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Fosaprepitant information


Fosaprepitant
Skeletal formula of fosaprepitant
Space-filling model of the fosaprepitant molecule
Clinical data
Trade namesEmend, Ivemend
AHFS/Drugs.comMicromedex Detailed Consumer Information
MedlinePlusa604003
License data
  • EU EMA: by INN
  • US DailyMed: Fosaprepitant
  • US FDA: Fosaprepitant
Pregnancy
category
  • AU: B2[1]
Routes of
administration		Intravenous
ATC code
  • A04AD12 (WHO)
Legal status
Legal status
  • AU: S4 (Prescription only)[2][3]
  • UK: POM (Prescription only)
  • US: ℞-only[4]
  • EU: Rx-only[5]
Pharmacokinetic data
Bioavailabilityn/a
Protein binding>95% (aprepitant)
MetabolismTo aprepitant
Elimination half-life9 to 13 hours (aprepitant)
Identifiers
IUPAC name
  • [3-{[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl] ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl}-5-oxo- 2H-1,2,4-triazol-1-yl]phosphonic acid
CAS Number
  • 172673-20-0 checkY
    265121-04-8 (dimeglumine)
PubChem CID
  • 219090
IUPHAR/BPS
  • 7623
DrugBank
  • DB06717 ☒N
ChemSpider
  • 189912 ☒N
UNII
  • 6L8OF9XRDC
KEGG
  • D06597 ☒N
ChEBI
  • CHEBI:64321 ☒N
ChEMBL
  • ChEMBL1199324 ☒N
CompTox Dashboard (EPA)
  • DTXSID801021651 Edit this at Wikidata
Chemical and physical data
FormulaC23H22F7N4O6P
Molar mass614.414 g·mol−1
3D model (JSmol)
  • Interactive image
SMILES
  • C[C@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)O[C@@H]2[C@@H](N(CCO2)Cc3[nH]c(=O)n(n3)P(=O)(O)O)c4ccc(cc4)F
InChI
  • InChI=1S/C23H22F7N4O6P/c1-12(14-8-15(22(25,26)27)10-16(9-14)23(28,29)30)40-20-19(13-2-4-17(24)5-3-13)33(6-7-39-20)11-18-31-21(35)34(32-18)41(36,37)38/h2-5,8-10,12,19-20H,6-7,11H2,1H3,(H,31,32,35)(H2,36,37,38)/t12-,19+,20-/m1/s1 ☒N
  • Key:BARDROPHSZEBKC-OITMNORJSA-N ☒N
 ☒NcheckY (what is this?)  (verify)

Fosaprepitant, sold under the brand names Emend (US) and Ivemend (EU) among others, is an antiemetic medication,[6] administered intravenously. It is a prodrug of aprepitant.

Fosaprepitant was developed by Merck & Co. and was approved for medical use in the United States,[7] and in the European Union in January 2008.[5]

  1. ^ "Prescribing medicines in pregnancy database". Therapeutic Goods Administration (TGA). 21 June 2022. Archived from the original on 2 March 2023. Retrieved 28 April 2023.
  2. ^ "Emend IV fosaprepitant 150mg (as fosaprepitant dimeglumine) powder for injection vial (167061)". Therapeutic Goods Administration (TGA). 27 May 2022. Retrieved 28 April 2023.
  3. ^ "Fosaprepitant MSN (Accelagen Pty Ltd)". Therapeutic Goods Administration (TGA). 11 November 2022. Archived from the original on 18 March 2023. Retrieved 28 April 2023.
  4. ^ "Emend- fosaprepitant dimeglumine injection, powder, lyophilized, for solution". DailyMed. 2 May 2022. Archived from the original on 1 December 2021. Retrieved 27 September 2022.
  5. ^ a b "Ivemend EPAR". European Medicines Agency. 17 September 2018. Archived from the original on 31 December 2021. Retrieved 27 September 2022.
  6. ^ Garnock-Jones KP (September 2016). "Fosaprepitant Dimeglumine: A Review in the Prevention of Nausea and Vomiting Associated with Chemotherapy". Drugs. 76 (14): 1365–72. doi:10.1007/s40265-016-0627-7. PMID 27510503. S2CID 30018182.
  7. ^ "Drugs.com, FDA Approves Emend (fosaprepitant dimeglumine) for Injection, Merck's New Intravenous Therapy, for Use in Combination with Other Antiemetics for Prevention of Nausea and Vomiting Caused by Chemotherapy". Archived from the original on 2008-04-09. Retrieved 2008-03-15.

