Chemical compound
Ibodutant Other names 6-methyl-N -[1-[[(2R )-1-[[1-(oxan-4-ylmethyl)piperidin-4- yl]methylamino]-1-oxo-3-phenylpropan-2-yl]carbamoyl]cyclopentyl]-1-benzothiophene-2-carboxamide Routes of administration Oral ATC code
N α-[(1-{[(6-methyl-1-benzothien-2-yl)carbonyl]amino}cyclopentyl)carbonyl]-N -{[1-(tetrahydro-2H -pyran-4-ylmethyl)piperidin-4-yl]methyl}-D -phenylalaninamide
CAS Number 522664-63-7 Y PubChem CID IUPHAR/BPS ChemSpider 9702281 N UNII CompTox Dashboard (EPA ) DTXSID20966639 Formula C 37 H 48 N 4 O 4 S Molar mass 644.88 g·mol−1 3D model (JSmol)
CC1=CC2=C(C=C1)C=C(S2)C(=O)NC3(CCCC3)C(=O)NC(CC4=CC=CC=C4)C(=O)NCC5CCN(CC5)CC6CCOCC6
InChI=1S/C37H48N4O4S/c1-26-9-10-30-23-33(46-32(30)21-26)35(43)40-37(15-5-6-16-37)36(44)39-31(22-27-7-3-2-4-8-27)34(42)38-24-28-11-17-41(18-12-28)25-29-13-19-45-20-14-29/h2-4,7-10,21,23,28-29,31H,5-6,11-20,22,24-25H2,1H3,(H,38,42)(H,39,44)(H,40,43)/t31-/m1/s1
N Key:YQYSVMKCMIUCHY-WJOKGBTCSA-N
N
N Y (what is this?) (verify)
Ibodutant was a candidate drug for irritable bowel syndrome diarrhea, developed by The Menarini Group. As of March 2015[update] , it underwent a multicentre double blind efficacy clinical study. Ibodutant selectively blocks the tachykinin receptor NK2 , with blockade practically complete in nanomolar concentrations. A phase 2 trial in Europe (the IRIS-2 trial) completed in May 2012 with positive results. A 52-week phase 3 study was terminated as of 2015 because of low response and negative results of study NAK-06.[1]
^ "Clinical Trials Database". Menarini Group. Retrieved 11 March 2015 .
Last Update: 2022-03-05T22:44:27Z
Ibodutant was a candidate drug for irritable bowel syndrome diarrhea, developed by The Menarini Group. As of March 2015[update], it underwent a multicentre...
Word Count : 145
Last Update: 2024-02-21T09:59:26Z
Directors appointed Elcin Barker Ergun as the company's CEO. Dexketoprofen Ibodutant Berlin Chemie "Handling with missing data in clinical trials for time-to-event...
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Last Update: 2023-10-06T03:37:05Z
Vestipitant Vofopitant NK2 Agonists: Neurokinin A Antagonists: GR-159897 Ibodutant Nepadutant Saredutant NK3 Agonists: Neurokinin B Senktide Antagonists:...
Word Count : 1737
Last Update: 2024-03-17T19:07:38Z
Vestipitant Vofopitant NK2 Agonists: Neurokinin A Antagonists: GR-159897 Ibodutant Nepadutant Saredutant NK3 Agonists: Neurokinin B Senktide Antagonists:...
Word Count : 5337
Last Update: 2024-03-30T06:32:48Z
Vestipitant Vofopitant NK2 Agonists: Neurokinin A Antagonists: GR-159897 Ibodutant Nepadutant Saredutant NK3 Agonists: Neurokinin B Senktide Antagonists:...
Word Count : 1260
Last Update: 2023-12-03T22:17:45Z
saredutant for the treatment of major depressive disorder. GR-159,897 Ibodutant Nepadutant Hopkins CR (October 2010). "ACS chemical neuroscience molecule...
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Last Update: 2023-12-20T19:49:29Z
Vestipitant Vofopitant NK2 Agonists: Neurokinin A Antagonists: GR-159897 Ibodutant Nepadutant Saredutant NK3 Agonists: Neurokinin B Senktide Antagonists:...
Word Count : 248
Last Update: 2024-06-03T13:48:33Z
Vestipitant Vofopitant NK2 Agonists: Neurokinin A Antagonists: GR-159897 Ibodutant Nepadutant Saredutant NK3 Agonists: Neurokinin B Senktide Antagonists:...
Word Count : 2210
Last Update: 2022-08-21T16:08:12Z
Vestipitant Vofopitant NK2 Agonists: Neurokinin A Antagonists: GR-159897 Ibodutant Nepadutant Saredutant NK3 Agonists: Neurokinin B Senktide Antagonists:...
Word Count : 240
Last Update: 2024-01-05T23:33:06Z
Vestipitant Vofopitant NK2 Agonists: Neurokinin A Antagonists: GR-159897 Ibodutant Nepadutant Saredutant NK3 Agonists: Neurokinin B Senktide Antagonists:...
