Family of proteins involved in anatomical development
Fibroblast growth factors (FGF) are a family of cell signalling proteins produced by macrophages; they are involved in a wide variety of processes, most notably as crucial elements for normal development in animal cells. Any irregularities in their function lead to a range of developmental defects. These growth factors typically act as systemic or locally circulating molecules of extracellular origin that activate cell surface receptors. A defining property of FGFs is that they bind to heparin and to heparan sulfate. Thus, some are sequestered in the extracellular matrix of tissues that contains heparan sulfate proteoglycans and are released locally upon injury or tissue remodeling.[1]
^Burgess WH, Maciag T (1989). "The heparin-binding (fibroblast) growth factor family of proteins". Annu Rev Biochem. 58: 575–606. doi:10.1146/annurev.bi.58.070189.003043. PMID 2549857.
and 29 Related for: Fibroblast growth factor information
Fibroblastgrowthfactors (FGF) are a family of cell signalling proteins produced by macrophages; they are involved in a wide variety of processes, most...
The fibroblastgrowthfactor receptors (FGFR) are, as their name implies, receptors that bind to members of the fibroblastgrowthfactor (FGF) family of...
Fibroblastgrowthfactor 23 (FGF23) is a protein and member of the fibroblastgrowthfactor (FGF) family which participates in the regulation of phosphate...
Fibroblastgrowthfactor 8 (FGF-8) is a protein that in humans is encoded by the FGF8 gene. The protein encoded by this gene is a member of the fibroblast...
Fibroblastgrowthfactor receptor 2 (FGFR2) also known as CD332 (cluster of differentiation 332) is a protein that in humans is encoded by the FGFR2 gene...
Fibroblastgrowthfactor receptor 3 is a protein that in humans is encoded by the FGFR3 gene. FGFR3 has also been designated as CD333 (cluster of differentiation...
Fibroblastgrowthfactor 18 (FGF18) is a protein that is encoded by the Fgf18 gene in humans. The protein was first discovered in 1998, when two newly-identified...
Fibroblastgrowthfactor 5 is a protein that in humans is encoded by the FGF5 gene. The majority of FGF family members are glycosaminoglycan binding proteins...
cell culture system, rat kidney fibroblasts. Application of the transforming growthfactors to normal rat kidney fibroblasts induces the cultured cells to...
the epithelium. KGF is a small signaling molecule that binds to fibroblastgrowthfactor receptor 2b (FGFR2b). For signalling to occur, a dimer is required...
Fibroblastgrowthfactor receptor 4 is a protein that in humans is encoded by the FGFR4 gene. FGFR4 has also been designated as CD334 (cluster of differentiation...
This article is about the role of FibroblastGrowthFactor Signaling in Mesoderm Formation. Mesoderm formation is a complex developmental process involving...
and big toes. Pfeiffer syndrome is caused by mutations in the fibroblastgrowthfactor receptors FGFR1 and FGFR2. The syndrome is grouped into three types:...
similar structures: fibroblastgrowthfactor (FGF) family, Hedgehog family, Wnt family, and TGF-β superfamily. Binding of a paracrine factor to its respective...
Fibroblastgrowthfactor 10 is a protein that in humans is encoded by the FGF10 gene. The protein encoded by this gene is a member of the fibroblast growth...
(INN) (developmental code name AS-902330), is a recombinant human fibroblastgrowthfactor 18 (rhFGF18) analog, which is under development by TrialSpark for...
Fibroblastgrowthfactor 4 is a protein that in humans is encoded by the FGF4 gene. The protein encoded by this gene is a member of the fibroblast growth...
Fibroblastgrowthfactor receptor substrate 3 is a protein that in humans is encoded by the FRS3 gene. The protein encoded by this gene is a substrate...
Activation of other growth factor receptors such as fibroblastgrowthfactor receptors or epidermal growthfactor receptor can also be responsible. Acanthosis...
Fibroblastgrowthfactor 19 is a protein that in humans is encoded by the FGF19 gene. It functions as a hormone, regulating bile acid synthesis, with effects...
Fibroblastgrowthfactor 12 is a protein that in humans is encoded by the FGF12 gene. The protein encoded by this gene is a member of the fibroblast growth...
Global Information