CXCL10 information

CXCL10
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1O80, 1LV9, 1O7Y, 1O7Z
Identifiers
Aliases	CXCL10, C7, IFI10, INP10, IP-10, SCYB10, crg-2, gIP-10, mob-1, C-X-C motif chemokine ligand 10, C-X-C motif chemokine 10
External IDs	OMIM: 147310 MGI: 1352450 HomoloGene: 1203 GeneCards: CXCL10
Gene location (Human)
Chr.	Chromosome 4 (human)
End	76,023,497 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	92,496,748 bp
RNA expression pattern
	Top expressed in
	appendix; ; lymph node; ; rectum; ; monocyte; ; smooth muscle tissue; ; palpebral conjunctiva; ; germinal epithelium; ; pancreatic ductal cell; ; gallbladder; ; periodontal fiber;
	Top expressed in
	thymus; ; spleen; ; spermatocyte; ; optic nerve; ; subcutaneous adipose tissue; ; jejunum; ; liver; ; duodenum; ; kidney; ; bone marrow;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	cytokine activity; heparin binding; CXCR3 chemokine receptor binding; chemokine activity; protein binding; cAMP-dependent protein kinase regulator activity; signaling receptor binding; chemoattractant activity;
Cellular component	extracellular region; external side of plasma membrane; extracellular space; intracellular anatomical structure;
Biological process	regulation of endothelial tube morphogenesis; negative regulation of myoblast differentiation; cellular response to heat; response to vitamin D; positive regulation of cell migration; T cell chemotaxis; chemokine-mediated signaling pathway; cell-cell signaling; response to virus; muscle organ development; positive regulation of monocyte chemotaxis; positive regulation of release of sequestered calcium ion into cytosol; endothelial cell activation; positive regulation of cAMP-mediated signaling; regulation of T cell chemotaxis; blood circulation; chemotaxis; positive regulation of leukocyte chemotaxis; cell surface receptor signaling pathway; response to lipopolysaccharide; negative regulation of myoblast fusion; defense response to virus; regulation of cell population proliferation; immune response; positive regulation of cell population proliferation; response to auditory stimulus; negative regulation of angiogenesis; response to cold; cellular response to lipopolysaccharide; response to gamma radiation; positive regulation of T cell migration; signal transduction; positive regulation of transcription by RNA polymerase II; regulation of protein kinase activity; defense response; inflammatory response; antimicrobial humoral immune response mediated by antimicrobial peptide; regulation of signaling receptor activity; G protein-coupled receptor signaling pathway; cytokine-mediated signaling pathway; adenylate cyclase-activating G protein-coupled receptor signaling pathway; response to bacterium; neutrophil chemotaxis; leukocyte chemotaxis; positive chemotaxis; regulation of apoptotic process;
	Sources:Amigo / QuickGO
Orthologs
	3627
	15945
	ENSG00000169245
	ENSMUSG00000034855
	P02778
	P17515
	NM_001565
	NM_021274
	NP_001556
	NP_067249
	Wikidata
View/Edit Human	View/Edit Mouse

C-X-C motif chemokine ligand 10 (CXCL10) also known as Interferon gamma-induced protein 10 (IP-10) or small-inducible cytokine B10 is an 8.7 kDa protein that in humans is encoded by the CXCL10 gene.^[5]^[6] C-X-C motif chemokine 10 is a small cytokine belonging to the CXC chemokine family.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000169245 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000034855 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Cite error: The named reference pmid3925348 was invoked but never defined (see the help page).
^ Luster AD, Jhanwar SC, Chaganti RS, Kersey JH, Ravetch JV (May 1987). "Interferon-inducible gene maps to a chromosomal band associated with a (4;11) translocation in acute leukemia cells". Proceedings of the National Academy of Sciences of the United States of America. 84 (9): 2868–71. Bibcode:1987PNAS...84.2868L. doi:10.1073/pnas.84.9.2868. PMC 304761. PMID 2437586.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000169245 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000034855 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid3925348-5] Cite error: The named reference pmid3925348 was invoked but never defined (see the help page).

[pmid2437586-6] Luster AD, Jhanwar SC, Chaganti RS, Kersey JH, Ravetch JV (May 1987). "Interferon-inducible gene maps to a chromosomal band associated with a (4;11) translocation in acute leukemia cells". Proceedings of the National Academy of Sciences of the United States of America. 84 (9): 2868–71. Bibcode:1987PNAS...84.2868L. doi:10.1073/pnas.84.9.2868. PMC 304761. PMID 2437586.

CXCL10 information

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