Saredutant information

Saredutant
Clinical data
ATC code	none;
Identifiers
	IUPAC name N-[(2S)-4-(4-acetamido-4-phenylpiperidin-1-yl)- 2-(3,4-dichlorophenyl)butyl]-N-methylbenzamide;
CAS Number	142001-63-6 ;
PubChem CID	104974;
IUPHAR/BPS	2111;
ChemSpider	94726 ;
UNII	720U2QK8I5;
ChEMBL	ChEMBL308148 ;
CompTox Dashboard (EPA)	DTXSID00161923 ;
ECHA InfoCard	100.111.408
Chemical and physical data
Formula	C31H35Cl2N3O2
Molar mass	552.54 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES Clc1ccc(cc1Cl)[C@H](CCN3CCC(c2ccccc2)(NC(=O)C)CC3)CN(C(=O)c4ccccc4)C;
	InChI InChI=1S/C31H35Cl2N3O2/c1-23(37)34-31(27-11-7-4-8-12-27)16-19-36(20-17-31)18-15-26(25-13-14-28(32)29(33)21-25)22-35(2)30(38)24-9-5-3-6-10-24/h3-14,21,26H,15-20,22H2,1-2H3,(H,34,37)/t26-/m1/s1 ; Key:PGKXDIMONUAMFR-AREMUKBSSA-N ;
	(what is this?) (verify)

Saredutant (SR-48,968) is a drug that acts as a NK₂ receptor antagonist.^[1] It was under development by Sanofi-Aventis as a novel antidepressant and anxiolytic and made it to phase III clinical trials. However, in May 2009, Sanofi-Aventis published its quarterly results and announced the cessation of 14 research/development projects, among which was saredutant for the treatment of major depressive disorder.^[2]

^ Hopkins CR (October 2010). "ACS chemical neuroscience molecule spotlight on Saredutant". ACS Chemical Neuroscience. 1 (10): 653–4. doi:10.1021/cn100061r. PMC 3368631. PMID 22776916.
^ "Letter to the stockholders of Sanofi-Aventis" (PDF). May 2009. Archived from the original (PDF) on 21 December 2010.

[pmid22776916-1] Hopkins CR (October 2010). "ACS chemical neuroscience molecule spotlight on Saredutant". ACS Chemical Neuroscience. 1 (10): 653–4. doi:10.1021/cn100061r. PMC 3368631. PMID 22776916.

[2] "Letter to the stockholders of Sanofi-Aventis" (PDF). May 2009. Archived from the original (PDF) on 21 December 2010.

Saredutant information

and 27 Related for: Saredutant information

Saredutant

Maropitant

Substance P

Fezolinetant

Fosaprepitant

Aprepitant

Tachykinin peptides

Casopitant

Tradipitant

Pavinetant

Elinzanetant

Vofopitant

Neurokinin B

Tachykinin receptor 1

Rolapitant

Netupitant

Tachykinin receptor

Ibodutant

Neurokinin A

NK1 receptor antagonist

Osanetant

Tachykinin receptor 2

Orvepitant

Serlopitant

Vestipitant

Befetupitant

Lanepitant

Clinical data

ATC code	none
Identifiers
IUPAC name N-[(2S)-4-(4-acetamido-4-phenylpiperidin-1-yl)- 2-(3,4-dichlorophenyl)butyl]-N-methylbenzamide
CAS Number	142001-63-6^N
PubChem CID	104974
IUPHAR/BPS	2111
ChemSpider	94726^Y
UNII	720U2QK8I5
ChEMBL	ChEMBL308148^Y
CompTox Dashboard (EPA)	DTXSID00161923
ECHA InfoCard	100.111.408
Chemical and physical data
Formula	C₃₁H₃₅Cl₂N₃O₂
Molar mass	552.54 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES Clc1ccc(cc1Cl)[C@H](CCN3CCC(c2ccccc2)(NC(=O)C)CC3)CN(C(=O)c4ccccc4)C
InChI InChI=1S/C31H35Cl2N3O2/c1-23(37)34-31(27-11-7-4-8-12-27)16-19-36(20-17-31)18-15-26(25-13-14-28(32)29(33)21-25)22-35(2)30(38)24-9-5-3-6-10-24/h3-14,21,26H,15-20,22H2,1-2H3,(H,34,37)/t26-/m1/s1^Y Key:PGKXDIMONUAMFR-AREMUKBSSA-N^Y
^NY (what is this?) (verify)