FRS3 information

FRS3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2KUP, 2KUQ, 2YS5, 2YT2
Identifiers
Aliases	FRS3, FRS2-beta, FRS2B, FRS2beta, SNT-2, SNT2, fibroblast growth factor receptor substrate 3
External IDs	OMIM: 607744; MGI: 2135965; HomoloGene: 4845; GeneCards: FRS3; OMA:FRS3 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	41,786,542 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	48,015,211 bp
RNA expression pattern
	Top expressed in
	prefrontal cortex; ; Brodmann area 9; ; hypothalamus; ; amygdala; ; substantia nigra; ; hippocampus proper; ; nucleus accumbens; ; ganglionic eminence; ; superior frontal gyrus; ; putamen;
	Top expressed in
	spermatocyte; ; yolk sac; ; cerebellar cortex; ; superior frontal gyrus; ; paraventricular nucleus of hypothalamus; ; seminiferous tubule; ; dorsomedial hypothalamic nucleus; ; lateral hypothalamus; ; proximal tubule; ; medial vestibular nucleus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; fibroblast growth factor receptor binding; identical protein binding;
Cellular component	plasma membrane; membrane; intracellular anatomical structure;
Biological process	fibroblast growth factor receptor signaling pathway; signal transduction; MAPK cascade;
	Sources:Amigo / QuickGO
Orthologs
	10817
	107971
	ENSG00000137218
	ENSMUSG00000023266
	O43559
	Q91WJ0
	NM_006653
	NM_144939
	NP_006644
	NP_659188
	Wikidata
View/Edit Human	View/Edit Mouse

Fibroblast growth factor receptor substrate 3 is a protein that in humans is encoded by the FRS3 gene.^[5]^[6]^[7]

The protein encoded by this gene is a substrate for the fibroblast growth factor receptor. It is found in peripheral plasma membrane and functions in linking FGF receptor stimulation to activators of Ras.^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000137218 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000023266 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Wang JK, Xu H, Li HC, Goldfarb M (Oct 1996). "Broadly expressed SNT-like proteins link FGF receptor stimulation to activators of Ras". Oncogene. 13 (4): 721–9. PMID 8761293.
^ Xu H, Lee KW, Goldfarb M (Aug 1998). "Novel recognition motif on fibroblast growth factor receptor mediates direct association and activation of SNT adapter proteins". J Biol Chem. 273 (29): 17987–90. doi:10.1074/jbc.273.29.17987. PMID 9660748.
^ ^a ^b "Entrez Gene: FRS3 fibroblast growth factor receptor substrate 3".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000137218 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000023266 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8761293-5] Wang JK, Xu H, Li HC, Goldfarb M (Oct 1996). "Broadly expressed SNT-like proteins link FGF receptor stimulation to activators of Ras". Oncogene. 13 (4): 721–9. PMID 8761293.

[pmid9660748-6] Xu H, Lee KW, Goldfarb M (Aug 1998). "Novel recognition motif on fibroblast growth factor receptor mediates direct association and activation of SNT adapter proteins". J Biol Chem. 273 (29): 17987–90. doi:10.1074/jbc.273.29.17987. PMID 9660748.

[entrez-7] "Entrez Gene: FRS3 fibroblast growth factor receptor substrate 3".