ENSG00000111536
n/a
UniProt
Q9NPH9
n/a
RefSeq (mRNA)
NM_018402
n/a
RefSeq (protein)
NP_060872
n/a
Location (UCSC)
Chr 12: 68.2 – 68.23 Mb
n/a
PubMed search
[2]
n/a
Wikidata
View/Edit Human
Interleukin-26 (IL-26) is a protein that in humans is encoded by the IL26 gene.[3][4][5]
IL-26 is the most recently identified member of the IL-20 cytokine subfamily,[6] which was formed according to the usage of common receptor subunits and similarities in target-cell profiles and functions. All cytokines belonging to this subfamily are members of the larger IL-10 family. IL-26 is expressed in certain herpesvirus-transformed T cells but not in primary stimulated T cells.[4] IL-26 signals through a receptor complex comprising two distinct proteins called IL-20 receptor 1 and IL-10 receptor 2.[7] By signaling through this receptor complex, IL-26 induces rapid phosphorylation of the transcription factors STAT1 and STAT3, which enhance IL-10 and IL-8 secretion and as expression of the CD54 molecule on the surface of epithelial cells.[8]
^ abcGRCh38: Ensembl release 89: ENSG00000111536 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Entrez Gene: interleukin 26".
^ abKnappe A, Hör S, Wittmann S, Fickenscher H (April 2000). "Induction of a novel cellular homolog of interleukin-10, AK155, by transformation of T lymphocytes with herpesvirus saimiri". Journal of Virology. 74 (8): 3881–7. doi:10.1128/JVI.74.8.3881-3887.2000. PMC 111897. PMID 10729163.
^Goris A, Marrosu MG, Vandenbroeck K (August 2001). "Novel polymorphisms in the IL-10 related AK155 gene (chromosome 12q15)". Genes and Immunity. 2 (5): 284–6. doi:10.1038/sj.gene.6363772. PMID 11528524. S2CID 11291286.
^Larochette V, Miot C, Poli C, Beaumont E, Roingeard P, Fickenscher H, et al. (2019-02-12). "IL-26, a Cytokine With Roles in Extracellular DNA-Induced Inflammation and Microbial Defense". Frontiers in Immunology. 10: 204. doi:10.3389/fimmu.2019.00204. PMC 6379347. PMID 30809226.
^Sheikh F, Baurin VV, Lewis-Antes A, Shah NK, Smirnov SV, Anantha S, et al. (February 2004). "Cutting edge: IL-26 signals through a novel receptor complex composed of IL-20 receptor 1 and IL-10 receptor 2". Journal of Immunology. 172 (4): 2006–10. doi:10.4049/jimmunol.172.4.2006. PMID 14764663.
^Hör S, Pirzer H, Dumoutier L, Bauer F, Wittmann S, Sticht H, et al. (August 2004). "The T-cell lymphokine interleukin-26 targets epithelial cells through the interleukin-20 receptor 1 and interleukin-10 receptor 2 chains". The Journal of Biological Chemistry. 279 (32): 33343–51. doi:10.1074/jbc.M405000200. PMID 15178681.
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