Chemical compound
Ezlopitant Other names CJ-11,974; (2S ,3S )-2-Diphenylmethyl-3-[(5-isopropyl-2-methoxybenzyl)amino]quinuclidine[1] Routes of administration By mouth ATC code Legal status
Excretion Urine (32%), Feces (51%)
(2S ,3S )-2-Benzhydryl-N -[(5-isopropyl-2-methoxy-phenyl)methyl]quinuclidin-3-amine
CAS Number PubChem CID IUPHAR/BPS ChemSpider UNII ChEMBL CompTox Dashboard (EPA ) DTXSID601318557 Formula C 31 H 38 N 2 O Molar mass 454.658 g·mol−1 3D model (JSmol)
COc1ccc(cc1CN[C@H]2C3CCN(CC3)[C@H]2C(c4ccccc4)c5ccccc5)C(C)C
InChI=1S/C31H38N2O/c1-22(2)26-14-15-28(34-3)27(20-26)21-32-30-25-16-18-33(19-17-25)31(30)29(23-10-6-4-7-11-23)24-12-8-5-9-13-24/h4-15,20,22,25,29-32H,16-19,21H2,1-3H3/t30-,31-/m0/s1
Key:XPNMCDYOYIKVGB-CONSDPRKSA-N
Ezlopitant (INN,[1] code name CJ-11,974 ) is an NK1 receptor antagonist.[2] [3] [4] It has antiemetic and antinociceptive effects.[5] [6] Pfizer was developing ezlopitant for the treatment of irritable bowel syndrome but it appears to have been discontinued.[2]
^ a b "International Nonproprietary Names for Pharmaceutical Substances (INN). Recommended International Nonproprietary Names: List 44" (PDF) . World Health Organization. pp. 194–5. Retrieved 17 November 2016 .
^ a b Evangelista S (October 2001). "Eziopitant. Pfizer". Current Opinion in Investigational Drugs . 2 (10): 1441–3. PMID 11890362.
^ Diemunsch P, Grélot L (September 2000). "Potential of substance P antagonists as antiemetics". Drugs . 60 (3): 533–46. doi:10.2165/00003495-200060030-00002. PMID 11030465. S2CID 25136161.
^ Giardina GA, Gagliardi S, Martinelli M (August 2003). "Antagonists at the neurokinin receptors--recent patent literature". IDrugs: The Investigational Drugs Journal . 6 (8): 758–72. PMID 12917772.
^ Tsuchiya M, Fujiwara Y, Kanai Y, et al. (November 2002). "Anti-emetic activity of the novel nonpeptide tachykinin NK1 receptor antagonist ezlopitant (CJ-11,974) against acute and delayed cisplatin-induced emesis in the ferret". Pharmacology . 66 (3): 144–52. doi:10.1159/000063796. PMID 12372904. S2CID 37936941.
^ Tsuchiya M, Sakakibara A, Yamamoto M (January 2005). "A tachykinin NK1 receptor antagonist attenuates the 4 beta-phorbol-12-myristate-13-acetate-induced nociceptive behaviour in the rat". European Journal of Pharmacology . 507 (1–3): 29–34. doi:10.1016/j.ejphar.2004.11.028. PMID 15659291.
Last Update: 2023-01-23T11:28:17Z
Ezlopitant (INN, code name CJ-11,974) is an NK1 receptor antagonist. It has antiemetic and antinociceptive effects. Pfizer was developing ezlopitant for...
Word Count : 237
Last Update: 2023-10-06T03:37:05Z
Casopitant CI-1021 CP-96345 CP-99994 CP-122721 Dapitant Elinzanetant Ezlopitant Figopitant FK-888 Fosaprepitant Fosnetupitant GR-203040 GW-597599 HSP-117...
Word Count : 1737
Last Update: 2024-06-09T18:40:20Z
Casopitant CI-1021 CP-96345 CP-99994 CP-122721 Dapitant Elinzanetant Ezlopitant Figopitant FK-888 Fosaprepitant Fosnetupitant GR-203040 GW-597599 HSP-117...
