FGF18 information

FGF18
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4CJM
Identifiers
Aliases	FGF18, FGF-18, ZFGF5, fibroblast growth factor 18
External IDs	OMIM: 603726 MGI: 1277980 HomoloGene: 2867 GeneCards: FGF18
Gene location (Human)
Chr.	Chromosome 5 (human)
End	171,457,626 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	33,097,400 bp
RNA expression pattern
	Top expressed in
	right ventricle; ; vena cava; ; parietal pleura; ; endothelial cell; ; synovial joint; ; visceral pleura; ; pericardium; ; right coronary artery; ; germinal epithelium; ; hair follicle;
	Top expressed in
	internal carotid artery; ; aortic valve; ; external carotid artery; ; facial motor nucleus; ; coronal suture; ; trigeminal ganglion; ; morula; ; medial vestibular nucleus; ; left lung lobe; ; parietal bone;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	fibroblast growth factor receptor binding; type 1 fibroblast growth factor receptor binding; type 2 fibroblast growth factor receptor binding; growth factor activity; protein tyrosine kinase activity; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; 1-phosphatidylinositol-3-kinase activity;
Cellular component	extracellular region; nucleolus; extracellular space;
Biological process	intramembranous ossification; positive regulation of vascular endothelial growth factor receptor signaling pathway; regulation of sprouting angiogenesis; positive regulation of endothelial cell chemotaxis to fibroblast growth factor; positive regulation of MAP kinase activity; ossification; lung development; cell-cell signaling; anatomical structure morphogenesis; chondrocyte development; endochondral ossification; MAPK cascade; fibroblast growth factor receptor signaling pathway; positive regulation of chondrocyte differentiation; angiogenesis; positive regulation of cell population proliferation; regulation of endothelial cell proliferation; signal transduction; phosphatidylinositol phosphate biosynthetic process; peptidyl-tyrosine phosphorylation; phosphatidylinositol-3-phosphate biosynthetic process; regulation of signaling receptor activity; positive regulation of protein kinase B signaling; positive regulation of blood vessel endothelial cell migration; positive regulation of angiogenesis; positive regulation of ERK1 and ERK2 cascade;
	Sources:Amigo / QuickGO
Orthologs
	8817
	14172
	ENSG00000156427
	ENSMUSG00000057967
	O76093
	O89101
	NM_033649; NM_003862
	NM_008005
	NP_003853
	NP_032031
	Wikidata
View/Edit Human	View/Edit Mouse

Fibroblast growth factor 18 (FGF18) is a protein that is encoded by the Fgf18 gene in humans.^[5]^[6]^[7] The protein was first discovered in 1998, when two newly-identified murine genes Fgf17 and Fgf18 were described and confirmed as being closely related by sequence homology to Fgf8.^[8] The three proteins were eventually grouped into the FGF8 subfamily, which contains several of the endocrine FGF superfamily members FGF8, FGF17, and FGF18.^[9] Subsequent studies identified FGF18's role in promoting chondrogenesis,^[10] and an apparent specific activity for the generation of the hyaline cartilage in articular joints.^[11]

