Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Chemical compound
Substance P (SP) is an undecapeptide (a peptide composed of a chain of 11 amino acid residues)[1] and a type of neuropeptide, belonging to the tachykinin family of neuropeptides. It acts as a neurotransmitter and a neuromodulator.[2][3] Substance P and the closely related neurokinin A (NKA) are produced from a polyprotein precursor after alternative splicing of the preprotachykinin A gene. The deduced amino acid sequence of substance P is as follows:[4]
Arg Pro Lys Pro Gln Gln Phe Phe Gly Leu Met (RPKPQQFFGLM)
with an amide group at the C-terminus.[5]
Substance P is released from the terminals of specific sensory nerves. It is found in the brain and spinal cord and is associated with inflammatory processes and pain.
^"Undecapeptide Definition & Meaning". Meriam-Webster. Retrieved 17 November 2022.
^Harrison S, Geppetti P (Jun 2001). "Substance p". The International Journal of Biochemistry & Cell Biology. 33 (6): 555–76. doi:10.1016/S1357-2725(01)00031-0. PMID 11378438.
^Datar P, Srivastava S, Coutinho E, Govil G (2004). "Substance P: structure, function, and therapeutics". Current Topics in Medicinal Chemistry. 4 (1): 75–103. doi:10.2174/1568026043451636. PMID 14754378. Archived from the original on 2009-08-17. Retrieved 2008-11-01.
^Reece JB, Campbell NA (2005). Biology, 7th Edition. San Francisco: Pearson, Benjamin Cummings. ISBN 9780805371468. OCLC 57368924.
^Wong M, Jeng AY (Jan 1994). "Posttranslational modification of glycine-extended substance P by an alpha-amidating enzyme in cultured sensory neurons of dorsal root ganglia". Journal of Neuroscience Research. 37 (1): 97–102. doi:10.1002/jnr.490370113. PMID 7511706. S2CID 31252390.
SubstanceP (SP) is an undecapeptide (a peptide composed of a chain of 11 amino acid residues) and a type of neuropeptide, belonging to the tachykinin...
Substance theory, or substance–attribute theory, is an ontological theory positing that objects are constituted each by a substance and properties borne...
especially substanceP. SubstanceP has been found to have an important role in inducing pain; however, there is no confirmation that substanceP directly...
Humic substances (HS) are coloured recalcitrant organic compounds naturally formed during long-term decomposition and transformation of biomass residues...
Magainin family Cecropin family Cathelicidin family Defensin family SubstanceP Kassinin Neurokinin A Eledoisin Neurokinin B VIP (Vasoactive Intestinal...
No Substance is the tenth full-length album by the punk rock band Bad Religion. It was the band's third (or fourth, if the reissue of Recipe for Hate...
graded Abbreviation for species Simulated patient, for medical training SubstanceP, a neuropeptide Status post, notes about sequelae with reference to their...
Substance abuse, also known as drug abuse, is the use of a drug in amounts or by methods that are harmful to the individual or others. It is a form of...
production of more substanceP as well as substance S. However, substance S inhibits the production of substanceP; if S diffuses more readily than P, sharp waves...
The Controlled Substances Act (CSA) is the statute establishing federal U.S. drug policy under which the manufacture, importation, possession, use, and...
that most of the gut peptides, such as secretin, cholecystokinin or substanceP, were found to play a role of neurotransmitters and neuromodulators in...
Substance use disorder (SUD) is the persistent use of drugs despite the substantial harm and adverse consequences to one's own self and others, as a result...
(July 2003). "The inhibitory effects of ketamine and pentobarbital on substancep receptors expressed in Xenopus oocytes". Anesthesia and Analgesia. 97...
structure to substanceP, the key neurotransmitter in causing vomiting, which allows it to act as an antagonist and bind to the substanceP receptor neurokinin...
for substanceP. Stimulation of different receptors are involved in different pathways leading to emesis, in the final common pathway substanceP appears...
tachykinin receptor 1 (TACR1) also known as neurokinin 1 receptor (NK1R) or substanceP receptor (SPR) is a G protein coupled receptor found in the central nervous...
neurokinin-1 receptor antagonists medications. It works by blocking substanceP from attaching to the NK1 receptors. Aprepitant was approved for medical...
In chemistry, the amount of substance (symbol n) in a given sample of matter is defined as a ratio (n = N/NA) between the number of elementary entities...
and vomiting include acetylcholine, dopamine, histamine (H1 receptor), substanceP (NK-1 receptor), and serotonin (5-HT3 receptor). There are also opioid...
inhibition of pro-inflammatory neuropeptide release, including CGRP and substanceP. Triptans are selective agents for 5-HT1B and 5-HT1D and have low or...
periphery. The activation of the mu-opioid receptor inhibits the release of substanceP from these incoming first-order neurons and, in turn, inhibits the activation...
Substance intoxication is a transient condition of altered consciousness and behavior associated with recent use of a substance. It is often maladaptive...
Galectin-3. There is considerable functional overlap and interaction between SubstanceP (SP), the natural ligand for the neurokinin type 1 receptor (NK1R, a...
Substance (also known as Substance 1987) is a compilation album by English alternative dance band New Order. It was released in August 1987 by Factory...
A (formerly known as substance K), neuropeptide K (which has also been called neurokinin K), neuropeptide gamma, and SubstanceP. Alpha, beta, and gamma...
heat capacity (symbol c) of a substance is the amount of heat that must be added to one unit of mass of the substance in order to cause an increase of...
erosion and cartilage loss via release of IL-1, prostaglandins, and substanceP by macrophages. In ophthalmology, pannus refers to the growth of blood...
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