OMIM: 165095 MGI: 104749 HomoloGene: 10741 GeneCards: OSM
Gene location (Human)
Chr.
Chromosome 22 (human)[1]
Band
22q12.2
Start
30,262,829 bp[1]
End
30,266,851 bp[1]
Gene location (Mouse)
Chr.
Chromosome 11 (mouse)[2]
Band
11 A1|11 2.94 cM
Start
4,186,420 bp[2]
End
4,191,026 bp[2]
RNA expression pattern
Bgee
Human
Mouse (ortholog)
Top expressed in
bone marrow cells
monocyte
blood
appendix
gallbladder
upper lobe of left lung
abdominal wall
spleen
synovial membrane
left uterine tube
Top expressed in
morula
submandibular gland
blood
thymus
spleen
dermis
placenta
skin of abdomen
yolk sac
esophagus
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
cytokine activity
oncostatin-M receptor binding
growth factor activity
Cellular component
extracellular region
extracellular space
Biological process
oncostatin-M-mediated signaling pathway
positive regulation of peptidyl-serine phosphorylation
multicellular organism development
immune response
positive regulation of cell population proliferation
positive regulation of acute inflammatory response
regulation of growth
cell population proliferation
negative regulation of hormone secretion
positive regulation of cell division
positive regulation of MAPK cascade
negative regulation of cell population proliferation
positive regulation of transcription by RNA polymerase II
positive regulation of tyrosine phosphorylation of STAT protein
regulation of signaling receptor activity
positive regulation of peptidyl-tyrosine phosphorylation
cytokine-mediated signaling pathway
positive regulation of phosphatidylinositol 3-kinase signaling
positive regulation of inflammatory response
positive regulation of protein kinase B signaling
regulation of hematopoietic stem cell differentiation
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
5008
18413
Ensembl
ENSG00000099985
ENSMUSG00000058755
UniProt
P13725
P53347
RefSeq (mRNA)
NM_020530 NM_001319108
NM_001013365
RefSeq (protein)
NP_001306037 NP_065391
NP_001013383
Location (UCSC)
Chr 22: 30.26 – 30.27 Mb
Chr 11: 4.19 – 4.19 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Oncostatin M, also known as OSM, is a protein that in humans is encoded by the OSM gene.[5]
OSM is a pleiotropic cytokine that belongs to the interleukin 6 group of cytokines.[6] Of these cytokines it most closely resembles leukemia inhibitory factor (LIF) in both structure and function.[6] As yet poorly defined, it is proving important in liver development, haematopoeisis, inflammation and possibly CNS development. It is also associated with bone formation and destruction.[7]
OSM signals through cell surface receptors that contain the protein gp130. The type I receptor is composed of gp130 and LIFR, the type II receptor is composed of gp130 and OSMR.[8]
^ abcGRCh38: Ensembl release 89: ENSG00000099985 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000058755 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Cite error: The named reference pmid1717982 was invoked but never defined (see the help page).
^ abTanaka M, Miyajima A (2003). "Oncostatin M, a multifunctional cytokine". Rev. Physiol. Biochem. Pharmacol. Reviews of Physiology, Biochemistry and Pharmacology. 149: 39–52. doi:10.1007/s10254-003-0013-1. ISBN 978-3-540-20213-4. PMID 12811586.
^Walker EC, McGregor NE, Poulton IJ, Solano M, Pompolo S, Fernandes TJ, Constable MJ, Nicholson GC, Zhang JG, Nicola NA, Gillespie MT, Martin TJ, Sims NA (2010). "Oncostatin M promotes bone formation independently of resorption when signaling through leukemia inhibitory factor receptor in mice". J Clin Invest. 120 (2): 582–92. doi:10.1172/JCI40568. PMC 2810087. PMID 20051625.
"How to build bone: Separate bone formation from bone destruction". ScienceDaily (Press release). January 5, 2010.
