Protein or other substance that stimulates cellular proliferation
"Growth factors" redirects here. For the journal, see Growth Factors (journal).
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A growth factor is a naturally occurring substance capable of stimulating cell proliferation, wound healing, and occasionally cellular differentiation.[1] Usually it is a secreted protein or a steroid hormone. Growth factors are important for regulating a variety of cellular processes.
Growth factors typically act as signaling molecules between cells. Examples are cytokines and hormones that bind to specific receptors on the surface of their target cells.
They often promote cell differentiation and maturation, which varies between growth factors. For example, epidermal growth factor (EGF) enhances osteogenic differentiation (osteogenesis or bone formation),[2] while fibroblast growth factors and vascular endothelial growth factors stimulate blood vessel differentiation (angiogenesis).
^"growth factor" at Dorland's Medical Dictionary
^Del Angel-Mosqueda C, Gutiérrez-Puente Y, López-Lozano AP, Romero-Zavaleta RE, Mendiola-Jiménez A, Medina-De la Garza CE, Márquez-M M, De la Garza-Ramos MA (September 2015). "Epidermal growth factor enhances osteogenic differentiation of dental pulp stem cells in vitro". Head & Face Medicine. 11: 29. doi:10.1186/s13005-015-0086-5. PMC 4558932. PMID 26334535.
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give rise to. Growthfactors initiate signal transduction pathways, which lead to activation of transcription factors. Growthfactors elicit different...
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in human development. GH also stimulates production of Insulin-like growthfactor 1 (IGF-1) and increases the concentration of glucose and free fatty...
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The keratinocyte growthfactor (KGF), also known as FGF7, is a growthfactor present in the epithelialization-phase of wound healing. In this phase, keratinocytes...
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A bone growthfactor is a growthfactor that stimulates the growth of bone tissue. Known bone growthfactors include insulin-like growthfactor-1 (IGF-1)...
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induce the expression of growthfactors, such as amphiregulin, epidermal growthfactor (EGF), IGF-1, and fibroblast growthfactor (FGF), which in turn have...