Chemical compound
Elinzanetant Other names BAY-3427080; GSK-1144814; NT-814 Routes of administration Oral administration
N -[6-[(7S ,9aS )-7-(hydroxymethyl)-3,4,6,7,9,9a -hexahydro-1H -pyrazino[2,1-c][1,4]oxazin-8-yl]-4-(4-fluoro-2-methylphenyl)pyridin-3-yl]-2-[3,5-bis(trifluoromethyl)phenyl]-N ,2-dimethylpropanamide
CAS Number PubChem CID ChemSpider UNII KEGG Formula C 33 H 35 F 7 N 4 O 3 Molar mass 668.657 g·mol−1 3D model (JSmol)
CC1=C(C=CC(=C1)F)C2=CC(=NC=C2N(C)C(=O)C(C)(C)C3=CC(=CC(=C3)C(F)(F)F)C(F)(F)F)N4C[C@H]5COCCN5C[C@H]4CO
InChI=1S/C33H35F7N4O3/c1-19-9-23(34)5-6-26(19)27-13-29(44-16-25-18-47-8-7-43(25)15-24(44)17-45)41-14-28(27)42(4)30(46)31(2,3)20-10-21(32(35,36)37)12-22(11-20)33(38,39)40/h5-6,9-14,24-25,45H,7-8,15-18H2,1-4H3/t24-,25-/m0/s1
Key:DWRIJNIPBUFCQS-DQEYMECFSA-N
Elinzanetant (developmental code names BAY-3427080 GSK-1144814 , NT-814 ) is an orally active small-molecule neurokinin/tachykinin NK1 receptor and NK3 receptor antagonist which is under development by Bayer, GlaxoSmithKline, and NeRRe Therapeutics for the treatment of hot flashes and "sex hormone disorders".[1] [2] It has been found to relieve hot flashes in postmenopausal women and to dose-dependently suppress luteinizing hormone, estradiol, and progesterone levels in premenopausal women.[2] [3] As of August 2021, elinzanetant is in phase 2 clinical trials for hot flashes and "sex hormone disorders".[1] It was also under development for the treatment of schizophrenia and opioid-related disorders, but development was discontinued for these uses.[1]
^ a b c "Elinzanetant - Bayer". Adis Insight . Springer Nature Switzerland AG.
^ a b Depypere H, Lademacher C, Siddiqui E, Fraser GL (July 2021). "Fezolinetant in the treatment of vasomotor symptoms associated with menopause". Expert Opinion on Investigational Drugs . 30 (7): 681–694. doi:10.1080/13543784.2021.1893305 . hdl:1854/LU-8758954 . PMID 33724119.
^ Pawsey S, Mills EG, Ballantyne E, Donaldson K, Kerr M, Trower M, Dhillo WS (July 2021). "Elinzanetant (NT-814), a Neurokinin 1,3 Receptor Antagonist, Reduces Estradiol and Progesterone in Healthy Women". The Journal of Clinical Endocrinology and Metabolism . 106 (8): e3221–e3234. doi:10.1210/clinem/dgab108. PMC 8277204 . PMID 33624806.
Last Update: 2024-01-04T19:10:30Z
Elinzanetant (developmental code names BAY-3427080 GSK-1144814, NT-814) is an orally active small-molecule neurokinin/tachykinin NK1 receptor and NK3 receptor...
Word Count : 223
Last Update: 2023-10-06T03:37:05Z
Befetupitant Burapitant Casopitant CI-1021 CP-96345 CP-99994 CP-122721 Dapitant Elinzanetant Ezlopitant Figopitant FK-888 Fosaprepitant Fosnetupitant GR-203040 GW-597599...
Word Count : 1737
Last Update: 2023-12-05T03:23:30Z
Befetupitant Burapitant Casopitant CI-1021 CP-96345 CP-99994 CP-122721 Dapitant Elinzanetant Ezlopitant Figopitant FK-888 Fosaprepitant Fosnetupitant GR-203040 GW-597599...
Word Count : 3270
Last Update: 2024-03-30T06:32:48Z
Befetupitant Burapitant Casopitant CI-1021 CP-96345 CP-99994 CP-122721 Dapitant Elinzanetant Ezlopitant Figopitant FK-888 Fosaprepitant Fosnetupitant GR-203040 GW-597599...
Word Count : 1260
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Befetupitant Burapitant Casopitant CI-1021 CP-96345 CP-99994 CP-122721 Dapitant Elinzanetant Ezlopitant Figopitant FK-888 Fosaprepitant Fosnetupitant GR-203040 GW-597599...
Word Count : 248
Last Update: 2022-08-21T16:08:12Z
Befetupitant Burapitant Casopitant CI-1021 CP-96345 CP-99994 CP-122721 Dapitant Elinzanetant Ezlopitant Figopitant FK-888 Fosaprepitant Fosnetupitant GR-203040 GW-597599...
Word Count : 240
Last Update: 2024-03-17T19:07:38Z
Befetupitant Burapitant Casopitant CI-1021 CP-96345 CP-99994 CP-122721 Dapitant Elinzanetant Ezlopitant Figopitant FK-888 Fosaprepitant Fosnetupitant GR-203040 GW-597599...
Word Count : 5337
Last Update: 2023-01-29T12:55:18Z
Befetupitant Burapitant Casopitant CI-1021 CP-96345 CP-99994 CP-122721 Dapitant Elinzanetant Ezlopitant Figopitant FK-888 Fosaprepitant Fosnetupitant GR-203040 GW-597599...
