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Neurokinin A information


TAC1 tachykinin, precursor 1
Solution structure of the tachykinin peptide Neurokinin A in the presence of micelles.[1]
Identifiers
SymbolTAC1
Alt. symbolsTAC2, NKNA
NCBI gene6863
HGNC11517
OMIM162320
RefSeqNM_013998
UniProtP20366
Other data
LocusChr. 7 q21-q22
Search for
StructuresSwiss-model
DomainsInterPro
Neurokinin A
Identifiers
CAS Number
  • 86933-74-6 checkY
3D model (JSmol)
  • Interactive image
ChemSpider
  • 4470818 ☒N
IUPHAR/BPS
  • 2089
MeSH Neurokinin+A
PubChem CID
  • 55582
UNII
  • 94168F9W1D checkY
InChI
  • InChI=1S/C50H80N14O14S/c1-26(2)18-34(45(73)58-32(42(53)70)15-17-79-6)57-38(67)23-55-49(77)40(27(3)4)63-47(75)35(19-29-12-8-7-9-13-29)60-48(76)37(24-65)62-46(74)36(21-39(68)69)61-50(78)41(28(5)66)64-44(72)33(14-10-11-16-51)59-43(71)31(52)20-30-22-54-25-56-30/h7-9,12-13,22,25-28,31-37,40-41,65-66H,10-11,14-21,23-24,51-52H2,1-6H3,(H2,53,70)(H,54,56)(H,55,77)(H,57,67)(H,58,73)(H,59,71)(H,60,76)(H,61,78)(H,62,74)(H,63,75)(H,64,72)(H,68,69)/t28-,31+,32+,33+,34+,35+,36+,37+,40+,41+/m1/s1 ☒N
    Key: HEAUFJZALFKPBA-JPQUDPSNSA-N ☒N
  • InChI=1/C50H80N14O14S/c1-26(2)18-34(45(73)58-32(42(53)70)15-17-79-6)57-38(67)23-55-49(77)40(27(3)4)63-47(75)35(19-29-12-8-7-9-13-29)60-48(76)37(24-65)62-46(74)36(21-39(68)69)61-50(78)41(28(5)66)64-44(72)33(14-10-11-16-51)59-43(71)31(52)20-30-22-54-25-56-30/h7-9,12-13,22,25-28,31-37,40-41,65-66H,10-11,14-21,23-24,51-52H2,1-6H3,(H2,53,70)(H,54,56)(H,55,77)(H,57,67)(H,58,73)(H,59,71)(H,60,76)(H,61,78)(H,62,74)(H,63,75)(H,64,72)(H,68,69)/t28-,31+,32+,33+,34+,35+,36+,37+,40+,41+/m1/s1
    Key: HEAUFJZALFKPBA-JPQUDPSNBV
SMILES
  • C[C@H]([C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc2cnc[nH]2)N)O
Properties
Chemical formula
 C50H80N14O14S
Molar mass 1133.32
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
☒N verify (what is checkY☒N ?)
Infobox references

Neurokinin A (NKA), formerly known as Substance K, is a neurologically active peptide translated from the pre-protachykinin gene.[2] Neurokinin A has many excitatory effects on mammalian nervous systems and is also influential on the mammalian inflammatory and pain responses.[3]

  1. ^ PDB: 1N6T​; Chandrashekar IR, Cowsik SM (December 2003). "Three-dimensional structure of the mammalian tachykinin peptide neurokinin A bound to lipid micelles". Biophys. J. 85 (6): 4002–11. Bibcode:2003BpJ....85.4002C. doi:10.1016/S0006-3495(03)74814-0. PMC 1303701. PMID 14645089.
  2. ^ Cite error: The named reference n4 was invoked but never defined (see the help page).
  3. ^ Cite error: The named reference n23 was invoked but never defined (see the help page).

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Neurokinin A

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Tachykinin receptor

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Neurokinin 1 (NK1) antagonists (-pitants) are a novel class of medications that possesses unique antidepressant, anxiolytic, and antiemetic properties...

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Neurokinin B

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Neurokinin B (NKB) belongs in the family of tachykinin peptides. Neurokinin B is implicated in a variety of human functions and pathways such as the secretion...

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Substance P

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neuropeptides. It acts as a neurotransmitter and a neuromodulator. Substance P and the closely related neurokinin A (NKA) are produced from a polyprotein precursor...

