The keratinocyte growth factor (KGF), also known as FGF7, is a growth factor present in the epithelialization-phase of wound healing. In this phase, keratinocytes are covering the wound, forming the epithelium.
KGF is a small signaling molecule that binds to fibroblast growth factor receptor 2b (FGFR2b).[1] For signalling to occur, a dimer is required between two FGF:FGFR complexes that is linked together by a molecule of heparin.
There are 23 known FGFs, and 4 FGF receptors. FGF:FGFR binding is complex and regulated by a variety of mechanisms in a tissue specific manner.
FGF10 is also known as "keratinocyte growth factor 2".[2]
^Rotolo S, Ceccarelli S, Romano F, Frati L, Marchese C, Angeloni A (2008). Maas S (ed.). "Silencing of Keratinocyte Growth Factor Receptor Restores 5-Fluorouracil and Tamoxifen Efficacy on Responsive Cancer Cells". PLOS ONE. 3 (6): e2528. Bibcode:2008PLoSO...3.2528R. doi:10.1371/journal.pone.0002528. PMC 2424182. PMID 18575591.
^"iHOP - Information Hyperlinked over Proteins [ FGF10 ]". Archived from the original on 2012-02-14.
and 25 Related for: Keratinocyte growth factor information
The keratinocytegrowthfactor (KGF), also known as FGF7, is a growthfactor present in the epithelialization-phase of wound healing. In this phase, keratinocytes...
capable of activating all 7 different FGFRs. In contrast, FGF7 (keratinocytegrowthfactor, KGF) binds only to FGFR2b (KGFR). The signalling complex at the...
Transforming growthfactor ([attribution needed], or TGF) is used to describe two classes of polypeptide growthfactors, TGFα and TGFβ. The name "Transforming...
Keratinocytegrowthfactor is a protein that in humans is encoded by the FGF7 gene. The protein encoded by this gene is a member of the fibroblast growth...
mutant keratinocytes deviated from the normal epidermal cell identity. Vitamin A and its analogues. Epidermal growthfactor. Transforming growthfactor alpha...
family member is a high-affinity receptor for acidic, basic and/or keratinocytegrowthfactor, depending on the isoform. FGFR2 has important roles in embryonic...
Hepatocyte growthfactor (HGF) or scatter factor (SF) is a paracrine cellular growth, motility and morphogenic factor. It is secreted by mesenchymal cells...
"Fibroblast growthfactor receptor 4 is a high affinity receptor for both acidic and basic fibroblast growthfactor but not for keratinocytegrowthfactor". J...
insulin-like growthfactor receptors, which leads to proliferation of keratinocytes, fibroblasts and other cells in the skin. Activation of other growthfactor receptors...
of recombinant human fibroblast growthfactor (FGF)-10 reveals functional similarities with keratinocytegrowthfactor (FGF-7)". The Journal of Biological...
in Wiktionary, the free dictionary. KGF or kgf may refer to: Keratinocytegrowthfactor King George's Fields, UK, recreation grounds Kolar Gold Fields...
basal cells stimulate their own division. Keratinocytegrowthfactor (KGF or FGF7) is a paracrine growthfactor produced by the underlying dermal fibroblasts...
at the wound edges. Growthfactors, stimulated by integrins and MMPs, cause cells to proliferate at the wound edges. Keratinocytes themselves also produce...
concentrations of growthfactors such as Platelet-derived growthfactor and KeratinocyteGrowthFactor are lower. Since growthfactors (GFs) are imperative...
found to be systemically absorbed. Palifermin is a human KGF (keratinocytegrowthfactor) that has shown to enhance epithelial cell proliferation, differentiation...
signaling from FGF7 (keratinocytegrowthfactor) produced by the dermis below the basal cells. In mice, over-expression of these factors leads to an overproduction...
mutations that causes the syndrome in 98% of the patients. KGFR, keratinocytegrowthfactor receptor, is an isoform active in the metaphysis and interphalangeal...
amphiregulin too. Moreover, Tregs that express amphiregulin, along with keratinocytegrowthfactor (KGF), CD39 and CD73, act on parenchymal cells to promote tissue...
(June 2003). "P63 alpha mutations lead to aberrant splicing of keratinocytegrowthfactor receptor in the Hay-Wells syndrome". The Journal of Biological...
(June 2003). "P63 alpha mutations lead to aberrant splicing of keratinocytegrowthfactor receptor in the Hay-Wells syndrome". The Journal of Biological...
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