and 27 Related for: Fosaprepitant information

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Fosaprepitant

Last Update:

Fosaprepitant, sold under the brand names Emend (US) and Ivemend (EU) among others, is an antiemetic medication, administered intravenously. It is a prodrug...

Word Count : 248

Intravenous therapy

Last Update:

to be better suited for IV administration, forming a prodrug such as fosaprepitant. This can be for pharmacokinetic reasons or to delay the effect of the...

Word Count : 7182

Aprepitant

Last Update:

approved by the US Food and Drug Administration (FDA) in 2003. In 2008, fosaprepitant, an intravenous form of aprepitant was approved in the United States...

Word Count : 2210

Maropitant

Last Update:

CP-99994 CP-122721 Dapitant Elinzanetant Ezlopitant Figopitant FK-888 Fosaprepitant Fosnetupitant GR-203040 GW-597599 HSP-117 L-733,060 L-741,671 L-743...

Word Count : 1737

CYP3A4

Last Update:

(analgesic), cafestol (in unfiltered coffee) cilostazol, cimetidine, fosaprepitant, lomitapide, orphenadrine, omeprazole (proton pump inhibitor), quercetin...

Word Count : 7814

Substance P

Last Update:

CP-99994 CP-122721 Dapitant Elinzanetant Ezlopitant Figopitant FK-888 Fosaprepitant Fosnetupitant GR-203040 GW-597599 HSP-117 L-733,060 L-741,671 L-743...

Word Count : 5337

Fezolinetant

Last Update:

CP-99994 CP-122721 Dapitant Elinzanetant Ezlopitant Figopitant FK-888 Fosaprepitant Fosnetupitant GR-203040 GW-597599 HSP-117 L-733,060 L-741,671 L-743...

Word Count : 1279

Tachykinin peptides

Last Update:

Examples of tachykinin antagonists include: Aprepitant Casopitant Fosaprepitant Maropitant Nepadutant Osanetant Saredutant Talnetant Tachykinin InterPro: IPR008215...

Word Count : 1120

Elinzanetant

Last Update:

CP-99994 CP-122721 Dapitant Elinzanetant Ezlopitant Figopitant FK-888 Fosaprepitant Fosnetupitant GR-203040 GW-597599 HSP-117 L-733,060 L-741,671 L-743...

Word Count : 223

NK1 receptor antagonist

Last Update:

use. A water-soluble phosphoryl prodrug for intravenous use, called fosaprepitant, is also available and is marketed as Ivemend. Aprepitant was also believed...

Word Count : 3270

Tachykinin receptor 1

Last Update:

chain. CAS# 133156-06-6 Aprepitant Casopitant Elinzanetant Ezlopitant Fosaprepitant Lanepitant Maropitant Vestipitant L-733,060 L-741,671 L-742,694 RP-67580...

Word Count : 2396

Casopitant

Last Update:

CP-99994 CP-122721 Dapitant Elinzanetant Ezlopitant Figopitant FK-888 Fosaprepitant Fosnetupitant GR-203040 GW-597599 HSP-117 L-733,060 L-741,671 L-743...

Word Count : 240

Pavinetant

Last Update:

CP-99994 CP-122721 Dapitant Elinzanetant Ezlopitant Figopitant FK-888 Fosaprepitant Fosnetupitant GR-203040 GW-597599 HSP-117 L-733,060 L-741,671 L-743...

