Leukemia inhibitory factor receptor information

LIFR
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3E0G
Identifiers
Aliases	LIFR, CD118, LIF-R, SJS2, STWS, SWS, leukemia inhibitory factor receptor alpha, LIF receptor alpha, LIF receptor subunit alpha
External IDs	OMIM: 151443 MGI: 96788 HomoloGene: 1735 GeneCards: LIFR
Gene location (Human)
Chr.	Chromosome 5 (human)
End	38,608,354 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	7,226,970 bp
RNA expression pattern
	Top expressed in
	internal globus pallidus; ; external globus pallidus; ; tibia; ; Achilles tendon; ; subthalamic nucleus; ; pons; ; cardia; ; lower lobe of lung; ; superficial temporal artery; ; inferior ganglion of vagus nerve;
	Top expressed in
	body of femur; ; sternocleidomastoid muscle; ; parotid gland; ; facial motor nucleus; ; triceps brachii muscle; ; temporal muscle; ; trigeminal ganglion; ; seminal vesicula; ; vastus lateralis muscle; ; pontine nuclei;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	ciliary neurotrophic factor receptor activity; growth factor binding; oncostatin-M receptor activity; protein binding; cytokine receptor activity; ciliary neurotrophic factor receptor binding; leukemia inhibitory factor receptor activity; cytokine binding;
Cellular component	integral component of membrane; membrane; plasma membrane; receptor complex; integral component of plasma membrane; extracellular region; extracellular exosome; extracellular space; external side of plasma membrane;
Biological process	response to cytokine; leukemia inhibitory factor signaling pathway; oncostatin-M-mediated signaling pathway; cytokine-mediated signaling pathway; ciliary neurotrophic factor-mediated signaling pathway; cell surface receptor signaling pathway; positive regulation of cell population proliferation; regulation of cytokine-mediated signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	3977
	16880
	ENSG00000113594
	ENSMUSG00000054263
	P42702
	P42703
	NM_001127671; NM_002310; NM_001364297; NM_001364298
	NM_001113386; NM_013584; NM_001358593
	NP_001121143; NP_002301; NP_001351226; NP_001351227
	NP_001106857; NP_038612; NP_001345522
	Wikidata
View/Edit Human	View/Edit Mouse

LIFR also known as CD118 (Cluster of Differentiation 118), is a subunit of a receptor for leukemia inhibitory factor.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000113594 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000054263 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000113594 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000054263 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

Leukemia inhibitory factor receptor information

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Leukemia inhibitory factor receptor

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Type I cytokine receptor

Oncostatin M

Oncostatin M receptor

Glycoprotein 130

Epidermal growth factor receptor

Fibroblast growth factor receptor

Cytokine receptor

Nerve growth factor

Fibroblast growth factor receptor 1

Vascular endothelial growth factor

Growth factor

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Neurotrophic factors

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Tissue factor