Basic fibroblast growth factor information

FGF2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1BAS, 1BFB, 1BFC, 1BFF, 1BFG, 1BLA, 1BLD, 1CVS, 1EV2, 1FGA, 1FQ9, 1II4, 1IIL, 2BFH, 2FGF, 2M49, 4FGF, 4OEE, 4OEF, 4OEG
Identifiers
Aliases	FGF2, BFGF, FGF-2, FGFB, HBGF-2, fibroblast growth factor 2
External IDs	OMIM: 134920 MGI: 95516 HomoloGene: 1521 GeneCards: FGF2
Gene location (Human)
Chr.	Chromosome 4 (human)
End	122,898,236 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	37,464,257 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; smooth muscle tissue; ; stromal cell of endometrium; ; adipose tissue; ; retinal pigment epithelium; ; subcutaneous adipose tissue; ; ascending aorta; ; right coronary artery; ; islet of Langerhans; ; popliteal artery;
	Top expressed in
	ascending aorta; ; aortic valve; ; vas deferens; ; ankle; ; epididymis; ; carotid body; ; esophagus; ; urethra; ; white adipose tissue; ; temporal muscle;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	cytokine activity; heparin binding; fibroblast growth factor receptor binding; protein binding; nuclear receptor coactivator activity; chemoattractant activity; growth factor activity; protein tyrosine kinase activity; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; 1-phosphatidylinositol-3-kinase activity; receptor-receptor interaction; integrin binding;
Cellular component	extracellular region; nucleus; extracellular space;
Biological process	release of sequestered calcium ion into cytosol; cell differentiation; negative regulation of fibroblast migration; hyaluronan catabolic process; positive regulation of endothelial cell proliferation; positive regulation of MAP kinase activity; negative regulation of blood vessel endothelial cell migration; positive regulation of endothelial cell chemotaxis to fibroblast growth factor; somatic stem cell population maintenance; positive regulation of phospholipase C activity; extracellular matrix organization; wound healing; negative regulation of cell death; regulation of angiogenesis; nervous system development; cell migration involved in sprouting angiogenesis; MAPK cascade; positive regulation of angiogenesis; positive regulation of phosphatidylinositol 3-kinase activity; positive regulation of transcription, DNA-templated; chemotaxis; fibroblast growth factor receptor signaling pathway; chondroblast differentiation; multicellular organism development; growth factor dependent regulation of skeletal muscle satellite cell proliferation; branching involved in ureteric bud morphogenesis; positive regulation of cardiac muscle cell proliferation; embryonic morphogenesis; angiogenesis; positive regulation of cell fate specification; animal organ morphogenesis; regulation of endothelial cell chemotaxis to fibroblast growth factor; phosphatidylinositol biosynthetic process; inositol phosphate biosynthetic process; negative regulation of wound healing; Ras protein signal transduction; positive regulation of cell division; signal transduction; positive regulation of transcription by RNA polymerase II; positive chemotaxis; phosphatidylinositol phosphate biosynthetic process; peptidyl-tyrosine phosphorylation; positive regulation of sprouting angiogenesis; positive regulation of cell population proliferation; phosphatidylinositol-3-phosphate biosynthetic process; stem cell proliferation; regulation of signaling receptor activity; positive regulation of protein kinase B signaling; cytokine-mediated signaling pathway; positive regulation of blood vessel endothelial cell migration; positive regulation of ERK1 and ERK2 cascade; positive regulation of vascular associated smooth muscle cell proliferation; positive regulation of vascular endothelial cell proliferation; positive regulation of cell migration involved in sprouting angiogenesis; paracrine signaling; positive regulation of DNA biosynthetic process; positive regulation of endothelial cell chemotaxis;
	Sources:Amigo / QuickGO
Orthologs
	2247
	14173
	ENSG00000138685
	ENSMUSG00000037225
	P09038
	P15655
	NM_002006; NM_001361665
	NM_008006
	NP_001997; NP_001348594
	NP_032032
	Wikidata
View/Edit Human	View/Edit Mouse

Fibroblast growth factor 2, also known as basic fibroblast growth factor (bFGF) and FGF-β, is a growth factor and signaling protein encoded by the FGF2 gene.^[5]^[6] It binds to and exerts effects via specific fibroblast growth factor receptor (FGFR) proteins, themselves a family of closely related molecules. Fibroblast growth factor protein was first purified in 1975; soon thereafter three variants were isolated: 'basic FGF' (FGF2); Heparin-binding growth factor-2; and Endothelial cell growth factor-2. Gene sequencing revealed that this group is the same FGF2 protein and is a member of a family of FGF proteins.^[7]^[8]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000138685 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000037225 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Dionne CA, Crumley G, Bellot F, Kaplow JM, Searfoss G, Ruta M, Burgess WH, Jaye M, Schlessinger J (September 1990). "Cloning and expression of two distinct high-affinity receptors cross-reacting with acidic and basic fibroblast growth factors". The EMBO Journal. 9 (9): 2685–92. doi:10.1002/j.1460-2075.1990.tb07454.x. PMC 551973. PMID 1697263.
^ Kim HS (1998). "Assignment1 of the human basic fibroblast growth factor gene FGF2 to chromosome 4 band q26 by radiation hybrid mapping". Cytogenetics and Cell Genetics. 83 (1–2): 73. doi:10.1159/000015129. PMID 9925931. S2CID 33214466.
^ Cite error: The named reference pmid 1785797 was invoked but never defined (see the help page).
^ Burgess WH, Maciag T (1989). "The heparin-binding (fibroblast) growth factor family of proteins". Annual Review of Biochemistry. 58: 575–606. doi:10.1146/annurev.bi.58.070189.003043. PMID 2549857.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000138685 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000037225 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1697263-5] Dionne CA, Crumley G, Bellot F, Kaplow JM, Searfoss G, Ruta M, Burgess WH, Jaye M, Schlessinger J (September 1990). "Cloning and expression of two distinct high-affinity receptors cross-reacting with acidic and basic fibroblast growth factors". The EMBO Journal. 9 (9): 2685–92. doi:10.1002/j.1460-2075.1990.tb07454.x. PMC 551973. PMID 1697263.

[pmid9925931-6] Kim HS (1998). "Assignment1 of the human basic fibroblast growth factor gene FGF2 to chromosome 4 band q26 by radiation hybrid mapping". Cytogenetics and Cell Genetics. 83 (1–2): 73. doi:10.1159/000015129. PMID 9925931. S2CID 33214466.

[pmid_1785797-7] Cite error: The named reference pmid 1785797 was invoked but never defined (see the help page).

[8] Burgess WH, Maciag T (1989). "The heparin-binding (fibroblast) growth factor family of proteins". Annual Review of Biochemistry. 58: 575–606. doi:10.1146/annurev.bi.58.070189.003043. PMID 2549857.

Basic fibroblast growth factor information

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