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Tachykinin receptor 1

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tachykinin receptor 1 (TACR1) also known as neurokinin 1 receptor (NK1R) or substance P receptor (SPR) is a G protein coupled receptor found in the central...

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Tachykinin peptides

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respectively. TAC1 encodes neurokinin A (formerly known as substance K), neuropeptide K (which has also been called neurokinin K), neuropeptide gamma, and...

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Maropitant

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Maropitant (INN; brand name: Cerenia, used as maropitant citrate (USAN), is a neurokinin-1 (NK1) receptor antagonist developed by Zoetis specifically for the...

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Neuropeptide K

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(also known as neurokinin K), is a protein encoded by the TAC1 gene. It is an elongated derivative of the N-terminus of neurokinin A as the final post-translational...

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Aprepitant

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such use has not been well studied. Aprepitant belongs to the class of neurokinin-1 receptor antagonists medications. It works by blocking substance P from...

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Fezolinetant

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a medication used for the treatment of hot flashes (vasomotor symptoms) due to menopause. It is a small-molecule, orally active, selective neurokinin-3...

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Tachykinin receptor 3

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This gene encodes the receptor for the tachykinin neurokinin 3, also referred to as neurokinin B. A number of selective ligands are available for NK3...

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Puberty

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also be caused by genetics. A study discovered that a mutation in genes encoding both neurokinin B as well as the neurokinin B receptor can alter the timing...

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Elinzanetant

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names BAY-3427080 GSK-1144814, NT-814) is an orally active small-molecule neurokinin/tachykinin NK1 receptor and NK3 receptor antagonist which is under development...

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TAC1

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both substance P and neurokinin A. Neurokinin A can also be further modified to produce neuropeptide K (also known as neurokinin K) and neuropeptide gamma...

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Peptide

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Cathelicidin family Defensin family Substance P Kassinin Neurokinin A Eledoisin Neurokinin B VIP (Vasoactive Intestinal Peptide; PHM27) PACAP Pituitary...

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Tradipitant

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or LY686017) is an experimental drug that is a neurokinin 1 antagonist. It works by blocking substance P, a small signaling molecule. Originally, this compound...

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Pavinetant

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MLE-4901, AZD-4901, AZ-12472520, AZD-2624), is a small-molecule, orally active, selective neurokinin-3 (NK3) receptor antagonist which was under development...

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Rostral ventromedial medulla

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to noxious heat stimuli but not mechanical stimuli. Pretreatment with a neurokinin 1 (NK1) antagonist prevented the antinociception induced by SP injection...

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KNDy neuron

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Kisspeptin, neurokinin B, and dynorphin (KNDy) neurons are neurons in the hypothalamus of the brain that are central to the hormonal control of reproduction...

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Vofopitant

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Michelgård A, Wahlstedt K, Ahs F, Zancan S, et al. (July 2005). "Cerebral blood flow changes after treatment of social phobia with the neurokinin-1 antagonist...

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NKA

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"National Karate Association" of Canada New Kosovo Alliance, a political party Neurokinin A, a neurologically active peptide that seems to be involved in...

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Drug

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A drug is any chemical substance that when consumed causes a change in an organism's physiology, including its psychology, if applicable.[vague] Drugs...

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Vomiting

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; Chebolu Seetha; Ramirez Juan; Darmani Nissar A (2009). "Ablation of Least Shrew Central Neurokinin NK1 Receptors Reduces GR73632-Induced Vomiting"...

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Tachykinin receptor 2

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receptor for the tachykinin neuropeptide substance K, also referred to as neurokinin A. Several selective ligands for NK2 are now available, and although most...

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Preprotachykinin

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PPT-I, or PPT-A), which produces substance P and neurokinin A (also called "substance K"), and the derived neuropeptide K and neurokinin gamma. preprotachykinin-2...

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TAC3

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Tachykinin-3 is a protein that in humans is encoded by the TAC3 gene. Neurokinin B Tachykinin receptor 3 GRCh38: Ensembl release 89: ENSG00000166863 –...

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Nausea

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mediated by dopamine (D2) receptors, serotonin (5HT3) receptors, and neurokinin receptors (NK1). Vestibular system: This system is activated by disturbances...

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