Chemical compound
Pavinetant Other names MLE-4901; AZD-4901; AZD-2624; AZ-12472520 Routes of administration By mouth
3-(methanesulfonamido)-2-phenyl-N -[(1S )-1-phenylpropyl]quinoline-4-carboxamide
CAS Number PubChem CID ChemSpider UNII KEGG ChEBI ChEMBL CompTox Dashboard (EPA ) DTXSID10916204 Formula C 26 H 25 N 3 O 3 S Molar mass 459.56 g·mol−1 3D model (JSmol)
CC[C@@H](C1=CC=CC=C1)NC(=O)C2=C(C(=NC3=CC=CC=C32)C4=CC=CC=C4)NS(=O)(=O)C
InChI=1S/C26H25N3O3S/c1-3-21(18-12-6-4-7-13-18)28-26(30)23-20-16-10-11-17-22(20)27-24(19-14-8-5-9-15-19)25(23)29-33(2,31)32/h4-17,21,29H,3H2,1-2H3,(H,28,30)/t21-/m0/s1
Key:QYTBBBAHNIWFOD-NRFANRHFSA-N
Pavinetant (INN Tooltip International Nonproprietary Name , USAN Tooltip United States Adopted Name ; developmental code names MLE-4901 , AZD-4901 , AZ-12472520 , AZD-2624 ), is a small-molecule, orally active, selective neurokinin-3 (NK3 ) receptor antagonist which was under development by AstraZeneca and Millendo Therapeutics for the treatment of hot flashes and polycystic ovary syndrome (PCOS).[1] [2] [3] It was also under investigation for the treatment of schizophrenia,[2] but development was discontinued for this indication due to lack of effectiveness.[1] [4] In November 2017, development of the medication for hot flashes and PCOS was also terminated after its developer assessed the clinical risks and benefits.[1] [3]
^ a b c "Pavinetant - Millendo Therapeutics - AdisInsight".
^ a b Malherbe P, Ballard TM, Ratni H (2011). "Tachykinin neurokinin 3 receptor antagonists: a patent review (2005 - 2010)". Expert Opin Ther Pat . 21 (5): 637–55. doi:10.1517/13543776.2011.568482. PMID 21417773. S2CID 207473995.
^ a b Sassarini J, Anderson RA (2017). "New pathways in the treatment for menopausal hot flushes". Lancet . 389 (10081): 1775–1777. doi:10.1016/S0140-6736(17)30886-3 . hdl:20.500.11820/f7c16947-678f-40f6-ac53-73343a9d44e7 . PMID 28385351.
^ Litman RE, Smith MA, Desai DG, Simpson T, Sweitzer D, Kanes SJ (2014). "The selective neurokinin 3 antagonist AZD2624 does not improve symptoms or cognition in schizophrenia: a proof-of-principle study". J Clin Psychopharmacol . 34 (2): 199–204. doi:10.1097/JCP.0000000000000071. PMID 24525659. S2CID 33936765.
Last Update: 2024-01-05T23:33:06Z
Pavinetant (INNTooltip International Nonproprietary Name, USANTooltip United States Adopted Name; developmental code names MLE-4901, AZD-4901, AZ-12472520...
Word Count : 236
Last Update: 2023-10-06T03:37:05Z
Nepadutant Saredutant NK3 Agonists: Neurokinin B Senktide Antagonists: Elinzanetant Fezolinetant Osanetant Pavinetant SB-218,795 SB-222,200 Talnetant...
Word Count : 1737
Last Update: 2024-03-30T06:32:48Z
Nepadutant Saredutant NK3 Agonists: Neurokinin B Senktide Antagonists: Elinzanetant Fezolinetant Osanetant Pavinetant SB-218,795 SB-222,200 Talnetant...
Word Count : 1260
Last Update: 2024-03-17T19:07:38Z
Nepadutant Saredutant NK3 Agonists: Neurokinin B Senktide Antagonists: Elinzanetant Fezolinetant Osanetant Pavinetant SB-218,795 SB-222,200 Talnetant...
Word Count : 5337
Last Update: 2023-12-05T03:23:30Z
Nepadutant Saredutant NK3 Agonists: Neurokinin B Senktide Antagonists: Elinzanetant Fezolinetant Osanetant Pavinetant SB-218,795 SB-222,200 Talnetant...
Word Count : 3270
Last Update: 2023-12-20T19:49:29Z
Nepadutant Saredutant NK3 Agonists: Neurokinin B Senktide Antagonists: Elinzanetant Fezolinetant Osanetant Pavinetant SB-218,795 SB-222,200 Talnetant...
Word Count : 248
Last Update: 2024-03-23T23:38:37Z
Nepadutant Saredutant NK3 Agonists: Neurokinin B Senktide Antagonists: Elinzanetant Fezolinetant Osanetant Pavinetant SB-218,795 SB-222,200 Talnetant...
Word Count : 2206
Last Update: 2023-12-03T15:12:09Z
Nepadutant Saredutant NK3 Agonists: Neurokinin B Senktide Antagonists: Elinzanetant Fezolinetant Osanetant Pavinetant SB-218,795 SB-222,200 Talnetant...
