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Neurokinin B information


Neurokinin B
Identifiers
CAS Number
  • 86933-75-7 checkY
3D model (JSmol)
  • Interactive image
ChemSpider
  • 4470819 ☒N
IUPHAR/BPS
  • 2090
MeSH Neurokinin+B
PubChem CID
  • 55583
CompTox Dashboard (EPA)
  • DTXSID4040890 Edit this at Wikidata
InChI
  • InChI=1S/C55H79N13O14S2/c1-30(2)21-38(50(77)62-36(47(57)74)17-19-83-5)61-43(69)28-59-55(82)46(31(3)4)68-54(81)40(23-33-15-11-8-12-16-33)65-51(78)39(22-32-13-9-7-10-14-32)64-53(80)42(26-45(72)73)67-52(79)41(24-34-27-58-29-60-34)66-49(76)37(18-20-84-6)63-48(75)35(56)25-44(70)71/h7-16,27,29-31,35-42,46H,17-26,28,56H2,1-6H3,(H2,57,74)(H,58,60)(H,59,82)(H,61,69)(H,62,77)(H,63,75)(H,64,80)(H,65,78)(H,66,76)(H,67,79)(H,68,81)(H,70,71)(H,72,73)/t35-,36-,37-,38-,39-,40-,41-,42-,46-/m0/s1 ☒N
    Key: NHXYSAFTNPANFK-HDMCBQFHSA-N ☒N
  • InChI=1/C55H79N13O14S2/c1-30(2)21-38(50(77)62-36(47(57)74)17-19-83-5)61-43(69)28-59-55(82)46(31(3)4)68-54(81)40(23-33-15-11-8-12-16-33)65-51(78)39(22-32-13-9-7-10-14-32)64-53(80)42(26-45(72)73)67-52(79)41(24-34-27-58-29-60-34)66-49(76)37(18-20-84-6)63-48(75)35(56)25-44(70)71/h7-16,27,29-31,35-42,46H,17-26,28,56H2,1-6H3,(H2,57,74)(H,58,60)(H,59,82)(H,61,69)(H,62,77)(H,63,75)(H,64,80)(H,65,78)(H,66,76)(H,67,79)(H,68,81)(H,70,71)(H,72,73)/t35-,36-,37-,38-,39-,40-,41-,42-,46-/m0/s1
    Key: NHXYSAFTNPANFK-HDMCBQFHBC
SMILES
  • CC(C)C[C@@H](C(=O)N[C@@H](CCSC)C(=O)N)NC(=O)CNC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc3c[nH]cn3)NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(=O)O)N
Properties
Chemical formula
 C55H79N13O14S2
Molar mass 1210.43
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
☒N verify (what is checkY☒N ?)
Infobox references

Neurokinin B (NKB) belongs in the family of tachykinin peptides. Neurokinin B is implicated in a variety of human functions and pathways such as the secretion of gonadotropin-releasing hormone.[1] Additionally, NKB is associated with pregnancy in females and maturation in young adults. Reproductive function is highly dependent on levels of both neurokinin B and also the G-protein coupled receptor ligand kisspeptin.[2] The first NKB studies done attempted to resolve why high levels of the peptide may be implicated in pre-eclampsia during pregnancy.[3] NKB, kisspeptin, and dynorphin together are found in the arcuate nucleus (ARC) known as the KNDy subpopulation. This subpopulation is targeted by many steroid hormones and works to form a network that feeds back to GnRH pulse generator.[4]

  1. ^ Goodman, R.L; Coolen, L.M; Lehman, M.N (July 2014). "A Role for Neurokinin B in Pulsatile GnRH Secretion in the Ewe". Neuroendocrinology. 99 (1): 18–32. doi:10.1159/000355285. PMC 3976461. PMID 24008670.
  2. ^ Navarro, VM (2013). "Interactions Between Kisspeptins and Neurokinin B". Kisspeptin Signaling in Reproductive Biology. Advances in Experimental Medicine and Biology. Vol. 784. pp. 325–347. doi:10.1007/978-1-4614-6199-9_15. ISBN 978-1-4614-6198-2. PMC 3858905. PMID 23550013.
  3. ^ Rie, Sakamoto; hisao, Osada; Yoshinori, Litsuka; Kentarou, Masuda; Kenshi, Kaku; Katsuyoshi, Seki; Souei, Sekiya (17 Apr 2003). "Profile of neurokinin B concentrations in maternal and cord blood in normal pregnancy". Clinical Endocrinology. 58 (5): 597–600. doi:10.1046/j.1365-2265.2003.01758.x. PMID 12699441. S2CID 30312551.
  4. ^ Lehman, Michael; Coolen, Lique; Goodman, Robert (August 2010). "Minireview: Kisspeptin/Neurokinin B/ Dynorphin Cells of the Arcuate Nucleus: A central Node in the Control of Gonadotorpin-Releasing Hormone Secretion". Endocrinology. 151 (8): 3479–3489. doi:10.1210/en.2010-0022. PMC 2940527. PMID 20501670.

