positive regulation of transcription, DNA-templated
response to mechanical stimulus
negative regulation of protein-containing complex assembly
negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification
cellular response to parathyroid hormone stimulus
ossification
negative regulation of ossification
negative regulation of canonical Wnt signaling pathway
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
50964
74499
Ensembl
ENSG00000167941
ENSMUSG00000001494
UniProt
Q9BQB4
Q99P68
RefSeq (mRNA)
NM_025237
NM_024449
RefSeq (protein)
NP_079513
NP_077769
Location (UCSC)
Chr 17: 43.75 – 43.76 Mb
Chr 11: 101.85 – 101.86 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Sclerostin
Identifiers
Symbol
Sclerostin
Pfam
PF05463
InterPro
IPR008835
Available protein structures:
Pfam
structures / ECOD
PDB
RCSB PDB; PDBe; PDBj
PDBsum
structure summary
Sclerostin is a protein that in humans is encoded by the SOST gene.[5] It is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Sclerostin is produced primarily by the osteocyte but is also expressed in other tissues,[6] and has anti-anabolic effects on bone formation.[7]
^ abcGRCh38: Ensembl release 89: ENSG00000167941 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000001494 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Brunkow ME, Gardner JC, Van Ness J, Paeper BW, Kovacevich BR, Proll S, et al. (March 2001). "Bone dysplasia sclerosteosis results from loss of the SOST gene product, a novel cystine knot-containing protein". American Journal of Human Genetics. 68 (3): 577–89. doi:10.1086/318811. PMC 1274471. PMID 11179006.
^Hernandez P, Whitty C, John Wardale R, Henson FM (April 2014). "New insights into the location and form of sclerostin". Biochemical and Biophysical Research Communications. 446 (4): 1108–13. doi:10.1016/j.bbrc.2014.03.079. PMID 24667598.
Sclerostin is a protein that in humans is encoded by the SOST gene. It is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and...
synthesize sclerostin, a secreted protein that inhibits bone formation by binding to LRP5/LRP6 coreceptors and blunting Wnt signaling. Sclerostin, the product...
cardiovascular disease. It is a humanized monoclonal antibody that targets sclerostin. Research shows the drug increases bone formation and decreases bone resorption...
is caused by mutations in the SOST gene that encodes the sclerostin protein. The sclerostin protein is necessary in inhibiting the Wnt signaling pathway...
(sold under the brand name Evenity) is a monoclonal antibody against sclerostin. Romosozumab is usually reserved for patients with very high fracture...
M, Andersen T, Gossiel F, et al. (August 2011). "Levels of serotonin, sclerostin, bone turnover markers as well as bone density and microarchitecture in...
Sclerostin domain-containing protein 1 is a protein that in humans is encoded by the SOSTDC1 gene. This gene is a member of the sclerostin family and encodes...
The gene involved is SOST, and by extension the protein involved is sclerostin. There have been attempts to relieve a patient suffering from van Buchem...
additional mechanism is secretion by osteocytes, buried in the matrix, of sclerostin, a protein that inhibits a pathway that maintains osteoblast activity...
Samiei M, Janjić K, Cvikl B, Moritz A, Agis H (2019-01-30). "The role of sclerostin and dickkopf-1 in oral tissues - A review from the perspective of the...
multiple-dose randomized studies of blosozumab, a monoclonal antibody against sclerostin, in healthy postmenopausal women". Journal of Bone and Mineral Research...
Hautes-Pyrénées, a commune in France SOST, a gene that encodes the protein sclerostin Söst, Germany Special Operations Science and Technology ammunition, see...
osteocytes. There are promising osteoporosis clinical trials targeting sclerostin, an osteocyte-specific protein which inhibits Wnt signaling by binding...
regulated by extracellular proteins in the Dickkopf (Dkk) family (like DKK1), sclerostin, R-spondins and members of the cysteine-knot-type protein family. Loss-of-function...
growth factor (IGF), endothelin-1, bone morphogenetic proteins (BMPs), sclerostin and Wnt proteins that act on local bone to increase osteoblast proliferation...
R, Cloutier AM, Louis L, van Vliet M, Suva LJ, et al. (April 2013). "Sclerostin antibody inhibits skeletal deterioration due to reduced mechanical loading"...
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