TNFSF9 information

TNFSF9
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2X29
Identifiers
Aliases	TNFSF9, 4-1BB-L, CD137L, TNLG5A, tumor necrosis factor superfamily member 9, TNF superfamily member 9
External IDs	OMIM: 606182; MGI: 1101058; HomoloGene: 55782; GeneCards: TNFSF9; OMA:TNFSF9 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	6,535,924 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	57,414,757 bp
RNA expression pattern
	Top expressed in
	internal globus pallidus; ; vagina; ; Brodmann area 9; ; upper lobe of left lung; ; prefrontal cortex; ; cerebellar hemisphere; ; cingulate gyrus; ; hypothalamus; ; amniotic fluid; ; amygdala;
	Top expressed in
	cumulus cell; ; humerus; ; medial ganglionic eminence; ; Meckel's cartilage; ; lens; ; sphenoid bone; ; primitive streak; ; endocardial cushion; ; abdominal wall; ; uterus;
	More reference expression data
	n/a
Gene ontology
Molecular function	tumor necrosis factor receptor binding; cytokine activity; signaling receptor binding; tumor necrosis factor receptor superfamily binding;
Cellular component	integral component of membrane; membrane; extracellular space; plasma membrane;
Biological process	cell-cell signaling; cell population proliferation; immune response; signal transduction; apoptotic process; positive regulation of activated T cell proliferation; positive regulation of cytotoxic T cell differentiation; tumor necrosis factor-mediated signaling pathway; regulation of signaling receptor activity; regulation of T cell proliferation; regulation of apoptotic process;
	Sources:Amigo / QuickGO
Orthologs
	8744
	21950
	ENSG00000125657
	ENSMUSG00000035678
	P41273
	P41274
	NM_003811
	NM_009404
	NP_003802
	NP_033430
	Wikidata
View/Edit Human	View/Edit Mouse

Tumor necrosis factor ligand superfamily member 9 also known as 4-1BB ligand or 4-1BBL or CD137L is a protein that in humans is encoded by the TNFSF9 gene.^[5]

4-1BBL is a type 2 transmembrane glycoprotein receptor that is found on APCs (antigen presenting cells) and binds to 4-1BB (also known as CD137). The 4-1BB/4-1BBL complex belongs to the TNFR:TNF superfamily,^[6] which is expressed on activated T Lymphocytes.^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000125657 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000035678 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Singh R, Kim YH, Lee SJ, Eom HS, Choi BK (Feb 2024). "4-1BB immunotherapy: advances and hurdles". Experimental & Molecular Medicine volume. 56 (1): 32–39. doi:10.1038/s12276-023-01136-4. PMC 10834507. PMID 38172595.
^ Cheuk AT, Mufti GJ, Guinn BA (March 2004). "Role of 4-1BB:4-1BB ligand in cancer immunotherapy". Cancer Gene Therapy. 11 (3): 215–26. doi:10.1038/sj.cgt.7700670. PMID 14671675. S2CID 11429744.
^ Lotze M (2001). Dendritic Cells. Boston: Academic Press. ISBN 0-12-455851-8.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000125657 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000035678 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[:3-5] Singh R, Kim YH, Lee SJ, Eom HS, Choi BK (Feb 2024). "4-1BB immunotherapy: advances and hurdles". Experimental & Molecular Medicine volume. 56 (1): 32–39. doi:10.1038/s12276-023-01136-4. PMC 10834507. PMID 38172595.

[:0-6] Cheuk AT, Mufti GJ, Guinn BA (March 2004). "Role of 4-1BB:4-1BB ligand in cancer immunotherapy". Cancer Gene Therapy. 11 (3): 215–26. doi:10.1038/sj.cgt.7700670. PMID 14671675. S2CID 11429744.

[7] Lotze M (2001). Dendritic Cells. Boston: Academic Press. ISBN 0-12-455851-8.

TNFSF9 information

and 27 Related for: TNFSF9 information

TNFSF9

Tumor necrosis factor

Haematopoiesis

Cytokine

Interferon

Inflammatory cytokine

Interferon type I

Transfer factor

Interleukin 6

Interleukin 1 beta

CXCL10

CCL2

Lymphokine

Chemokine

Myokine

Tumor necrosis factor superfamily

Macrophage inflammatory protein

Interleukin 12

Interleukin 23

Interleukin 23 subunit alpha

CXCL1

Interferon gamma

Interleukin 4

Interleukin 2

Growth factor

Interleukin 17

Interleukin