Fibroblast growth factor receptor 1 information

FGFR1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1AGW, 1CVS, 1EVT, 1FGI, 1FGK, 1FQ9, 1XR0, 2CR3, 2FGI, 3C4F, 3DPK, 3GQI, 3GQL, 3JS2, 3KRJ, 3KRL, 3KXX, 3KY2, 3RHX, 3TT0, 4F63, 4F64, 4F65, 4NK9, 4NKA, 4NKS, 4RWI, 4RWJ, 4RWK, 4RWL, 4UWY, 4WUN, 5AM6, 5AM7, 4ZSA, 5A4C, 4UWB, 4UWC, 5A46, 5FLF, 5EW8, 5B7V
Identifiers
Aliases	FGFR1, BFGFR, CD331, CEK, FGFBR, FGFR-1, FLG, FLT-2, FLT2, HBGFR, HH2, HRTFDS, KAL2, N-SAM, OGD, bFGF-R-1, ECCL, fibroblast growth factor receptor 1
External IDs	OMIM: 136350 MGI: 95522 HomoloGene: 69065 GeneCards: FGFR1
Gene location (Human)
Chr.	Chromosome 8 (human)
End	38,468,834 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	26,065,734 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; Achilles tendon; ; right coronary artery; ; left uterine tube; ; body of pancreas; ; ascending aorta; ; popliteal artery; ; gallbladder; ; gastric mucosa; ; saphenous vein;
	Top expressed in
	molar; ; body of femur; ; pontine nuclei; ; lip; ; ankle; ; calvaria; ; median eminence; ; ankle joint; ; cerebellar cortex; ; dermis;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	kinase activity; transmembrane receptor protein tyrosine kinase activity; ATP binding; protein kinase activity; transferase activity; protein homodimerization activity; protein binding; nucleotide binding; identical protein binding; fibroblast growth factor binding; fibroblast growth factor-activated receptor activity; heparin binding; 1-phosphatidylinositol-3-kinase activity; protein tyrosine kinase activity; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; receptor-receptor interaction; receptor tyrosine kinase; transmembrane signaling receptor activity; SH2 domain binding;
Cellular component	cytoplasm; cytosol; membrane; extracellular region; nucleus; receptor complex; integral component of plasma membrane; cytoplasmic vesicle; plasma membrane; integral component of membrane; nucleolus;
Biological process	skeletal system development; ureteric bud development; fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development; positive regulation of endothelial cell chemotaxis to fibroblast growth factor; positive regulation of MAP kinase activity; positive regulation of phospholipase C activity; regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling; positive regulation of cardiac muscle cell proliferation; mesenchymal cell differentiation; positive regulation of mesenchymal cell proliferation; angiogenesis; orbitofrontal cortex development; positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway; branching involved in salivary gland morphogenesis; regulation of transcription, DNA-templated; blood vessel morphogenesis; regulation of extrinsic apoptotic signaling pathway in absence of ligand; lung development; in utero embryonic development; cell maturation; negative regulation of gene expression; transcription, DNA-templated; positive regulation of cell cycle; embryonic limb morphogenesis; positive regulation of neuron differentiation; protein autophosphorylation; auditory receptor cell development; positive regulation of MAPK cascade; paraxial mesoderm development; chondrocyte differentiation; organ induction; phosphorylation; ventricular zone neuroblast division; skeletal system morphogenesis; neuron migration; outer ear morphogenesis; negative regulation of transcription by RNA polymerase II; middle ear morphogenesis; regulation of gene expression; phosphatidylinositol-mediated signaling; midbrain development; chordate embryonic development; sensory perception of sound; salivary gland morphogenesis; generation of neurons; MAPK cascade; regulation of lateral mesodermal cell fate specification; positive regulation of phospholipase activity; brain development; regulation of cell population proliferation; inner ear morphogenesis; positive regulation of neuron projection development; regulation of cell differentiation; positive regulation of phosphatidylinositol 3-kinase signaling; peptidyl-tyrosine phosphorylation; lung-associated mesenchyme development; cell migration; phosphatidylinositol-3-phosphate biosynthetic process; phosphatidylinositol phosphate biosynthetic process; protein phosphorylation; fibroblast growth factor receptor signaling pathway; positive regulation of cell population proliferation; positive regulation of parathyroid hormone secretion; negative regulation of fibroblast growth factor production; vitamin D3 metabolic process; regulation of phosphorus metabolic process; positive regulation of mitotic cell cycle DNA replication; positive regulation of protein kinase B signaling; regulation of phosphate transport; positive regulation of blood vessel endothelial cell migration; positive regulation of vascular endothelial cell proliferation; ear development; negative regulation of signal transduction; cell differentiation; negative regulation of apoptotic process; positive regulation of ERK1 and ERK2 cascade; transmembrane receptor protein tyrosine kinase signaling pathway; nervous system development; positive regulation of cell differentiation;
	Sources:Amigo / QuickGO
Orthologs
	2260
	14182
	ENSG00000077782
	ENSMUSG00000031565
	P11362
	P16092
NM_001174063; NM_001174064; NM_001174065; NM_001174066; NM_001174067;
	NM_015850; NM_023105; NM_023106; NM_023107; NM_023108; NM_023109; NM_023110; NM_023111; NM_032191; NM_001354367; NM_001354368; NM_001354369; NM_001354370
	NM_001079908; NM_001079909; NM_010206
NP_001167534; NP_001167535; NP_001167536; NP_001167537; NP_001167538;
	NP_056934; NP_075593; NP_075594; NP_075598; NP_001341296; NP_001341297; NP_001341298; NP_001341299
	NP_001073377; NP_001073378; NP_034336
	Wikidata
View/Edit Human	View/Edit Mouse

Fibroblast growth factor receptor 1 (FGFR1), also known as basic fibroblast growth factor receptor 1, fms-related tyrosine kinase-2 / Pfeiffer syndrome, and CD331, is a receptor tyrosine kinase whose ligands are specific members of the fibroblast growth factor family. FGFR1 has been shown to be associated with Pfeiffer syndrome,^[5] and clonal eosinophilias.^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000077782 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000031565 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Itoh N, Terachi T, Ohta M, Seo MK (June 1990). "The complete amino acid sequence of the shorter form of human basic fibroblast growth factor receptor deduced from its cDNA". Biochemical and Biophysical Research Communications. 169 (2): 680–685. doi:10.1016/0006-291X(90)90384-Y. PMID 2162671.
^ Cite error: The named reference Gotlib_2015 was invoked but never defined (see the help page).

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000077782 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000031565 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[Itoh_1990-5] Itoh N, Terachi T, Ohta M, Seo MK (June 1990). "The complete amino acid sequence of the shorter form of human basic fibroblast growth factor receptor deduced from its cDNA". Biochemical and Biophysical Research Communications. 169 (2): 680–685. doi:10.1016/0006-291X(90)90384-Y. PMID 2162671.

[Gotlib_2015-6] Cite error: The named reference Gotlib_2015 was invoked but never defined (see the help page).

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