Fibroblast growth factor receptor 2 information

FGFR2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1DJS, 1E0O, 1EV2, 1GJO, 1II4, 1IIL, 1NUN, 1OEC, 1WVZ, 2FDB, 2PSQ, 2PVF, 2PVY, 2PWL, 2PY3, 2PZ5, 2PZP, 2PZR, 2Q0B, 3B2T, 3CAF, 3CLY, 3CU1, 3DAR, 3EUU, 3OJ2, 3OJM, 3RI1, 4J95, 4J96, 4J97, 4J98, 4J99, 4J23, 4WV1
Identifiers
Aliases	FGFR2, BBDS, BEK, BFR-1, CD332, CEK3, CFD1, ECT1, JWS, K-SAM, KGFR, TK14, TK25, fibroblast growth factor receptor 2
External IDs	OMIM: 176943 MGI: 95523 HomoloGene: 22566 GeneCards: FGFR2
Gene location (Human)
Chr.	Chromosome 10 (human)
End	121,598,458 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	132,725,079 bp
RNA expression pattern
	Top expressed in
	corpus callosum; ; inferior olivary nucleus; ; parotid gland; ; inferior ganglion of vagus nerve; ; external globus pallidus; ; subthalamic nucleus; ; substantia nigra; ; putamen; ; retinal pigment epithelium; ; pons;
	Top expressed in
	calvaria; ; adrenal gland; ; left lung lobe; ; retinal pigment epithelium; ; medullary collecting duct; ; wall of esophagus; ; superior surface of tongue; ; epithelium of esophagus; ; ciliary body; ; lip;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	heparin binding; kinase activity; transmembrane receptor protein tyrosine kinase activity; fibroblast growth factor binding; ATP binding; protein kinase activity; fibroblast growth factor-activated receptor activity; transferase activity; protein homodimerization activity; protein binding; nucleotide binding; protein tyrosine kinase activity; 1-phosphatidylinositol-3-kinase activity; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; identical protein binding; receptor tyrosine kinase; transmembrane signaling receptor activity;
Cellular component	cytoplasm; membrane; extracellular region; nucleus; cell surface; integral component of membrane; Golgi apparatus; intracellular membrane-bounded organelle; extracellular matrix; plasma membrane; nucleoplasm; cell cortex; integral component of plasma membrane; excitatory synapse; cytoplasmic vesicle; receptor complex; collagen-containing extracellular matrix;
Biological process	fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development; ureteric bud development; organ growth; limb bud formation; embryonic pattern specification; bud elongation involved in lung branching; positive regulation of canonical Wnt signaling pathway; membranous septum morphogenesis; fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow; embryonic organ morphogenesis; post-embryonic development; squamous basal epithelial stem cell differentiation involved in prostate gland acinus development; branching morphogenesis of a nerve; reproductive structure development; fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow cell; ventricular cardiac muscle tissue morphogenesis; protein phosphorylation; positive regulation of cardiac muscle cell proliferation; mesenchymal cell differentiation; positive regulation of mesenchymal cell proliferation; regulation of osteoblast differentiation; prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis; angiogenesis; prostate gland morphogenesis; positive regulation of ERK1 and ERK2 cascade; orbitofrontal cortex development; negative regulation of epithelial cell proliferation; animal organ morphogenesis; embryonic digestive tract morphogenesis; hair follicle morphogenesis; morphogenesis of embryonic epithelium; branch elongation involved in salivary gland morphogenesis; apoptotic process; branching involved in salivary gland morphogenesis; cell fate commitment; lung development; embryonic organ development; fibroblast growth factor receptor signaling pathway involved in hemopoiesis; in utero embryonic development; lateral sprouting from an epithelium; positive regulation of Wnt signaling pathway; gland morphogenesis; positive regulation of cell cycle; branching involved in labyrinthine layer morphogenesis; branching involved in prostate gland morphogenesis; regulation of ERK1 and ERK2 cascade; protein autophosphorylation; mammary gland bud formation; pyramidal neuron development; lacrimal gland development; positive regulation of MAPK cascade; regulation of smooth muscle cell differentiation; regulation of cell fate commitment; bone mineralization; regulation of branching involved in prostate gland morphogenesis; positive regulation of epithelial cell proliferation involved in lung morphogenesis; epithelial cell differentiation; phosphorylation; multicellular organism growth; positive regulation of epithelial cell proliferation; ventricular zone neuroblast division; epidermis morphogenesis; skeletal system morphogenesis; regulation of morphogenesis of a branching structure; negative regulation of transcription by RNA polymerase II; outflow tract septum morphogenesis; odontogenesis; epithelial to mesenchymal transition; lung alveolus development; lung lobe morphogenesis; midbrain development; positive regulation of smooth muscle cell proliferation; fibroblast growth factor receptor signaling pathway involved in mammary gland specification; mesenchymal cell proliferation involved in lung development; prostate epithelial cord elongation; mesenchymal cell differentiation involved in lung development; axonogenesis; regulation of multicellular organism growth; otic vesicle formation; epithelial cell proliferation involved in salivary gland morphogenesis; cell-cell signaling; regulation of fibroblast growth factor receptor signaling pathway; bone morphogenesis; MAPK cascade; regulation of osteoblast proliferation; positive regulation of phospholipase activity; fibroblast growth factor receptor signaling pathway; regulation of smoothened signaling pathway; inner ear morphogenesis; positive regulation of cell population proliferation; mesodermal cell differentiation; peptidyl-tyrosine phosphorylation; digestive tract development; lung-associated mesenchyme development; bone development; positive regulation of cell division; positive regulation of transcription by RNA polymerase II; phosphatidylinositol phosphate biosynthetic process; phosphatidylinositol-3-phosphate biosynthetic process; endochondral bone growth; response to lipopolysaccharide; wound healing; cellular response to fibroblast growth factor stimulus; response to ethanol; cellular response to retinoic acid; cellular response to transforming growth factor beta stimulus; embryonic cranial skeleton morphogenesis; positive regulation of protein kinase B signaling; negative regulation of signal transduction; cell differentiation; negative regulation of apoptotic process; transmembrane receptor protein tyrosine kinase signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	2263
	14183
	ENSG00000066468
	ENSMUSG00000030849
	P21802
	P21803
NM_000141; NM_001144913; NM_001144914; NM_001144915; NM_001144916;
	NM_001144917; NM_001144918; NM_001144919; NM_022970; NM_022971; NM_022972; NM_022973; NM_022974; NM_022975; NM_022976; NM_023028; NM_023029; NM_023030; NM_001320654; NM_001320658; NM_023031
	NM_010207; NM_201601; NM_001347638
NP_000132; NP_001138385; NP_001138386; NP_001138387; NP_001138388;
	NP_001138389; NP_001138390; NP_001138391; NP_001307583; NP_001307587; NP_075259; NP_075418
	NP_001334567; NP_034337; NP_963895
	Wikidata
View/Edit Human	View/Edit Mouse