Word Count : 5337
Last Update: 2024-06-10T05:53:37Z
Casopitant CI-1021 CP-96345 CP-99994 CP-122721 Dapitant Elinzanetant Ezlopitant Figopitant FK-888 Fosaprepitant Fosnetupitant GR-203040 GW-597599 HSP-117...
Word Count : 1279
Last Update: 2023-12-20T19:49:29Z
Casopitant CI-1021 CP-96345 CP-99994 CP-122721 Dapitant Elinzanetant Ezlopitant Figopitant FK-888 Fosaprepitant Fosnetupitant GR-203040 GW-597599 HSP-117...
Word Count : 248
Last Update: 2024-06-03T13:48:33Z
Casopitant CI-1021 CP-96345 CP-99994 CP-122721 Dapitant Elinzanetant Ezlopitant Figopitant FK-888 Fosaprepitant Fosnetupitant GR-203040 GW-597599 HSP-117...
Word Count : 2210
Last Update: 2024-04-29T04:15:33Z
polypeptide chain. CAS# 133156-06-6 Aprepitant Casopitant Elinzanetant Ezlopitant Fosaprepitant Lanepitant Maropitant Vestipitant L-733,060 L-741,671 L-742...
Word Count : 2396
Last Update: 2022-08-21T16:08:12Z
Casopitant CI-1021 CP-96345 CP-99994 CP-122721 Dapitant Elinzanetant Ezlopitant Figopitant FK-888 Fosaprepitant Fosnetupitant GR-203040 GW-597599 HSP-117...
Word Count : 240
Last Update: 2024-01-04T19:10:30Z
Casopitant CI-1021 CP-96345 CP-99994 CP-122721 Dapitant Elinzanetant Ezlopitant Figopitant FK-888 Fosaprepitant Fosnetupitant GR-203040 GW-597599 HSP-117...
Word Count : 223
Last Update: 2024-01-30T01:45:55Z
Casopitant CI-1021 CP-96345 CP-99994 CP-122721 Dapitant Elinzanetant Ezlopitant Figopitant FK-888 Fosaprepitant Fosnetupitant GR-203040 GW-597599 HSP-117...
Word Count : 669
Last Update: 2023-12-05T03:23:30Z
several other related NK1 receptor antagonists. CJ-11974, also called ezlopitant , was a close analog of CP-96345 that had an isopropyl group on the methoxybenzyl...
Word Count : 3270
Last Update: 2024-01-05T23:33:06Z
Casopitant CI-1021 CP-96345 CP-99994 CP-122721 Dapitant Elinzanetant Ezlopitant Figopitant FK-888 Fosaprepitant Fosnetupitant GR-203040 GW-597599 HSP-117...
Word Count : 236
Last Update: 2024-03-14T07:12:16Z
Casopitant CI-1021 CP-96345 CP-99994 CP-122721 Dapitant Elinzanetant Ezlopitant Figopitant FK-888 Fosaprepitant Fosnetupitant GR-203040 GW-597599 HSP-117...
Word Count : 868
Last Update: 2024-06-25T22:29:42Z
Casopitant CI-1021 CP-96345 CP-99994 CP-122721 Dapitant Elinzanetant Ezlopitant Figopitant FK-888 Fosaprepitant Fosnetupitant GR-203040 GW-597599 HSP-117...
Word Count : 1716
Last Update: 2022-03-05T22:44:27Z
Casopitant CI-1021 CP-96345 CP-99994 CP-122721 Dapitant Elinzanetant Ezlopitant Figopitant FK-888 Fosaprepitant Fosnetupitant GR-203040 GW-597599 HSP-117...
Word Count : 145
Last Update: 2023-01-29T12:55:18Z
Casopitant CI-1021 CP-96345 CP-99994 CP-122721 Dapitant Elinzanetant Ezlopitant Figopitant FK-888 Fosaprepitant Fosnetupitant GR-203040 GW-597599 HSP-117...