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Neurokinin 1 (NK1) antagonists (-pitants) are a novel class of medications that possesses unique antidepressant, anxiolytic, and antiemetic properties...

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Puberty

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encoding both neurokinin B as well as the neurokinin B receptor can alter the timing of puberty. The researchers hypothesized that neurokinin B might play...

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KNDy neuron

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Kisspeptin, neurokinin B, and dynorphin (KNDy) neurons are neurons in the hypothalamus of the brain that are central to the hormonal control of reproduction...

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Tachykinin receptor 3

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This gene encodes the receptor for the tachykinin neurokinin 3, also referred to as neurokinin B. A number of selective ligands are available for NK3...

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Fezolinetant

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symptoms) due to menopause. It is a small-molecule, orally active, selective neurokinin-3 (NK3) receptor antagonist which is under development by for the treatment...

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Arcuate nucleus

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kisspeptin, dopamine, substance P, growth hormone–releasing hormone (GHRH), neurokinin B (NKB), β-endorphin, melanocyte-stimulating hormone (MSH), and somatostatin...

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Peptide

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Cathelicidin family Defensin family Substance P Kassinin Neurokinin A Eledoisin Neurokinin B VIP (Vasoactive Intestinal Peptide; PHM27) PACAP Pituitary...

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Tachykinin receptor 1

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The tachykinin receptor 1 (TACR1) also known as neurokinin 1 receptor (NK1R) or substance P receptor (SPR) is a G protein coupled receptor found in the...

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Maropitant

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Maropitant (INN; brand name: Cerenia, used as maropitant citrate (USAN), is a neurokinin-1 (NK1) receptor antagonist developed by Zoetis specifically for the treatment...

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Aprepitant

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such use has not been well studied. Aprepitant belongs to the class of neurokinin-1 receptor antagonists medications. It works by blocking substance P from...

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Substance P

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neurotransmitter and a neuromodulator. Substance P and the closely related neurokinin A (NKA) are produced from a polyprotein precursor after alternative splicing...

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Basal ganglia

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found in the basal ganglia include substance P, neurokinin A, cholecystokinin, neurotensin, neurokinin B, neuropeptide Y, somatostatin, dynorphin, enkephaline...

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Preprotachykinin

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and neurokinin A (also called "substance K"), and the derived neuropeptide K and neurokinin gamma. preprotachykinin-2 (also PPT-2, PPT-II, or PPT-B), which...

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General visceral afferent fiber

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P and other neuropeptides of the tachykinin family, such as neurokinin A and neurokinin B, specifically in the sympathetic portion of these fibres. General...

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Placenta

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For this purpose, the placenta uses several mechanisms : It secretes neurokinin B-containing phosphocholine molecules. This is the same mechanism used...

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TAC3

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Tachykinin-3 is a protein that in humans is encoded by the TAC3 gene. Neurokinin B Tachykinin receptor 3 GRCh38: Ensembl release 89: ENSG00000166863 – Ensembl...

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Tradipitant

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Tradipitant (VLY-686 or LY686017) is an experimental drug that is a neurokinin 1 antagonist. It works by blocking substance P, a small signaling molecule...

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Menopause

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involve complex interplay between the neurotransmitters kisspeptin, neurokinin B, and dynorphin, which are found in KNDy neurons in the infundibular nucleus...

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Waljit Dhillo

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for infertile women undergoing in vitro fertilization, and the role of neurokinin B in the hot flush symptoms of menopausal women. His research paved the...

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Delayed puberty

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the more discreet modulators of the HPG axis including kisspeptin and neurokinin B. In cases of severe delayed puberty secondary to hypogonadism, evaluation...

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Fosaprepitant

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Vestipitant Vofopitant NK2 Agonists: Neurokinin A Antagonists: GR-159897 Ibodutant Nepadutant Saredutant NK3 Agonists: Neurokinin B Senktide Antagonists: Elinzanetant...

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Elinzanetant

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names BAY-3427080 GSK-1144814, NT-814) is an orally active small-molecule neurokinin/tachykinin NK1 receptor and NK3 receptor antagonist which is under development...

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dopamine storage within vesicles; and deprenyl inhibits monoamine oxidase (MAO)-B and thus increases dopamine levels. An agonist is a chemical capable of binding...

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Netupitant

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Netupitant is a selective NK1 receptor antagonist. Netupitant is a selective neurokinin 1 (NK1) receptor antagonist with potential antiemetic activity. Netupitant...

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Pavinetant

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AZ-12472520, AZD-2624), is a small-molecule, orally active, selective neurokinin-3 (NK3) receptor antagonist which was under development by AstraZeneca...

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