Fibroblast growth factor receptor 2 (FGFR2) also known as CD332 (cluster of differentiation 332) is a protein that in humans is encoded by the FGFR2 gene residing on chromosome 10.^[5]^[6] FGFR2 is a receptor for fibroblast growth factor.

The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution.^[7] FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member is a high-affinity receptor for acidic, basic and/or keratinocyte growth factor, depending on the isoform.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000066468 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000030849 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Houssaint E, Blanquet PR, Champion-Arnaud P, Gesnel MC, Torriglia A, Courtois Y, Breathnach R (Oct 1990). "Related fibroblast growth factor receptor genes exist in the human genome". Proceedings of the National Academy of Sciences of the United States of America. 87 (20): 8180–4. Bibcode:1990PNAS...87.8180H. doi:10.1073/pnas.87.20.8180. PMC 54916. PMID 2172978.
^ Dionne CA, Crumley G, Bellot F, Kaplow JM, Searfoss G, Ruta M, Burgess WH, Jaye M, Schlessinger J (Sep 1990). "Cloning and expression of two distinct high-affinity receptors cross-reacting with acidic and basic fibroblast growth factors". The EMBO Journal. 9 (9): 2685–92. doi:10.1002/j.1460-2075.1990.tb07454.x. PMC 551973. PMID 1697263.
^ "Entrez Gene: FGFR2 fibroblast growth factor receptor 2 (bacteria-expressed kinase, keratinocyte growth factor receptor, craniofacial dysostosis 1, Crouzon syndrome, Pfeiffer syndrome, Jackson–Weiss syndrome)".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000066468 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000030849 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2172978-5] Houssaint E, Blanquet PR, Champion-Arnaud P, Gesnel MC, Torriglia A, Courtois Y, Breathnach R (Oct 1990). "Related fibroblast growth factor receptor genes exist in the human genome". Proceedings of the National Academy of Sciences of the United States of America. 87 (20): 8180–4. Bibcode:1990PNAS...87.8180H. doi:10.1073/pnas.87.20.8180. PMC 54916. PMID 2172978.

[pmid1697263-6] Dionne CA, Crumley G, Bellot F, Kaplow JM, Searfoss G, Ruta M, Burgess WH, Jaye M, Schlessinger J (Sep 1990). "Cloning and expression of two distinct high-affinity receptors cross-reacting with acidic and basic fibroblast growth factors". The EMBO Journal. 9 (9): 2685–92. doi:10.1002/j.1460-2075.1990.tb07454.x. PMC 551973. PMID 1697263.

[7] "Entrez Gene: FGFR2 fibroblast growth factor receptor 2 (bacteria-expressed kinase, keratinocyte growth factor receptor, craniofacial dysostosis 1, Crouzon syndrome, Pfeiffer syndrome, Jackson–Weiss syndrome)".

Fibroblast growth factor receptor 2 information

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Fibroblast growth factor receptor 2

Fibroblast growth factor receptor

Fibroblast growth factor

Fibroblast growth factor receptor 1

Basic fibroblast growth factor

Fibroblast growth factor receptor 3

Fibroblast growth factor 23

Growth factor

Fibroblast growth factor receptor 4

Fibroblast growth factor 21

Epidermal growth factor receptor

Fibroblast growth factor 8

Transforming growth factor

Pfeiffer syndrome

Keratinocyte growth factor

Receptor tyrosine kinase

FGF1

Crouzon syndrome

Hepatocyte growth factor

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Transforming growth factor beta

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Fibroblast growth factor and mesoderm formation