Acanthosis nigricans is a medical sign characterised by brown-to-black, poorly defined, velvety hyperpigmentation of the skin.[1] It is usually found in body folds,[2] such as the posterior and lateral folds of the neck, the armpits, groin, navel, forehead and other areas.[1]
It is associated with endocrine dysfunction, especially insulin resistance and hyperinsulinaemia, as seen in diabetes mellitus. This activates the insulin-like growth factor receptors, which leads to proliferation of keratinocytes, fibroblasts and other cells in the skin. Activation of other growth factor receptors such as fibroblast growth factor receptors or epidermal growth factor receptor can also be responsible.[3]
^ abJames, William D.; Elston, Dirk; Treat, James R.; Rosenbach, Misha A.; Neuhaus, Isaac (2020). "24. Endocrine diseases". Andrews' Diseases of the Skin: Clinical Dermatology (13th ed.). Elsevier. pp. 502–504. ISBN 978-0-323-54753-6.
^"acanthosis nigricans" at Dorland's Medical Dictionary
^Cite error: The named reference HIGGINS2008 was invoked but never defined (see the help page).
and 21 Related for: Acanthosis nigricans information
Acanthosisnigricans is a medical sign characterised by brown-to-black, poorly defined, velvety hyperpigmentation of the skin. It is usually found in body...
(stratum basale and stratum spinosum). Acanthosisnigricans is a black, poorly defined, velvety hyperpigmented acanthosis, usually observed in the back of neck...
Severe achondroplasia with developmental delay and acanthosisnigricans (SADDAN) is a very rare genetic disorder. This disorder is one that affects bone...
endocrine system in many ways. Acanthosisnigricans associated with malignancy (acanthosisnigricans type I) Acanthosisnigricans associated with obesity, insulin-resistant...
Nigricans, a Latin word meaning black, may refer to : Acanthosisnigricans, a brown to black, poorly defined, velvety hyperpigmentation of the skin Ulmus...
(craniosynostosis) during development and a skin condition called acanthosisnigricans. Some of the signs and symptoms of Crouzonodermoskeletal syndrome...
hypochondroplasia and SADDAN (severe achondroplasia with developmental delay and acanthosisnigricans), a rare disorder of bone growth characterized by skeletal, brain...
together with other signs of internal cancer, especially malignant acanthosisnigricans, tripe palms, Leser–Trélat sign, and hypertrichosis lanuginosa acquisita...
polycystic ovarian syndrome in women and erectile dysfunction in men; and acanthosisnigricans. Neck circumference has been used as a surrogate simple and reliable...
following diseases manifest by means of mucocutaneous dysfunction: acanthosisnigricans, dermatomyositis, Leser-Trélat sign, necrolytic migratory erythema...
is a byproduct of ACTH synthesis from proopiomelanocortin (POMC). Acanthosisnigricans—hyperpigmentation of intertriginous areas associated with insulin...
anomalies-porokeratosis syndrome Crouzon syndrome Crouzon syndrome-acanthosisnigricans syndrome DeSanto-Shinawi syndrome due to WAC point mutation Ehlers-Danlos...
Contents: Top A B C D E F G H I J K L M N O P R S T U V X References Acanthosisnigricans A brown to black, poorly defined, velvety hyperpigmentation of the...
signs that may be noted at the same time include most frequently acanthosisnigricans (AN), and less commonly finger clubbing and Leser-Trélat sign. The...
common. Other conditions associated with this condition include acanthosisnigricans, fatty liver, hypertriglyceridemia and polycystic ovary syndrome...
become clogged, making hair fall out and preventing further growth. AcanthosisNigricans (AN): A skin condition where dark, thick and "velvety" patches can...
hyperplasia of the skin, frequently of the axilla and groin, known as acanthosisnigricans, is associated with intra-abdominal cancers such as gastric cancer...
association of ectodermal dysplasia (hypotrichosis and hypohidrosis) with acanthosisnigricans. Other clinical features may include palmoplantar hyperkeratosis...
99 mg/dL Known vascular disease Markers of insulin resistance (PCOS, acanthosisnigricans) The United States Preventative Services Task Force (USPSTF) recommends...
Global Information