Sprifermin information

Sprifermin
Clinical data
Other names	AS-902330; rhFGF18; L-Methionyl(human fibroblast growth factor 18 (FGF-18, zFGF5)-(1-169)-peptide)
Identifiers
CAS Number	890058-52-3;
UNII	UEJ4E476ZP;
Chemical and physical data
Formula	C876H1396N258O256S6
Molar mass	19830.71 g·mol−1
3D model (JSmol)	Interactive image;
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Sprifermin (INN) (developmental code name AS-902330),^[1] is a recombinant human fibroblast growth factor 18 (rhFGF18) analog,^[2] which is under development by TrialSpark for the treatment of osteoarthritis.^[3] FGF18 and sprifermin act via the Fibroblast Growth Factor Receptor (FGFR) family, with preferential activity via FGFR3c.^[4]

^ "Inxight Drugs: Sprifermin". National Center for Advancing Translational Sciences.
^ Gigout A, Guehring H, Froemel D, Meurer A, Ladel C, Reker D, et al. (November 2017). "Sprifermin (rhFGF18) enables proliferation of chondrocytes producing a hyaline cartilage matrix". Osteoarthritis and Cartilage. 25 (11): 1858–1867. doi:10.1016/j.joca.2017.08.004. PMID 28823647.
^ "Sprifermin - Merck". Adis Insight. Springer Nature Switzerland AG.
^ Ornitz DM, Itoh N (2015). "The Fibroblast Growth Factor signaling pathway". Wiley Interdisciplinary Reviews. Developmental Biology. 4 (3): 215–266. doi:10.1002/wdev.176. PMC 4393358. PMID 25772309.

[1] "Inxight Drugs: Sprifermin". National Center for Advancing Translational Sciences.

[2] Gigout A, Guehring H, Froemel D, Meurer A, Ladel C, Reker D, et al. (November 2017). "Sprifermin (rhFGF18) enables proliferation of chondrocytes producing a hyaline cartilage matrix". Osteoarthritis and Cartilage. 25 (11): 1858–1867. doi:10.1016/j.joca.2017.08.004. PMID 28823647.

[AdisInsight-3] "Sprifermin - Merck". Adis Insight. Springer Nature Switzerland AG.

[4] Ornitz DM, Itoh N (2015). "The Fibroblast Growth Factor signaling pathway". Wiley Interdisciplinary Reviews. Developmental Biology. 4 (3): 215–266. doi:10.1002/wdev.176. PMC 4393358. PMID 25772309.

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