Chemical compound
Serlopitant Routes of administration By mouth ATC code
3-[(3aR ,4R ,5S ,7aS )-5-{(1R )-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy}-4-(4-fluorophenyl)octahydro-2H -isoindol-2-yl]cyclopent-2-en-1-one
CAS Number PubChem CID ChemSpider UNII KEGG ChEMBL CompTox Dashboard (EPA ) DTXSID701006599 Formula C 29 H 28 F 7 N O 2 Molar mass 555.537 g·mol−1 3D model (JSmol)
C[C@H](C1=CC(=CC(=C1)C(F)(F)F)C(F)(F)F)O[C@H]2CC[C@@H]3CN(C[C@H]3[C@@H]2C4=CC=C(C=C4)F)C5=CC(=O)CC5
InChI=1S/C29H28F7NO2/c1-16(19-10-20(28(31,32)33)12-21(11-19)29(34,35)36)39-26-9-4-18-14-37(23-7-8-24(38)13-23)15-25(18)27(26)17-2-5-22(30)6-3-17/h2-3,5-6,10-13,16,18,25-27H,4,7-9,14-15H2,1H3/t16-,18-,25-,26+,27+/m1/s1
Key:FLNYCRJBCNNHRH-OIYLJQICSA-N
Serlopitant (INN,[1] codenamed VPD-737 ) is a drug which acts as an NK1 receptor antagonist. It was assessed in clinical trials for the treatment of urinary incontinence and overactive bladder, but while it was superior to placebo it provided no advantage over existing approved drugs, and was not approved for further development for this indication.[2] [3] Serlopitant is now undergoing clinical trials for the treatment of chronic pruritus (itch)[4]
^ "International Nonproprietary Names for Pharmaceutical Substances (INN). Recommended International Nonproprietary Names: List 62" (PDF) . World Health Organization. 2009. pp. 261–2. Retrieved 17 November 2016 .
^ Frenkl TL, Zhu H, Reiss T, Seltzer O, Rosenberg E, Green S (August 2010). "A multicenter, double-blind, randomized, placebo controlled trial of a neurokinin-1 receptor antagonist for overactive bladder". The Journal of Urology . 184 (2): 616–22. doi:10.1016/j.juro.2010.03.147. PMID 20639026.
^ Payton S (August 2010). "Urinary incontinence: Neurokinin receptor antagonist inferior to tolterodine for OAB". Nature Reviews. Urology . 7 (8): 418. doi:10.1038/nrurol.2010.105 . PMID 20726068. S2CID 33202979.
^ "For Irritating Itch, a Promising Option Under Scrutiny".
Last Update: 2023-04-03T09:36:33Z
Serlopitant (INN, codenamed VPD-737) is a drug which acts as an NK1 receptor antagonist. It was assessed in clinical trials for the treatment of urinary...
Word Count : 186
Last Update: 2023-10-06T03:37:05Z
NKP-608 Nolpitantium besilate Orvepitant Rolapitant RP-67580 SDZ NKT 343 Serlopitant T-2328 Telmapitant Tradipitant Vestipitant Vofopitant NK2 Agonists: Neurokinin...
Word Count : 1737
Last Update: 2024-03-17T19:07:38Z
NKP-608 Nolpitantium besilate Orvepitant Rolapitant RP-67580 SDZ NKT 343 Serlopitant T-2328 Telmapitant Tradipitant Vestipitant Vofopitant NK2 Agonists: Neurokinin...
Word Count : 5337
Last Update: 2023-12-20T19:49:29Z
NKP-608 Nolpitantium besilate Orvepitant Rolapitant RP-67580 SDZ NKT 343 Serlopitant T-2328 Telmapitant Tradipitant Vestipitant Vofopitant NK2 Agonists: Neurokinin...
Word Count : 248
Last Update: 2024-03-30T06:32:48Z
NKP-608 Nolpitantium besilate Orvepitant Rolapitant RP-67580 SDZ NKT 343 Serlopitant T-2328 Telmapitant Tradipitant Vestipitant Vofopitant NK2 Agonists: Neurokinin...
Word Count : 1260
Last Update: 2024-06-03T13:48:33Z
NKP-608 Nolpitantium besilate Orvepitant Rolapitant RP-67580 SDZ NKT 343 Serlopitant T-2328 Telmapitant Tradipitant Vestipitant Vofopitant NK2 Agonists: Neurokinin...
Word Count : 2210
Last Update: 2024-01-04T19:10:30Z
NKP-608 Nolpitantium besilate Orvepitant Rolapitant RP-67580 SDZ NKT 343 Serlopitant T-2328 Telmapitant Tradipitant Vestipitant Vofopitant NK2 Agonists: Neurokinin...
Word Count : 223
Last Update: 2023-12-03T15:12:09Z
NKP-608 Nolpitantium besilate Orvepitant Rolapitant RP-67580 SDZ NKT 343 Serlopitant T-2328 Telmapitant Tradipitant Vestipitant Vofopitant NK2 Agonists: Neurokinin...
Word Count : 491
Last Update: 2023-12-05T03:23:30Z
NKP-608 Nolpitantium besilate Orvepitant Rolapitant RP-67580 SDZ NKT 343 Serlopitant T-2328 Telmapitant Tradipitant Vestipitant Vofopitant NK2 Agonists: Neurokinin...
Word Count : 3270
Last Update: 2024-04-29T04:15:33Z
NKP-608 Nolpitantium besilate Orvepitant Rolapitant RP-67580 SDZ NKT 343 Serlopitant T-2328 Telmapitant Tradipitant Vestipitant Vofopitant NK2 Agonists: Neurokinin...
