P21 information

CDKN1A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1AXC, 2ZVV, 2ZVW, 4RJF, 5E0U
Identifiers
Aliases	CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1, cyclin-dependent kinase inhibitor 1A, cyclin dependent kinase inhibitor 1A
External IDs	OMIM: 116899 MGI: 104556 HomoloGene: 333 GeneCards: CDKN1A
Gene location (Human)
Chr.	Chromosome 6 (human)
End	36,687,339 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	29,319,701 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; gastric mucosa; ; vena cava; ; left uterine tube; ; ascending aorta; ; saphenous vein; ; popliteal artery; ; mucosa of urinary bladder; ; skin of abdomen; ; gallbladder;
	Top expressed in
	calvaria; ; molar; ; pyloric antrum; ; lip; ; esophagus; ; hair follicle; ; epithelium of stomach; ; condyle; ; sciatic nerve; ; left colon;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	metal ion binding; protein binding; cyclin-dependent protein serine/threonine kinase inhibitor activity; ubiquitin protein ligase binding; cyclin binding; cyclin-dependent protein kinase activating kinase activity; cyclin-dependent protein serine/threonine kinase activity; protein kinase inhibitor activity; protein kinase binding; protein-containing complex binding;
Cellular component	cytoplasm; cytosol; cyclin-dependent protein kinase holoenzyme complex; PCNA-p21 complex; perinuclear region of cytoplasm; nucleus; nucleoplasm; nucleolus; nuclear body; protein-containing complex;
Biological process	cellular response to extracellular stimulus; signal transduction by p53 class mediator; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; cellular response to heat; regulation of cyclin-dependent protein serine/threonine kinase activity; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; positive regulation of cell death; response to organic cyclic compound; negative regulation of cyclin-dependent protein serine/threonine kinase activity; stress-induced premature senescence; positive regulation of fibroblast proliferation; replicative senescence; response to hyperoxia; response to corticosterone; cellular response to amino acid starvation; positive regulation of programmed cell death; negative regulation of apoptotic process; response to glucocorticoid; response to arsenic-containing substance; regulation of DNA biosynthetic process; response to organic substance; negative regulation of gene expression; cellular response to DNA damage stimulus; negative regulation of G1/S transition of mitotic cell cycle; regulation of cell cycle; intrinsic apoptotic signaling pathway; cellular senescence; positive regulation of reactive oxygen species metabolic process; cellular response to UV-B; G2/M transition of mitotic cell cycle; positive regulation of B cell proliferation; negative regulation of cell growth; response to organonitrogen compound; animal organ regeneration; regulation of mitotic cell cycle; intestinal epithelial cell maturation; cellular response to ionizing radiation; cell cycle; Ras protein signal transduction; negative regulation of phosphorylation; response to toxic substance; response to UV; response to X-ray; negative regulation of cell population proliferation; protein stabilization; positive regulation of cyclin-dependent protein kinase activity; regulation of transcription by RNA polymerase II; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; positive regulation of protein kinase activity; cellular response to gamma radiation; negative regulation of cyclin-dependent protein kinase activity; transcription initiation from RNA polymerase II promoter; G1/S transition of mitotic cell cycle; cytokine-mediated signaling pathway; negative regulation of vascular associated smooth muscle cell proliferation;
	Sources:Amigo / QuickGO
Orthologs
	1026
	12575
	ENSG00000124762
	ENSMUSG00000023067
	P38936
	P39689
	NM_078467; NM_000389; NM_001220777; NM_001220778; NM_001291549
	NM_001111099; NM_007669
NP_000380; NP_001207706; NP_001207707; NP_001278478; NP_510867;
	NP_001361438; NP_001361439; NP_001361440; NP_001361441; NP_001361442
	NP_001104569; NP_031695
	Wikidata
View/Edit Human	View/Edit Mouse

