"IL-31" redirects here. For the road, see Illinois Route 31.
IL31
Identifiers
Aliases
IL31, IL-31, interleukin 31
External IDs
OMIM: 609509 HomoloGene: 88541 GeneCards: IL31
Gene location (Human)
Chr.
Chromosome 12 (human)[1]
Band
12q24.31
Start
122,172,029 bp[1]
End
122,174,221 bp[1]
RNA expression pattern
Bgee
Human
Mouse (ortholog)
Top expressed in
gastric mucosa
human musculoskeletal system
gastrocnemius muscle
islet of Langerhans
n/a
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
cytokine activity
cytokine receptor binding
Cellular component
extracellular region
extracellular space
Biological process
immune system process
regulation of signaling receptor activity
cytokine-mediated signaling pathway
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
386653
n/a
Ensembl
ENSG00000204671
n/a
UniProt
Q6EBC2
n/a
RefSeq (mRNA)
NM_001014336
n/a
RefSeq (protein)
NP_001014358
n/a
Location (UCSC)
Chr 12: 122.17 – 122.17 Mb
n/a
PubMed search
[2]
n/a
Wikidata
View/Edit Human
Interleukin-31 (IL-31) is a protein that in humans is encoded by the IL31 gene that resides on chromosome 12.[3][4][5] IL-31 is an inflammatory cytokine that helps trigger cell-mediated immunity against pathogens. It has also been identified as a major player in a number of chronic inflammatory diseases, including atopic dermatitis.[5][6]
IL-31 is produced by a variety of cells, namely type 2 helper (TH2) T-cells.[5] IL-31 sends signals through a receptor complex made of IL-31RA and oncostatin M receptor β (OSMRβ) expressed in immune and epithelial cells.[7] These signals activate three pathways: ERK1/2 MAP kinase, PI3K/AKT, and JAK1/2 signaling pathways.[5][6]
^ abcGRCh38: Ensembl release 89: ENSG00000204671 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Cite error: The named reference entrez was invoked but never defined (see the help page).
^Cite error: The named reference Dillon_2004 was invoked but never defined (see the help page).
^ abcdCite error: The named reference Cornelissen_2012 was invoked but never defined (see the help page).
^ abCite error: The named reference Zhang_2008 was invoked but never defined (see the help page).
^Cite error: The named reference Rabenhorst_2014 was invoked but never defined (see the help page).
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