Lymphokines are a subset of cytokines that are produced by a type of immune cell known as a lymphocyte.[1] They are protein mediators typically produced by T cells to direct the immune system response by signaling between its cells. Lymphokines have many roles, including the attraction of other immune cells, including macrophages and other lymphocytes, to an infected site and their subsequent activation to prepare them to mount an immune response. Circulating lymphocytes can detect a very small concentration of lymphokine and then move up the concentration gradient towards where the immune response is required. Lymphokines aid B cells to produce antibodies.
Important lymphokines secreted by the T helper cell include:[2]
Interleukin 2
Interleukin 3
Interleukin 4
Interleukin 5
Interleukin 6
Granulocyte-macrophage colony-stimulating factor
Interferon-gamma
^Julius M. Cruse; Robert Edwin Lewis (20 April 2009). Illustrated dictionary of immunology. CRC Press. pp. 208–. ISBN 978-0-8493-7987-1. Retrieved 24 April 2011.
Lymphokines are a subset of cytokines that are produced by a type of immune cell known as a lymphocyte. They are protein mediators typically produced...
(TSF, etc.). This decision was taken during the Second International Lymphokine Workshop in Switzerland (27–31 May 1979 in Ermatingen). The term interleukin...
immunomodulating agents. Cytokines include chemokines, interferons, interleukins, lymphokines, and tumour necrosis factors, but generally not hormones or growth factors...
alternative pathogenesis: cell-mediated immunity. Their data suggests that lymphokines, such as macrophage-inhibiting factor (MIF), leads to sequestration of...
S2CID 4447611. Howard M, Paul WE (1982). "Interleukins for B lymphocytes". Lymphokine Research. 1 (1): 1–4. PMID 6985399. Yokota T, Otsuka T, Mosmann T, Banchereau...
of MHC and antigen attracts a matching helper T cell, which releases lymphokines and activates the B cell. As the activated B cell then begins to divide...
circumstances induces the transcription of interleukin-2. The drug also inhibits lymphokine production and interleukin release, leading to a reduced function of effector...
was changed in 1978 to IL-2 (interleukin-2) by the Second International Lymphokine Conference (which was held in Interlaken, Switzerland). Although earlier...
is a protein that in humans is encoded by the FBRS gene. Fibrosin is a lymphokine secreted by activated lymphocytes that induces fibroblast proliferation...
Cell types that can be used in this way are natural killer (NK) cells, lymphokine-activated killer cells, cytotoxic T cells, and dendritic cells. Finally...
cell-derived glucosteroid response-modifying factor (GRMFT): a unique lymphokine made by normal T lymphocytes and a T cell hybridoma". Journal of Immunology...
some evidence supports the hypothesis that this is a consequence of Th1 lymphokine prevalence. Tests of delayed cutaneous hypersensitivity have been used...
cell-mediated immunity, primarily delayed hypersensitivity and the production of lymphokines, as well as binding to the antigens themselves. They have a molecular...
team based in Los Angeles, California Lao kip, ISO 4217 currency code Lymphokine-activated killer cell Aklavik/Freddie Carmichael Airport, Northwest Territories...
Czerkinsky developed an ELISA spot assay that quantified the secretion of a lymphokine by T cells. In the same year, dual-color ELISpot was combined with computer...
synthetic hormones, immunobiologicals (monoclonal antibodies, interleukins, lymphokines), and anticancer agents. Although many simpler proteins can be produced...
presentation is a fever (release of endogenous pyrogens often related to lymphokines or tissue pyrogens), but the overall picture will often include several...
towards a TH1 or TH2 response. Each type has distinctive patterns of lymphokine and chemokine expression, specific types of immunoglobulins, patterns...
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