Word Count : 236
Last Update: 2024-01-04T19:10:30Z
Vestipitant Vofopitant NK2 Agonists: Neurokinin A Antagonists: GR-159897 Ibodutant Nepadutant Saredutant NK3 Agonists: Neurokinin B Senktide Antagonists:...
Word Count : 223
Last Update: 2023-10-01T01:29:59Z
Vestipitant Vofopitant NK2 Agonists: Neurokinin A Antagonists: GR-159897 Ibodutant Nepadutant Saredutant NK3 Agonists: Neurokinin B Senktide Antagonists:...
Word Count : 1716
Last Update: 2023-12-03T15:12:09Z
Vestipitant Vofopitant NK2 Agonists: Neurokinin A Antagonists: GR-159897 Ibodutant Nepadutant Saredutant NK3 Agonists: Neurokinin B Senktide Antagonists:...
Word Count : 491
Last Update: 2024-01-30T01:45:55Z
Vestipitant Vofopitant NK2 Agonists: Neurokinin A Antagonists: GR-159897 Ibodutant Nepadutant Saredutant NK3 Agonists: Neurokinin B Senktide Antagonists:...
Word Count : 669
Last Update: 2024-04-29T04:15:33Z
Vestipitant Vofopitant NK2 Agonists: Neurokinin A Antagonists: GR-159897 Ibodutant Nepadutant Saredutant NK3 Agonists: Neurokinin B Senktide Antagonists:...
Word Count : 2396
Last Update: 2022-08-27T08:42:55Z
Vestipitant Vofopitant NK2 Agonists: Neurokinin A Antagonists: GR-159897 Ibodutant Nepadutant Saredutant NK3 Agonists: Neurokinin B Senktide Antagonists:...
Word Count : 148
Last Update: 2023-12-05T03:23:30Z
Vestipitant Vofopitant NK2 Agonists: Neurokinin A Antagonists: GR-159897 Ibodutant Nepadutant Saredutant NK3 Agonists: Neurokinin B Senktide Antagonists:...
Word Count : 3270
Last Update: 2024-02-13T05:48:14Z
Vestipitant Vofopitant NK2 Agonists: Neurokinin A Antagonists: GR-159897 Ibodutant Nepadutant Saredutant NK3 Agonists: Neurokinin B Senktide Antagonists:...
Word Count : 2873
Last Update: 2023-01-26T02:47:57Z
Vestipitant Vofopitant NK2 Agonists: Neurokinin A Antagonists: GR-159897 Ibodutant Nepadutant Saredutant NK3 Agonists: Neurokinin B Senktide Antagonists:...
Word Count : 983
Last Update: 2024-03-09T23:37:26Z
Vestipitant Vofopitant NK2 Agonists: Neurokinin A Antagonists: GR-159897 Ibodutant Nepadutant Saredutant NK3 Agonists: Neurokinin B Senktide Antagonists:...
Word Count : 955
Last Update: 2024-01-07T22:18:04Z
Vestipitant Vofopitant NK2 Agonists: Neurokinin A Antagonists: GR-159897 Ibodutant Nepadutant Saredutant NK3 Agonists: Neurokinin B Senktide Antagonists:...
Word Count : 294
Last Update: 2022-04-23T10:11:01Z
Vestipitant Vofopitant NK2 Agonists: Neurokinin A Antagonists: GR-159897 Ibodutant Nepadutant Saredutant NK3 Agonists: Neurokinin B Senktide Antagonists:...
Word Count : 183
Last Update: 2023-04-03T09:36:33Z
Vestipitant Vofopitant NK2 Agonists: Neurokinin A Antagonists: GR-159897 Ibodutant Nepadutant Saredutant NK3 Agonists: Neurokinin B Senktide Antagonists:...
Word Count : 186
Last Update: 2023-12-03T06:47:57Z
Vestipitant Vofopitant NK2 Agonists: Neurokinin A Antagonists: GR-159897 Ibodutant Nepadutant Saredutant NK3 Agonists: Neurokinin B Senktide Antagonists:...
Word Count : 164
Last Update: 2022-09-06T19:23:09Z
Vestipitant Vofopitant NK2 Agonists: Neurokinin A Antagonists: GR-159897 Ibodutant Nepadutant Saredutant NK3 Agonists: Neurokinin B Senktide Antagonists:...
Word Count : 226
Last Update: 2023-12-22T10:42:13Z
Vestipitant Vofopitant NK2 Agonists: Neurokinin A Antagonists: GR-159897 Ibodutant Nepadutant Saredutant NK3 Agonists: Neurokinin B Senktide Antagonists:...
Word Count : 371
Last Update: 2024-03-14T07:12:16Z
Vestipitant Vofopitant NK2 Agonists: Neurokinin A Antagonists: GR-159897 Ibodutant Nepadutant Saredutant NK3 Agonists: Neurokinin B Senktide Antagonists:...
Word Count : 868
Last Update: 2024-03-09T23:36:03Z
agonist, EC50 3.7nM, 7-amino acid polypeptide chain. CAS# 137593-52-3 Ibodutant - failed its Phase 3 trial for IBS treatment in 2015, and abandoned by...
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