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, and tissue repair. It has been shown in vitro that this protein is able to induce neurite outgrowth in PC12 cells.^[12]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000156427 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000057967 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Ohbayashi N, Hoshikawa M, Kimura S, Yamasaki M, Fukui S, Itoh N (Aug 1998). "Structure and expression of the mRNA encoding a novel fibroblast growth factor, FGF-18". J Biol Chem. 273 (29): 18161–4. doi:10.1074/jbc.273.29.18161. PMID 9660775.
^ Hu MC, Qiu WR, Wang YP, Hill D, Ring BD, Scully S, Bolon B, DeRose M, Luethy R, Simonet WS, Arakawa T, Danilenko DM (Nov 1998). "FGF-18, a Novel Member of the Fibroblast Growth Factor Family, Stimulates Hepatic and Intestinal Proliferation". Mol Cell Biol. 18 (10): 6063–74. doi:10.1128/MCB.18.10.6063. PMC 109192. PMID 9742123.
^ "Entrez Gene: FGF18 fibroblast growth factor 18".
^ Maruoka Y, Ohbayashi N, Hoshikawa M, Itoh N, Hogan BL, Furuta Y (June 1998). "Comparison of the expression of three highly related genes, Fgf8, Fgf17 and Fgf18, in the mouse embryo". Mechanisms of Development. 74 (1–2): 175–177. doi:10.1016/s0925-4773(98)00061-6. ISSN 0925-4773. PMID 9651520. S2CID 18400935.
^ Itoh N, Ornitz DM (November 2004). "Evolution of the Fgf and Fgfr gene families". Trends in Genetics. 20 (11): 563–569. doi:10.1016/j.tig.2004.08.007. ISSN 0168-9525. PMID 15475116.
^ Moore EE, Bendele AM, Thompson DL, Littau A, Waggie KS, Reardon B, Ellsworth JL (July 2005). "Fibroblast growth factor-18 stimulates chondrogenesis and cartilage repair in a rat model of injury-induced osteoarthritis". Osteoarthritis and Cartilage. 13 (7): 623–631. doi:10.1016/j.joca.2005.03.003. ISSN 1063-4584. PMID 15896984.
^ Hollander JM, Goraltchouk A, Rawal M, Liu J, Luppino F, Zeng L, Seregin A (2023-03-06). "Adeno-Associated Virus-Delivered Fibroblast Growth Factor 18 Gene Therapy Promotes Cartilage Anabolism". Cartilage. 14 (4): 492–505. doi:10.1177/19476035231158774. ISSN 1947-6043. PMC 10807742. PMID 36879540. S2CID 257376179.
^ Ohbayashi N, Hoshikawa M, Kimura S, Yamasaki M, Fukui S, Itoh N (1998-07-17). "Structure and expression of the mRNA encoding a novel fibroblast growth factor, FGF-18". The Journal of Biological Chemistry. 273 (29): 18161–18164. doi:10.1074/jbc.273.29.18161. ISSN 0021-9258. PMID 9660775.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000156427 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000057967 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9660775-5] Ohbayashi N, Hoshikawa M, Kimura S, Yamasaki M, Fukui S, Itoh N (Aug 1998). "Structure and expression of the mRNA encoding a novel fibroblast growth factor, FGF-18". J Biol Chem. 273 (29): 18161–4. doi:10.1074/jbc.273.29.18161. PMID 9660775.

[pmid9742123-6] Hu MC, Qiu WR, Wang YP, Hill D, Ring BD, Scully S, Bolon B, DeRose M, Luethy R, Simonet WS, Arakawa T, Danilenko DM (Nov 1998). "FGF-18, a Novel Member of the Fibroblast Growth Factor Family, Stimulates Hepatic and Intestinal Proliferation". Mol Cell Biol. 18 (10): 6063–74. doi:10.1128/MCB.18.10.6063. PMC 109192. PMID 9742123.

[entrez-7] "Entrez Gene: FGF18 fibroblast growth factor 18".

[8] Maruoka Y, Ohbayashi N, Hoshikawa M, Itoh N, Hogan BL, Furuta Y (June 1998). "Comparison of the expression of three highly related genes, Fgf8, Fgf17 and Fgf18, in the mouse embryo". Mechanisms of Development. 74 (1–2): 175–177. doi:10.1016/s0925-4773(98)00061-6. ISSN 0925-4773. PMID 9651520. S2CID 18400935.

[9] Itoh N, Ornitz DM (November 2004). "Evolution of the Fgf and Fgfr gene families". Trends in Genetics. 20 (11): 563–569. doi:10.1016/j.tig.2004.08.007. ISSN 0168-9525. PMID 15475116.

[10] Moore EE, Bendele AM, Thompson DL, Littau A, Waggie KS, Reardon B, Ellsworth JL (July 2005). "Fibroblast growth factor-18 stimulates chondrogenesis and cartilage repair in a rat model of injury-induced osteoarthritis". Osteoarthritis and Cartilage. 13 (7): 623–631. doi:10.1016/j.joca.2005.03.003. ISSN 1063-4584. PMID 15896984.

[11] Hollander JM, Goraltchouk A, Rawal M, Liu J, Luppino F, Zeng L, Seregin A (2023-03-06). "Adeno-Associated Virus-Delivered Fibroblast Growth Factor 18 Gene Therapy Promotes Cartilage Anabolism". Cartilage. 14 (4): 492–505. doi:10.1177/19476035231158774. ISSN 1947-6043. PMC 10807742. PMID 36879540. S2CID 257376179.

[12] Ohbayashi N, Hoshikawa M, Kimura S, Yamasaki M, Fukui S, Itoh N (1998-07-17). "Structure and expression of the mRNA encoding a novel fibroblast growth factor, FGF-18". The Journal of Biological Chemistry. 273 (29): 18161–18164. doi:10.1074/jbc.273.29.18161. ISSN 0021-9258. PMID 9660775.

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