Word Count : 196
Last Update: 2022-03-05T22:44:27Z
Befetupitant Burapitant Casopitant CI-1021 CP-96345 CP-99994 CP-122721 Dapitant Elinzanetant Ezlopitant Figopitant FK-888 Fosaprepitant Fosnetupitant GR-203040 GW-597599...
Word Count : 145
Last Update: 2024-01-05T23:33:06Z
Befetupitant Burapitant Casopitant CI-1021 CP-96345 CP-99994 CP-122721 Dapitant Elinzanetant Ezlopitant Figopitant FK-888 Fosaprepitant Fosnetupitant GR-203040 GW-597599...
Word Count : 236
Last Update: 2024-01-30T01:45:55Z
Befetupitant Burapitant Casopitant CI-1021 CP-96345 CP-99994 CP-122721 Dapitant Elinzanetant Ezlopitant Figopitant FK-888 Fosaprepitant Fosnetupitant GR-203040 GW-597599...
Word Count : 669
Last Update: 2023-01-26T02:47:57Z
Befetupitant Burapitant Casopitant CI-1021 CP-96345 CP-99994 CP-122721 Dapitant Elinzanetant Ezlopitant Figopitant FK-888 Fosaprepitant Fosnetupitant GR-203040 GW-597599...
Word Count : 983
Last Update: 2024-03-14T07:12:16Z
Befetupitant Burapitant Casopitant CI-1021 CP-96345 CP-99994 CP-122721 Dapitant Elinzanetant Ezlopitant Figopitant FK-888 Fosaprepitant Fosnetupitant GR-203040 GW-597599...
Word Count : 868
Last Update: 2024-03-23T23:38:37Z
Befetupitant Burapitant Casopitant CI-1021 CP-96345 CP-99994 CP-122721 Dapitant Elinzanetant Ezlopitant Figopitant FK-888 Fosaprepitant Fosnetupitant GR-203040 GW-597599...
Word Count : 2206
Last Update: 2022-09-06T19:23:09Z
Befetupitant Burapitant Casopitant CI-1021 CP-96345 CP-99994 CP-122721 Dapitant Elinzanetant Ezlopitant Figopitant FK-888 Fosaprepitant Fosnetupitant GR-203040 GW-597599...
Word Count : 226
Last Update: 2023-01-23T11:29:15Z
Befetupitant Burapitant Casopitant CI-1021 CP-96345 CP-99994 CP-122721 Dapitant Elinzanetant Ezlopitant Figopitant FK-888 Fosaprepitant Fosnetupitant GR-203040 GW-597599...
Word Count : 273
Last Update: 2022-04-23T10:11:01Z
Befetupitant Burapitant Casopitant CI-1021 CP-96345 CP-99994 CP-122721 Dapitant Elinzanetant Ezlopitant Figopitant FK-888 Fosaprepitant Fosnetupitant GR-203040 GW-597599...
Word Count : 183
Last Update: 2023-12-03T15:12:09Z
Befetupitant Burapitant Casopitant CI-1021 CP-96345 CP-99994 CP-122721 Dapitant Elinzanetant Ezlopitant Figopitant FK-888 Fosaprepitant Fosnetupitant GR-203040 GW-597599...
Word Count : 491
Last Update: 2024-02-13T05:48:14Z
Befetupitant Burapitant Casopitant CI-1021 CP-96345 CP-99994 CP-122721 Dapitant Elinzanetant Ezlopitant Figopitant FK-888 Fosaprepitant Fosnetupitant GR-203040 GW-597599...
Word Count : 2873
Last Update: 2024-03-09T23:37:26Z
Senktide – 7-amino acid polypeptide, NK3 selective, CAS# 106128-89-6 Elinzanetant (BAY-3427080 GSK-1144814, NT-814) Fezolinetant (ESN-364) Osanetant (SR-142...
Word Count : 955
Last Update: 2024-04-29T04:15:33Z
5-amino acid polypeptide chain. CAS# 133156-06-6 Aprepitant Casopitant Elinzanetant Ezlopitant Fosaprepitant Lanepitant Maropitant Vestipitant L-733,060...
Word Count : 2396
Last Update: 2023-10-01T01:29:59Z
Befetupitant Burapitant Casopitant CI-1021 CP-96345 CP-99994 CP-122721 Dapitant Elinzanetant Ezlopitant Figopitant FK-888 Fosaprepitant Fosnetupitant GR-203040 GW-597599...
Word Count : 1716
Last Update: 2023-04-03T09:36:33Z
Befetupitant Burapitant Casopitant CI-1021 CP-96345 CP-99994 CP-122721 Dapitant Elinzanetant Ezlopitant Figopitant FK-888 Fosaprepitant Fosnetupitant GR-203040 GW-597599...
Word Count : 186
Last Update: 2023-12-03T06:47:57Z
Befetupitant Burapitant Casopitant CI-1021 CP-96345 CP-99994 CP-122721 Dapitant Elinzanetant Ezlopitant Figopitant FK-888 Fosaprepitant Fosnetupitant GR-203040 GW-597599...
Word Count : 164
Last Update: 2023-12-22T10:42:13Z
Befetupitant Burapitant Casopitant CI-1021 CP-96345 CP-99994 CP-122721 Dapitant Elinzanetant Ezlopitant Figopitant FK-888 Fosaprepitant Fosnetupitant GR-203040 GW-597599...
Word Count : 371
Last Update: 2022-08-27T08:42:55Z
Befetupitant Burapitant Casopitant CI-1021 CP-96345 CP-99994 CP-122721 Dapitant Elinzanetant Ezlopitant Figopitant FK-888 Fosaprepitant Fosnetupitant GR-203040 GW-597599...
Word Count : 148