Word Count : 2396
Last Update: 2022-08-21T16:08:12Z
NKP-608 Nolpitantium besilate Orvepitant Rolapitant RP-67580 SDZ NKT 343 Serlopitant T-2328 Telmapitant Tradipitant Vestipitant Vofopitant NK2 Agonists: Neurokinin...
Word Count : 240
Last Update: 2024-01-05T23:33:06Z
NKP-608 Nolpitantium besilate Orvepitant Rolapitant RP-67580 SDZ NKT 343 Serlopitant T-2328 Telmapitant Tradipitant Vestipitant Vofopitant NK2 Agonists: Neurokinin...
Word Count : 236
Last Update: 2023-10-01T01:29:59Z
NKP-608 Nolpitantium besilate Orvepitant Rolapitant RP-67580 SDZ NKT 343 Serlopitant T-2328 Telmapitant Tradipitant Vestipitant Vofopitant NK2 Agonists: Neurokinin...
Word Count : 1716
Last Update: 2024-03-14T07:12:16Z
NKP-608 Nolpitantium besilate Orvepitant Rolapitant RP-67580 SDZ NKT 343 Serlopitant T-2328 Telmapitant Tradipitant Vestipitant Vofopitant NK2 Agonists: Neurokinin...
Word Count : 868
Last Update: 2022-03-05T22:44:27Z
NKP-608 Nolpitantium besilate Orvepitant Rolapitant RP-67580 SDZ NKT 343 Serlopitant T-2328 Telmapitant Tradipitant Vestipitant Vofopitant NK2 Agonists: Neurokinin...
Word Count : 145
Last Update: 2023-01-23T11:29:15Z
NKP-608 Nolpitantium besilate Orvepitant Rolapitant RP-67580 SDZ NKT 343 Serlopitant T-2328 Telmapitant Tradipitant Vestipitant Vofopitant NK2 Agonists: Neurokinin...
Word Count : 273
Last Update: 2023-01-29T12:55:18Z
NKP-608 Nolpitantium besilate Orvepitant Rolapitant RP-67580 SDZ NKT 343 Serlopitant T-2328 Telmapitant Tradipitant Vestipitant Vofopitant NK2 Agonists: Neurokinin...
Word Count : 196
Last Update: 2022-08-27T08:42:55Z
NKP-608 Nolpitantium besilate Orvepitant Rolapitant RP-67580 SDZ NKT 343 Serlopitant T-2328 Telmapitant Tradipitant Vestipitant Vofopitant NK2 Agonists: Neurokinin...
Word Count : 148
Last Update: 2023-12-03T22:17:45Z
NKP-608 Nolpitantium besilate Orvepitant Rolapitant RP-67580 SDZ NKT 343 Serlopitant T-2328 Telmapitant Tradipitant Vestipitant Vofopitant NK2 Agonists: Neurokinin...
Word Count : 116
Last Update: 2024-02-13T05:48:14Z
NKP-608 Nolpitantium besilate Orvepitant Rolapitant RP-67580 SDZ NKT 343 Serlopitant T-2328 Telmapitant Tradipitant Vestipitant Vofopitant NK2 Agonists: Neurokinin...
Word Count : 2873
Last Update: 2023-01-26T02:47:57Z
NKP-608 Nolpitantium besilate Orvepitant Rolapitant RP-67580 SDZ NKT 343 Serlopitant T-2328 Telmapitant Tradipitant Vestipitant Vofopitant NK2 Agonists: Neurokinin...
Word Count : 983
Last Update: 2024-01-30T01:45:55Z
NKP-608 Nolpitantium besilate Orvepitant Rolapitant RP-67580 SDZ NKT 343 Serlopitant T-2328 Telmapitant Tradipitant Vestipitant Vofopitant NK2 Agonists: Neurokinin...
Word Count : 669
Last Update: 2022-03-05T22:44:39Z
NKP-608 Nolpitantium besilate Orvepitant Rolapitant RP-67580 SDZ NKT 343 Serlopitant T-2328 Telmapitant Tradipitant Vestipitant Vofopitant NK2 Agonists: Neurokinin...
Word Count : 177
Last Update: 2022-04-23T10:11:01Z
NKP-608 Nolpitantium besilate Orvepitant Rolapitant RP-67580 SDZ NKT 343 Serlopitant T-2328 Telmapitant Tradipitant Vestipitant Vofopitant NK2 Agonists: Neurokinin...
Word Count : 183
Last Update: 2023-12-03T06:47:57Z
NKP-608 Nolpitantium besilate Orvepitant Rolapitant RP-67580 SDZ NKT 343 Serlopitant T-2328 Telmapitant Tradipitant Vestipitant Vofopitant NK2 Agonists: Neurokinin...
Word Count : 164
Last Update: 2022-09-06T19:23:09Z
NKP-608 Nolpitantium besilate Orvepitant Rolapitant RP-67580 SDZ NKT 343 Serlopitant T-2328 Telmapitant Tradipitant Vestipitant Vofopitant NK2 Agonists: Neurokinin...
Word Count : 226
Last Update: 2023-01-23T11:28:17Z
NKP-608 Nolpitantium besilate Orvepitant Rolapitant RP-67580 SDZ NKT 343 Serlopitant T-2328 Telmapitant Tradipitant Vestipitant Vofopitant NK2 Agonists: Neurokinin...
Word Count : 237