^Cite error: The named reference pmid9188471 was invoked but never defined (see the help page).
OncostatinM, also known as OSM, is a protein that in humans is encoded by the OSM gene. OSM is a pleiotropic cytokine that belongs to the interleukin...
Oncostatin-M specific receptor subunit beta also known as the OncostatinM receptor (OSMR) , is one of the receptor proteins for oncostatinM, that in...
antibody that works by binding to the oncostatinM receptor β, thus inhibiting both interleukin 31 and oncostatinM. It is developed by Kiniksa Pharmaceuticals...
Ocular immune system Oligoclonal band Oligopeptidase Oncoantigen OncostatinMOncostatinM receptor Opportunistic infection Oprelvekin Opsonin Organ harvesting...
including leukemia inhibitory factor (LIF), ciliary neurotropic factor, oncostatinM, IL-11 and cardiotrophin-1, and is almost ubiquitously expressed in most...
leukemia inhibitory factor (LIF), ciliary neurotrophic factor (CNTF), oncostatinM (OSM), and IL-11. There are also several other proteins which have structural...
Primary cutaneous amyloidosis is a form of amyloidosis associated with oncostatinM receptor. This type of amyloidosis has been divided into the following...
cytokines only M2 produces anti-inflammatory in muscles. The myokine oncostatinM has been shown to inhibit the proliferation of breast cancer cells, IL-6...
Tofacitinib to a lesser extent also inhibits JAK1 (IC50 = 100 nM) and JAK2 (IC50 = 20 nM), which in turn blocks IFN-γ and IL-6 signalling and consequently...
et al. (2014). "Role of Interleukin-31 and OncostatinM in Itch and Neuroimmune Communication". In Carstens M, Akiyama T (eds.). Itch: Mechanisms and Treatment...
M) concentrations that usually vary by less than one order of magnitude. In contrast, some cytokines (such as IL-6) circulate in picomolar (10-12 M)...
IL-31 sends signals through a receptor complex made of IL-31RA and oncostatinM receptor β (OSMRβ) expressed in immune and epithelial cells. These signals...
Chauhan D, Kharbanda SM, Ogata A, Urashima M, Frank D, Malik N, Kufe DW, Anderson KC (December 1995). "OncostatinM induces association of Grb2 with Janus...
production (erythropoiesis) in the bone marrow. Low levels of EPO (around 10 mU/mL) are constantly secreted in sufficient quantities to compensate for normal...
in the public domain. Chimalakonda A, Burke J, Cheng L, Catlett I, Tagen M, Zhao Q, et al. (October 2021). "Selectivity Profile of the Tyrosine Kinase...
Retrieved 23 February 2017. Gonzales AJ, Bowman JW, Fici GJ, Zhang M, Mann DW, Mitton-Fry M (August 2014). "Oclacitinib (Apoquel) is a novel Janus kinase inhibitor...
to a large family of cytokines, including IL-6, IL-11, IL-27, IL-31, oncostatinM (OSM), ciliary neurotrophic factor, cardiotrophin 1, cardiotrophin-like...
Schellack C, Karaghiosoff M, Kreibich R, Weisz E, Artwohl M, Kleine OC, Muller M, Baumgartner-Parzer S, Ghysdael J, Freissmuth M, Sexl V (2004). "TYK2 is...
subtype, IFNh in mandarin fish. Razaghi A, Brusselaers N, Björnstedt M, Durand-Dubief M (September 2021). "Copy number alteration of the interferon gene cluster...
Rheumatism. 60 (7): 1895–1905. doi:10.1002/art.24567. PMID 19565475. Herper M (2 March 2011). "Why Pfizer's Biggest Experimental Drug Got A Name Change"...
M005626200. PMID 11022036. Nakayama K, Hara T, Hibi M, Hirano T, Miyajima A (August 1999). "A novel oncostatinM-inducible gene OIG37 forms a gene family with...
Global Information
