FGF5 information

FGF5
Identifiers
Aliases	FGF5, HBGF-5, Smag-82, TCMGLY, fibroblast growth factor 5
External IDs	OMIM: 165190 MGI: 95519 HomoloGene: 3283 GeneCards: FGF5
Gene location (Human)
Chr.	Chromosome 4 (human)
End	80,336,680 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	98,424,889 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; cerebellar cortex; ; cerebellar hemisphere; ; gallbladder; ; gastric mucosa; ; internal globus pallidus; ; appendix; ; prefrontal cortex; ; kidney; ; muscle tissue;
	Top expressed in
	hair follicle; ; spiral ganglion; ; endoderm; ; larynx; ; trigeminal ganglion; ; spinal ganglia; ; lip; ; superior frontal gyrus; ; skin of abdomen; ; hippocampus proper;
	More reference expression data
	n/a
Gene ontology
Molecular function	fibroblast growth factor receptor binding; growth factor activity; protein tyrosine kinase activity; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; 1-phosphatidylinositol-3-kinase activity;
Cellular component	extracellular region; intracellular anatomical structure; extracellular space;
Biological process	cell-cell signaling; signal transduction involved in regulation of gene expression; glial cell differentiation; nervous system development; MAPK cascade; fibroblast growth factor receptor signaling pathway; positive regulation of cell population proliferation; cell population proliferation; positive regulation of cell division; phosphatidylinositol phosphate biosynthetic process; peptidyl-tyrosine phosphorylation; phosphatidylinositol-3-phosphate biosynthetic process; regulation of signaling receptor activity; positive regulation of protein kinase B signaling;
	Sources:Amigo / QuickGO
Orthologs
	2250
	14176
	ENSG00000138675
	ENSMUSG00000029337
	P12034
	P15656
	NM_033143; NM_001291812; NM_004464
	NM_001277268; NM_010203
	NP_001278741; NP_004455; NP_149134
	NP_001264197; NP_034333
	Wikidata
View/Edit Human	View/Edit Mouse

Fibroblast growth factor 5 is a protein that in humans is encoded by the FGF5 gene.

The majority of FGF family members are glycosaminoglycan binding proteins which possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. FGF proteins interact with a family of specific tyrosine kinase receptors, a process often regulated by proteoglycans or extracellular binding protein cofactors. A number of intracellular signalling cascades are known to be activated after FGF-FGFR interaction including PI3K-AKT, PLCγ, RAS-MAPK and STAT pathways.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000138675 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000029337 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Ornitz DM, Itoh N (2015). "The Fibroblast Growth Factor signaling pathway". Wiley Interdisciplinary Reviews: Developmental Biology. 4 (3): 215–66. doi:10.1002/wdev.176. PMC 4393358. PMID 25772309.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000138675 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000029337 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Ornitz DM, Itoh N (2015). "The Fibroblast Growth Factor signaling pathway". Wiley Interdisciplinary Reviews: Developmental Biology. 4 (3): 215–66. doi:10.1002/wdev.176. PMC 4393358. PMID 25772309.

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