FGF4 information

FGF4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1IJT
Identifiers
Aliases	FGF4, HBGF-4, HST, HST-1, HSTF1, K-FGF, KFGF, fibroblast growth factor 4, HSTF-1, FGF-4
External IDs	OMIM: 164980 MGI: 95518 HomoloGene: 1522 GeneCards: FGF4
Gene location (Human)
Chr.	Chromosome 11 (human)
End	69,775,341 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	144,418,980 bp
RNA expression pattern
	Top expressed in
	olfactory bulb; ; tibialis anterior muscle; ; tibial nerve; ; trigeminal ganglion; ; spinal ganglia; ; fundus; ; reproductive system; ; testicle; ; gastrocnemius muscle;
	Top expressed in
	enamel knot; ; primitive streak; ; sciatic nerve; ; inner cell mass; ; endoderm; ; morula; ; surface ectoderm; ; blastocyst; ; mesoderm; ; free upper limb;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	heparin binding; fibroblast growth factor receptor binding; growth factor activity; protein tyrosine kinase activity; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; 1-phosphatidylinositol-3-kinase activity;
Cellular component	extracellular region; intracellular anatomical structure;
Biological process	cartilage condensation; MAPK cascade; negative regulation of apoptotic process; positive regulation of ERK1 and ERK2 cascade; apoptotic process involved in morphogenesis; signal transduction; cell-cell signaling; regulation of endothelial cell chemotaxis to fibroblast growth factor; multicellular organism development; embryonic limb morphogenesis; mesenchymal cell proliferation; positive regulation of cell division; regulation of gene expression; positive regulation of gene expression; stem cell population maintenance; chondroblast differentiation; cranial suture morphogenesis; positive regulation of transcription by RNA polymerase II; cell differentiation; positive regulation of protein phosphorylation; odontogenesis of dentin-containing tooth; embryonic hindlimb morphogenesis; fibroblast growth factor receptor signaling pathway; peptidyl-tyrosine phosphorylation; positive regulation of cell population proliferation; phosphatidylinositol phosphate biosynthetic process; phosphatidylinositol-3-phosphate biosynthetic process; cellular response to leukemia inhibitory factor; regulation of signaling receptor activity; positive regulation of protein kinase B signaling;
	Sources:Amigo / QuickGO
Orthologs
	2249
	14175
	ENSG00000075388
	ENSMUSG00000050917
	P08620
	P11403
	NM_002007
	NM_010202
	NP_001998
	NP_034332
	Wikidata
View/Edit Human	View/Edit Mouse

Fibroblast growth factor 4 is a protein that in humans is encoded by the FGF4 gene.^[5]^[6]

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was identified by its oncogenic transforming activity. This gene and FGF3, another oncogenic growth factor, are located closely on chromosome 11. Co-amplification of both genes was found in various kinds of human tumors. Studies on the mouse homolog suggested a function in bone morphogenesis and limb development through the sonic hedgehog (SHH) signaling pathway.^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000075388 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000050917 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Galland F, Stefanova M, Lafage M, Birnbaum D (Jul 1992). "Localization of the 5' end of the MCF2 oncogene to human chromosome 15q15----q23". Cytogenetics and Cell Genetics. 60 (2): 114–6. doi:10.1159/000133316. PMID 1611909.
^ ^a ^b "Entrez Gene: FGF4 fibroblast growth factor 4 (heparin secretory transforming protein 1, Kaposi sarcoma oncogene)".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000075388 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000050917 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1611909-5] Galland F, Stefanova M, Lafage M, Birnbaum D (Jul 1992). "Localization of the 5' end of the MCF2 oncogene to human chromosome 15q15----q23". Cytogenetics and Cell Genetics. 60 (2): 114–6. doi:10.1159/000133316. PMID 1611909.

[entrez-6] "Entrez Gene: FGF4 fibroblast growth factor 4 (heparin secretory transforming protein 1, Kaposi sarcoma oncogene)".

FGF4 information

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Zone of polarizing activity

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