p21^Cip1 (alternatively p21^Waf1), also known as cyclin-dependent kinase inhibitor 1 or CDK-interacting protein 1, is a cyclin-dependent kinase inhibitor (CKI) that is capable of inhibiting all cyclin/CDK complexes,^[5] though is primarily associated with inhibition of CDK2.^[6]^[7] p21 represents a major target of p53 activity and thus is associated with linking DNA damage to cell cycle arrest.^[8]^[9]^[10] This protein is encoded by the CDKN1A gene located on chromosome 6 (6p21.2) in humans.^[11]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000124762 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000023067 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Xiong Y, Hannon GJ, Zhang H, Casso D, Kobayashi R, Beach D (1993). "p21 is a universal inhibitor of cyclin kinases". Nature. 366 (6456): 701–4. Bibcode:1993Natur.366..701X. doi:10.1038/366701a0. PMID 8259214. S2CID 4362507.
^ Abbas, Tarek; Dutta, Anindya (2009). "p21 in cancer: intricate networks and multiple activities". Nature Reviews Cancer. 9 (6): 400–414. doi:10.1038/nrc2657. PMC 2722839. PMID 19440234.
^ Harper JW, Adami GR, Wei N, Keyomarsi K, Elledge SJ (November 1993). "The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases". Cell. 75 (4): 805–16. doi:10.1016/0092-8674(93)90499-G. PMID 8242751.
^ el-Deiry WS, Tokino T, Velculescu VE, Levy DB, Parsons R, Trent JM, Lin D, Mercer WE, Kinzler KW, Vogelstein B (November 1993). "WAF1, a potential mediator of p53 tumor suppression". Cell. 75 (4): 817–25. doi:10.1016/0092-8674(93)90500-P. PMID 8242752.
^ Bunz F, et al. (1998). "Requirement for p53 and p21 to sustain G2 arrest after DNA damage". Science. 282 (5393): 1497–1501. doi:10.1126/science.282.5393.1497. PMID 9822382.
^ Waldman, Todd, Kenneth W. Kinzler, and Bert Vogelstein. "p21 is necessary for the p53-mediated G1 arrest in human cancer cells." Cancer research 55.22 (1995): 5187-5190.
^ "Entrez Gene: CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000124762 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000023067 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8259214-5] Xiong Y, Hannon GJ, Zhang H, Casso D, Kobayashi R, Beach D (1993). "p21 is a universal inhibitor of cyclin kinases". Nature. 366 (6456): 701–4. Bibcode:1993Natur.366..701X. doi:10.1038/366701a0. PMID 8259214. S2CID 4362507.

[Abbas_Dutta_2009_pp._400–414-6] Abbas, Tarek; Dutta, Anindya (2009). "p21 in cancer: intricate networks and multiple activities". Nature Reviews Cancer. 9 (6): 400–414. doi:10.1038/nrc2657. PMC 2722839. PMID 19440234.

[pmid8242751-7] Harper JW, Adami GR, Wei N, Keyomarsi K, Elledge SJ (November 1993). "The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases". Cell. 75 (4): 805–16. doi:10.1016/0092-8674(93)90499-G. PMID 8242751.

[pmid8242752-8] -Deiry WS, Tokino T, Velculescu VE, Levy DB, Parsons R, Trent JM, Lin D, Mercer WE, Kinzler KW, Vogelstein B (November 1993). "WAF1, a potential mediator of p53 tumor suppression". Cell. 75 (4): 817–25. doi:10.1016/0092-8674(93)90500-P. PMID 8242752.

[Bunz-9] Bunz F, et al. (1998). "Requirement for p53 and p21 to sustain G2 arrest after DNA damage". Science. 282 (5393): 1497–1501. doi:10.1126/science.282.5393.1497. PMID 9822382.

[Waldman-10] Waldman, Todd, Kenneth W. Kinzler, and Bert Vogelstein. "p21 is necessary for the p53-mediated G1 arrest in human cancer cells." Cancer research 55.22 (1995): 5187-5190.

[entrez-11] "Entrez Gene: CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)".

P21 information

and 22 Related for: P21 information

P21

Ras GTPase

21st century skills

Cyprien Katsaris

HRAS

Elkinstantonite

PAK1

Narendra Modi

P21 holin family

Ras p21 protein activator 2

KRAS

Phosphophyllite

Uranate

Monoclinic crystal system

SS Richard Montgomery

Geography Markup Language

Patrol boat

Shaitan

Peugeot 208

Multiple myeloma

2015 United Nations Climate Change Conference

Metabolic age