Word Count : 491
Last Update: 2023-10-01T01:29:59Z
Nepadutant Saredutant NK3 Agonists: Neurokinin B Senktide Antagonists: Elinzanetant Fezolinetant Osanetant Pavinetant SB-218,795 SB-222,200 Talnetant...
Word Count : 1716
Last Update: 2024-04-29T04:15:33Z
Nepadutant Saredutant NK3 Agonists: Neurokinin B Senktide Antagonists: Elinzanetant Fezolinetant Osanetant Pavinetant SB-218,795 SB-222,200 Talnetant...
Word Count : 2396
Last Update: 2024-01-04T19:10:30Z
Nepadutant Saredutant NK3 Agonists: Neurokinin B Senktide Antagonists: Elinzanetant Fezolinetant Osanetant Pavinetant SB-218,795 SB-222,200 Talnetant...
Word Count : 223
Last Update: 2022-08-21T16:08:12Z
Nepadutant Saredutant NK3 Agonists: Neurokinin B Senktide Antagonists: Elinzanetant Fezolinetant Osanetant Pavinetant SB-218,795 SB-222,200 Talnetant...
Word Count : 240
Last Update: 2024-01-30T01:45:55Z
Nepadutant Saredutant NK3 Agonists: Neurokinin B Senktide Antagonists: Elinzanetant Fezolinetant Osanetant Pavinetant SB-218,795 SB-222,200 Talnetant...
Word Count : 669
Last Update: 2023-01-23T11:29:15Z
Nepadutant Saredutant NK3 Agonists: Neurokinin B Senktide Antagonists: Elinzanetant Fezolinetant Osanetant Pavinetant SB-218,795 SB-222,200 Talnetant...
Word Count : 273
Last Update: 2024-02-13T05:48:14Z
Nepadutant Saredutant NK3 Agonists: Neurokinin B Senktide Antagonists: Elinzanetant Fezolinetant Osanetant Pavinetant SB-218,795 SB-222,200 Talnetant...
Word Count : 2873
Last Update: 2024-03-14T07:12:16Z
Nepadutant Saredutant NK3 Agonists: Neurokinin B Senktide Antagonists: Elinzanetant Fezolinetant Osanetant Pavinetant SB-218,795 SB-222,200 Talnetant...
Word Count : 868
Last Update: 2023-01-26T02:47:57Z
Nepadutant Saredutant NK3 Agonists: Neurokinin B Senktide Antagonists: Elinzanetant Fezolinetant Osanetant Pavinetant SB-218,795 SB-222,200 Talnetant...
Word Count : 983
Last Update: 2024-03-09T23:37:26Z
(BAY-3427080 GSK-1144814, NT-814) Fezolinetant (ESN-364) Osanetant (SR-142,801) Pavinetant (MLE-4901, AZD-4901, AZD-2624) Talnetant (SB-223,412) SB-222,200 – potent...
Word Count : 955
Last Update: 2023-12-03T22:17:45Z
Nepadutant Saredutant NK3 Agonists: Neurokinin B Senktide Antagonists: Elinzanetant Fezolinetant Osanetant Pavinetant SB-218,795 SB-222,200 Talnetant...
Word Count : 116
Last Update: 2023-01-29T12:55:18Z
Nepadutant Saredutant NK3 Agonists: Neurokinin B Senktide Antagonists: Elinzanetant Fezolinetant Osanetant Pavinetant SB-218,795 SB-222,200 Talnetant...
Word Count : 196
Last Update: 2023-04-03T09:36:33Z
Nepadutant Saredutant NK3 Agonists: Neurokinin B Senktide Antagonists: Elinzanetant Fezolinetant Osanetant Pavinetant SB-218,795 SB-222,200 Talnetant...
Word Count : 186
Last Update: 2022-03-05T22:44:27Z
Nepadutant Saredutant NK3 Agonists: Neurokinin B Senktide Antagonists: Elinzanetant Fezolinetant Osanetant Pavinetant SB-218,795 SB-222,200 Talnetant...
Word Count : 145
Last Update: 2022-03-05T22:44:39Z
Nepadutant Saredutant NK3 Agonists: Neurokinin B Senktide Antagonists: Elinzanetant Fezolinetant Osanetant Pavinetant SB-218,795 SB-222,200 Talnetant...
Word Count : 177
Last Update: 2022-09-06T19:23:09Z
Nepadutant Saredutant NK3 Agonists: Neurokinin B Senktide Antagonists: Elinzanetant Fezolinetant Osanetant Pavinetant SB-218,795 SB-222,200 Talnetant...
Word Count : 226
Last Update: 2023-01-23T11:28:17Z
Nepadutant Saredutant NK3 Agonists: Neurokinin B Senktide Antagonists: Elinzanetant Fezolinetant Osanetant Pavinetant SB-218,795 SB-222,200 Talnetant...
Word Count : 237
Last Update: 2024-03-09T23:36:03Z
Nepadutant Saredutant NK3 Agonists: Neurokinin B Senktide Antagonists: Elinzanetant Fezolinetant Osanetant Pavinetant SB-218,795 SB-222,200 Talnetant...
Word Count : 1178
Last Update: 2023-12-22T10:42:13Z
Nepadutant Saredutant NK3 Agonists: Neurokinin B Senktide Antagonists: Elinzanetant Fezolinetant Osanetant Pavinetant SB-218,795 SB-222,200 Talnetant...
Word Count : 371