Talnetant information

Talnetant
Clinical data
ATC code	none;
Identifiers
	IUPAC name 3-hydroxy-2-phenyl-N-(1-phenylpropyl)quinoline-4-carboxamide;
CAS Number	174636-32-9 ;
PubChem CID	133090;
IUPHAR/BPS	2124;
ChemSpider	117450 ;
UNII	CZ3T9T146K;
ECHA InfoCard	100.236.526
Chemical and physical data
Formula	C25H22N2O2
Molar mass	382.463 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CCC(C1=CC=CC=C1)NC(=O)C2=C(C(=NC3=CC=CC=C32)C4=CC=CC=C4)O;
	InChI InChI=1S/C25H22N2O2/c1-2-20(17-11-5-3-6-12-17)27-25(29)22-19-15-9-10-16-21(19)26-23(24(22)28)18-13-7-4-8-14-18/h3-16,20,28H,2H2,1H3,(H,27,29) ; Key:BIAVGWDGIJKWRM-UHFFFAOYSA-N ;
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Talnetant (SB-223,412) is a neurokinin 3 receptor antagonist developed by GlaxoSmithKline, which is being researched for several functions (primarily treatment of irritable bowel syndrome, despite a 2007 study finding no statistically significant improvement in rectal hypersensitivity over placebo). Its use as a potential antipsychotic drug for the treatment of schizophrenia has also been discontinued.^[1]^[2]^[3]^[4]

^ "UPDATE 1-GlaxoSmithKline prunes new drug pipeline". Reuters. Oct 15, 2007.
^ Evangelista S (July 2005). "Talnetant GlaxoSmithKline". Current Opinion in Investigational Drugs. 6 (7): 717–21. PMID 16044668.
^ Houghton LA, Cremonini F, Camilleri M, Busciglio I, Fell C, Cox V, et al. (September 2007). "Effect of the NK(3) receptor antagonist, talnetant, on rectal sensory function and compliance in healthy humans". Neurogastroenterology and Motility. 19 (9): 732–43. doi:10.1111/j.1365-2982.2007.00934.x. PMID 17727393. S2CID 11876042.
^ Dawson LA, Cato KJ, Scott C, Watson JM, Wood MD, Foxton R, et al. (June 2008). "In vitro and in vivo characterization of the non-peptide NK3 receptor antagonist SB-223412 (talnetant): potential therapeutic utility in the treatment of schizophrenia". Neuropsychopharmacology. 33 (7): 1642–52. doi:10.1038/sj.npp.1301549. PMID 17728699.

[1] "UPDATE 1-GlaxoSmithKline prunes new drug pipeline". Reuters. Oct 15, 2007.

[2] Evangelista S (July 2005). "Talnetant GlaxoSmithKline". Current Opinion in Investigational Drugs. 6 (7): 717–21. PMID 16044668.

[3] Houghton LA, Cremonini F, Camilleri M, Busciglio I, Fell C, Cox V, et al. (September 2007). "Effect of the NK(3) receptor antagonist, talnetant, on rectal sensory function and compliance in healthy humans". Neurogastroenterology and Motility. 19 (9): 732–43. doi:10.1111/j.1365-2982.2007.00934.x. PMID 17727393. S2CID 11876042.

[4] Dawson LA, Cato KJ, Scott C, Watson JM, Wood MD, Foxton R, et al. (June 2008). "In vitro and in vivo characterization of the non-peptide NK3 receptor antagonist SB-223412 (talnetant): potential therapeutic utility in the treatment of schizophrenia". Neuropsychopharmacology. 33 (7): 1642–52. doi:10.1038/sj.npp.1301549. PMID 17728699.

Talnetant information

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Talnetant

Elinzanetant

Maropitant

Pfitzinger reaction

Fezolinetant

Aprepitant

Substance P

Fosaprepitant

NK1 receptor antagonist

Tradipitant

Tachykinin receptor 1

Tachykinin peptides

Casopitant

Rolapitant

Pavinetant

Tachykinin receptor 3

Netupitant

Vestipitant

Orvepitant

Neurokinin A

Ibodutant

Nepadutant

Vofopitant

Osanetant

Neurokinin B

Tachykinin receptor

Saredutant

Serlopitant

Clinical data

ATC code	none
Identifiers
IUPAC name 3-hydroxy-2-phenyl-N-(1-phenylpropyl)quinoline-4-carboxamide
CAS Number	174636-32-9^Y
PubChem CID	133090
IUPHAR/BPS	2124
ChemSpider	117450^N
UNII	CZ3T9T146K
ECHA InfoCard	100.236.526
Chemical and physical data
Formula	C₂₅H₂₂N₂O₂
Molar mass	382.463 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES CCC(C1=CC=CC=C1)NC(=O)C2=C(C(=NC3=CC=CC=C32)C4=CC=CC=C4)O
InChI InChI=1S/C25H22N2O2/c1-2-20(17-11-5-3-6-12-17)27-25(29)22-19-15-9-10-16-21(19)26-23(24(22)28)18-13-7-4-8-14-18/h3-16,20,28H,2H2,1H3,(H,27,29)^N Key:BIAVGWDGIJKWRM-UHFFFAOYSA-N^N
^NY (what is this?) (verify)