positive regulation of vitamin D 24-hydroxylase activity
phosphate-containing compound metabolic process
vitamin D catabolic process
positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway
cellular response to parathyroid hormone stimulus
negative regulation of hormone secretion
phosphatidylinositol phosphate biosynthetic process
peptidyl-tyrosine phosphorylation
phosphatidylinositol-3-phosphate biosynthetic process
MAPK cascade
post-translational protein modification
regulation of signaling receptor activity
positive regulation of protein kinase B signaling
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
8074
64654
Ensembl
ENSG00000118972
ENSMUSG00000000182
UniProt
Q9GZV9
Q9EPC2
RefSeq (mRNA)
NM_020638
NM_022657
RefSeq (protein)
NP_065689
NP_073148
Location (UCSC)
Chr 12: 4.37 – 4.38 Mb
Chr 6: 127.05 – 127.06 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Fibroblast growth factor 23 (FGF23) is a protein and member of the fibroblast growth factor (FGF) family which participates in the regulation of phosphate in plasma and vitamin D metabolism. In humans it is encoded by the FGF23 gene. FGF23 decreases reabsorption of phosphate in the kidney. Mutations in FGF23 can lead to its increased activity, resulting in autosomal dominant hypophosphatemic rickets.
^ abcGRCh38: Ensembl release 89: ENSG00000118972 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000000182 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
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tubules. The mutated PHEX gene causes pathological elevations in fibroblastgrowthfactor23 (FGF23), a hormone that regulates phosphate homeostasis by decreasing...
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(such as hypocalcemia). Calcitriol Increase in serum phosphate. Fibroblastgrowthfactor-23 (FGF23) is produced in osteoblasts (from bone) in response to...
rickets. caused by overproduction of a hormone called FGF23 (fibroblastgrowthfactor23) in bone cells. FGF23 is responsible for blocking phosphate re-absorption...