Chemical compound
Befetupitant ATC code
2-[3,5-bis(trifluoromethyl)phenyl]-N,2-dimethyl-N-[4-(2-methylphenyl)-6-morpholin-4-ylpyridin-3-yl]propanamide
CAS Number 290296-68-3 Y PubChem CID ChemSpider UNII CompTox Dashboard (EPA ) DTXSID90183270 Formula C 29 H 29 F 6 N 3 O 2 Molar mass 565.560 g·mol−1 3D model (JSmol)
CC1=CC=CC=C1C2=CC(=NC=C2N(C)C(=O)C(C)(C)C3=CC(=CC(=C3)C(F)(F)F)C(F)(F)F)N4CCOCC4
InChI=1S/C29H29F6N3O2/c1-18-7-5-6-8-22(18)23-16-25(38-9-11-40-12-10-38)36-17-24(23)37(4)26(39)27(2,3)19-13-20(28(30,31)32)15-21(14-19)29(33,34)35/h5-8,13-17H,9-12H2,1-4H3
Key:ZGNPLCMMVKCTHM-UHFFFAOYSA-N
Befetupitant (Ro67-5930 ) is a drug developed by Hoffmann-La Roche which acts as a potent and selective antagonist for the NK1 receptor.[1] It was originally developed as a potential antiemetic drug, though development was ultimately discontinued after a related drug netupitant was deemed to be more suitable for clinical development. Befetupitant has however continued to be researched for other possible applications such as treatment of corneal neovascularization.[2]
^ Hoffmann T, Bös M, Stadler H, Schnider P, Hunkeler W, Godel T, et al. (March 2006). "Design and synthesis of a novel, achiral class of highly potent and selective, orally active neurokinin-1 receptor antagonists". Bioorganic & Medicinal Chemistry Letters . 16 (5): 1362–5. doi:10.1016/j.bmcl.2005.11.047. PMID 16332435.
^ Bignami F, Giacomini C, Lorusso A, Aramini A, Rama P, Ferrari G (September 2014). "NK1 receptor antagonists as a new treatment for corneal neovascularization". Investigative Ophthalmology & Visual Science . 55 (10): 6783–94. doi:10.1167/iovs.14-14553. PMID 25228541.
Last Update: 2023-12-03T06:47:57Z
Befetupitant (Ro67-5930) is a drug developed by Hoffmann-La Roche which acts as a potent and selective antagonist for the NK1 receptor. It was originally...
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Last Update: 2023-10-06T03:37:05Z
receptor modulators NK1 Agonists: Substance P Antagonists: Aprepitant Befetupitant Burapitant Casopitant CI-1021 CP-96345 CP-99994 CP-122721 Dapitant Elinzanetant...
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