Word Count : 236

Rolapitant

Last Update:

CP-99994 CP-122721 Dapitant Elinzanetant Ezlopitant Figopitant FK-888 Fosaprepitant Fosnetupitant GR-203040 GW-597599 HSP-117 L-733,060 L-741,671 L-743...

Word Count : 868

Ibodutant

Last Update:

CP-99994 CP-122721 Dapitant Elinzanetant Ezlopitant Figopitant FK-888 Fosaprepitant Fosnetupitant GR-203040 GW-597599 HSP-117 L-733,060 L-741,671 L-743...

Word Count : 145

Osanetant

Last Update:

CP-99994 CP-122721 Dapitant Elinzanetant Ezlopitant Figopitant FK-888 Fosaprepitant Fosnetupitant GR-203040 GW-597599 HSP-117 L-733,060 L-741,671 L-743...

Word Count : 983

Tachykinin receptor

Last Update:

CP-99994 CP-122721 Dapitant Elinzanetant Ezlopitant Figopitant FK-888 Fosaprepitant Fosnetupitant GR-203040 GW-597599 HSP-117 L-733,060 L-741,671 L-743...

Word Count : 148

Netupitant

Last Update:

CP-99994 CP-122721 Dapitant Elinzanetant Ezlopitant Figopitant FK-888 Fosaprepitant Fosnetupitant GR-203040 GW-597599 HSP-117 L-733,060 L-741,671 L-743...

Word Count : 669

Neurokinin B

Last Update:

CP-99994 CP-122721 Dapitant Elinzanetant Ezlopitant Figopitant FK-888 Fosaprepitant Fosnetupitant GR-203040 GW-597599 HSP-117 L-733,060 L-741,671 L-743...

Word Count : 1716

Vestipitant

Last Update:

tinnitus and insomnia. NK1 receptor antagonist Aprepitant Casopitant Fosaprepitant L-733,060 Maropitant "International Nonproprietary Names for Pharmaceutical...

Word Count : 226

Nepadutant

Last Update:

CP-99994 CP-122721 Dapitant Elinzanetant Ezlopitant Figopitant FK-888 Fosaprepitant Fosnetupitant GR-203040 GW-597599 HSP-117 L-733,060 L-741,671 L-743...

Word Count : 177

Orvepitant

Last Update:

CP-99994 CP-122721 Dapitant Elinzanetant Ezlopitant Figopitant FK-888 Fosaprepitant Fosnetupitant GR-203040 GW-597599 HSP-117 L-733,060 L-741,671 L-743...

Word Count : 183

Vofopitant

Last Update:

CP-99994 CP-122721 Dapitant Elinzanetant Ezlopitant Figopitant FK-888 Fosaprepitant Fosnetupitant GR-203040 GW-597599 HSP-117 L-733,060 L-741,671 L-743...

Word Count : 273

Tradipitant

Last Update:

CP-99994 CP-122721 Dapitant Elinzanetant Ezlopitant Figopitant FK-888 Fosaprepitant Fosnetupitant GR-203040 GW-597599 HSP-117 L-733,060 L-741,671 L-743...

Word Count : 491

Befetupitant

Last Update:

CP-99994 CP-122721 Dapitant Elinzanetant Ezlopitant Figopitant FK-888 Fosaprepitant Fosnetupitant GR-203040 GW-597599 HSP-117 L-733,060 L-741,671 L-743...

Word Count : 164

Ezlopitant

Last Update:

CP-99994 CP-122721 Dapitant Elinzanetant Ezlopitant Figopitant FK-888 Fosaprepitant Fosnetupitant GR-203040 GW-597599 HSP-117 L-733,060 L-741,671 L-743...

Word Count : 237

Neurokinin A

Last Update:

CP-99994 CP-122721 Dapitant Elinzanetant Ezlopitant Figopitant FK-888 Fosaprepitant Fosnetupitant GR-203040 GW-597599 HSP-117 L-733,060 L-741,671 L-743...

Word Count : 2873
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