Word Count : 196
Last Update: 2024-02-13T05:48:14Z
Casopitant CI-1021 CP-96345 CP-99994 CP-122721 Dapitant Elinzanetant Ezlopitant Figopitant FK-888 Fosaprepitant Fosnetupitant GR-203040 GW-597599 HSP-117...
Word Count : 2873
Last Update: 2023-01-26T02:47:57Z
Casopitant CI-1021 CP-96345 CP-99994 CP-122721 Dapitant Elinzanetant Ezlopitant Figopitant FK-888 Fosaprepitant Fosnetupitant GR-203040 GW-597599 HSP-117...
Word Count : 983
Last Update: 2022-08-27T08:42:55Z
Casopitant CI-1021 CP-96345 CP-99994 CP-122721 Dapitant Elinzanetant Ezlopitant Figopitant FK-888 Fosaprepitant Fosnetupitant GR-203040 GW-597599 HSP-117...
Word Count : 148
Last Update: 2022-04-23T10:11:01Z
Casopitant CI-1021 CP-96345 CP-99994 CP-122721 Dapitant Elinzanetant Ezlopitant Figopitant FK-888 Fosaprepitant Fosnetupitant GR-203040 GW-597599 HSP-117...
Word Count : 183
Last Update: 2023-04-03T09:36:33Z
Casopitant CI-1021 CP-96345 CP-99994 CP-122721 Dapitant Elinzanetant Ezlopitant Figopitant FK-888 Fosaprepitant Fosnetupitant GR-203040 GW-597599 HSP-117...
Word Count : 186
Last Update: 2022-09-06T19:23:09Z
Casopitant CI-1021 CP-96345 CP-99994 CP-122721 Dapitant Elinzanetant Ezlopitant Figopitant FK-888 Fosaprepitant Fosnetupitant GR-203040 GW-597599 HSP-117...
Word Count : 226
Last Update: 2023-01-23T11:29:15Z
Casopitant CI-1021 CP-96345 CP-99994 CP-122721 Dapitant Elinzanetant Ezlopitant Figopitant FK-888 Fosaprepitant Fosnetupitant GR-203040 GW-597599 HSP-117...
Word Count : 273
Last Update: 2024-03-09T23:37:26Z
Casopitant CI-1021 CP-96345 CP-99994 CP-122721 Dapitant Elinzanetant Ezlopitant Figopitant FK-888 Fosaprepitant Fosnetupitant GR-203040 GW-597599 HSP-117...
Word Count : 955
Last Update: 2023-12-03T06:47:57Z
Casopitant CI-1021 CP-96345 CP-99994 CP-122721 Dapitant Elinzanetant Ezlopitant Figopitant FK-888 Fosaprepitant Fosnetupitant GR-203040 GW-597599 HSP-117...
Word Count : 164
Last Update: 2024-01-07T22:18:04Z
Casopitant CI-1021 CP-96345 CP-99994 CP-122721 Dapitant Elinzanetant Ezlopitant Figopitant FK-888 Fosaprepitant Fosnetupitant GR-203040 GW-597599 HSP-117...
Word Count : 294
Last Update: 2023-12-03T15:12:09Z
Casopitant CI-1021 CP-96345 CP-99994 CP-122721 Dapitant Elinzanetant Ezlopitant Figopitant FK-888 Fosaprepitant Fosnetupitant GR-203040 GW-597599 HSP-117...
Word Count : 491
Last Update: 2023-12-22T10:42:13Z
Casopitant CI-1021 CP-96345 CP-99994 CP-122721 Dapitant Elinzanetant Ezlopitant Figopitant FK-888 Fosaprepitant Fosnetupitant GR-203040 GW-597599 HSP-117...
Word Count : 371
Last Update: 2024-03-09T23:36:03Z
Casopitant CI-1021 CP-96345 CP-99994 CP-122721 Dapitant Elinzanetant Ezlopitant Figopitant FK-888 Fosaprepitant Fosnetupitant GR-203040 GW-597599 HSP-117...
Word Count : 1178